FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200194241> ?p ?o ?g. }

• W4200194241 abstract "Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in relation to the development and progression of cancers in which the isoform A2 is mainly expressed. However, an increasing number of studies report that the isoform A1, which is ubiquitously expressed in normal cells, exhibits novel molecular features that reveal its new relationships between cellular functions and organ homeostasis. At a first glance, eIF5A can be regarded, among other things, as a factor implicated in the initiation of translation. Nevertheless, at least three specificities: (1) its extreme conservation between species, including plants, throughout evolution, (2) its very special and unique post-translational modification through the activating-hypusination process, and finally (3) its close relationship with the polyamine pathway, suggest that the role of eIF5A in living beings remains to be uncovered. In fact, and beyond its involvement in facilitating the translation of proteins containing polyproline residues, eIF5A is implicated in various physiological processes including ischemic tolerance, metabolic adaptation, aging, development, and immune cell differentiation. These newly discovered physiological properties open up huge opportunities in the clinic for pathologies such as, for example, the ones in which the oxygen supply is disrupted. In this latter case, organ transplantation, myocardial infarction or stroke are concerned, and the current literature defines eIF5A as a new drug target with a high level of potential benefit for patients with these diseases or injuries. Moreover, the recent use of genomic and transcriptomic association along with metadata studies also revealed the implication of eIF5A in genetic diseases. Thus, this review provides an overview of eIF5A from its molecular mechanism of action to its physiological roles and the clinical possibilities that have been recently reported in the literature." @default.
• W4200194241 created "2021-12-31" @default.
• W4200194241 creator A5006637534 @default.
• W4200194241 creator A5009107030 @default.
• W4200194241 creator A5013532042 @default.
• W4200194241 creator A5026210887 @default.
• W4200194241 creator A5026809269 @default.
• W4200194241 creator A5045897447 @default.
• W4200194241 creator A5082913432 @default.
• W4200194241 creator A5084820029 @default.
• W4200194241 date "2021-12-24" @default.
• W4200194241 modified "2023-10-07" @default.
• W4200194241 title "The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles" @default.
• W4200194241 cites W1506072704 @default.
• W4200194241 cites W1531987646 @default.
• W4200194241 cites W1544068656 @default.
• W4200194241 cites W1544786964 @default.
• W4200194241 cites W1604325579 @default.
• W4200194241 cites W1940370246 @default.
• W4200194241 cites W1946679440 @default.
• W4200194241 cites W1966234811 @default.
• W4200194241 cites W1967833570 @default.
• W4200194241 cites W1968202347 @default.
• W4200194241 cites W1974243304 @default.
• W4200194241 cites W1974671442 @default.
• W4200194241 cites W1976039079 @default.
• W4200194241 cites W1976954198 @default.
• W4200194241 cites W1977735671 @default.
• W4200194241 cites W1983088975 @default.
• W4200194241 cites W1983788160 @default.
• W4200194241 cites W1985288736 @default.
• W4200194241 cites W1985874026 @default.
• W4200194241 cites W1987533090 @default.
• W4200194241 cites W1987966670 @default.
• W4200194241 cites W1992021408 @default.
• W4200194241 cites W1992575040 @default.
• W4200194241 cites W1996153912 @default.
• W4200194241 cites W1998666012 @default.
• W4200194241 cites W2003784351 @default.
• W4200194241 cites W2004327549 @default.
• W4200194241 cites W2008372207 @default.
• W4200194241 cites W2011171003 @default.
• W4200194241 cites W2012221021 @default.
• W4200194241 cites W2012669126 @default.
• W4200194241 cites W2014272469 @default.
• W4200194241 cites W2014489014 @default.
• W4200194241 cites W2016244765 @default.
• W4200194241 cites W2018202198 @default.
• W4200194241 cites W2018319627 @default.
• W4200194241 cites W2018803778 @default.
• W4200194241 cites W2024323013 @default.
• W4200194241 cites W2026483801 @default.
• W4200194241 cites W2038051327 @default.
• W4200194241 cites W2038511535 @default.
• W4200194241 cites W2041395895 @default.
• W4200194241 cites W2041593752 @default.
• W4200194241 cites W2045611938 @default.
• W4200194241 cites W2048723540 @default.
• W4200194241 cites W2056026567 @default.
• W4200194241 cites W2057803077 @default.
• W4200194241 cites W2059699638 @default.
• W4200194241 cites W2066511859 @default.
• W4200194241 cites W2070306280 @default.
• W4200194241 cites W2071417493 @default.
• W4200194241 cites W2073836327 @default.
• W4200194241 cites W2079596280 @default.
• W4200194241 cites W2080480715 @default.
• W4200194241 cites W2082090012 @default.
• W4200194241 cites W2087690112 @default.
• W4200194241 cites W2094330276 @default.
• W4200194241 cites W2097821680 @default.
• W4200194241 cites W2098224012 @default.
• W4200194241 cites W2100177180 @default.
• W4200194241 cites W2113206573 @default.
• W4200194241 cites W2114915170 @default.
• W4200194241 cites W2115162201 @default.
• W4200194241 cites W2115796752 @default.
• W4200194241 cites W2118718951 @default.
• W4200194241 cites W2123975270 @default.
• W4200194241 cites W2132868628 @default.
• W4200194241 cites W2133234260 @default.
• W4200194241 cites W2134235310 @default.
• W4200194241 cites W2137441527 @default.
• W4200194241 cites W2142848145 @default.
• W4200194241 cites W2147098807 @default.
• W4200194241 cites W2150055598 @default.
• W4200194241 cites W2152803022 @default.
• W4200194241 cites W2153513788 @default.
• W4200194241 cites W2156540830 @default.
• W4200194241 cites W2158527336 @default.
• W4200194241 cites W2164134642 @default.
• W4200194241 cites W2169117131 @default.
• W4200194241 cites W2170306755 @default.
• W4200194241 cites W2185323554 @default.
• W4200194241 cites W2191096966 @default.
• W4200194241 cites W2215228456 @default.
• W4200194241 cites W2223861440 @default.
• W4200194241 cites W2277117704 @default.
• W4200194241 cites W2281124822 @default.
• W4200194241 cites W2346302216 @default.

• next