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- W4200200321 abstract "Abstract Understanding the genetic basis of environmental adaptation in natural populations is a central goal in evolutionary biology. The conditions at high elevation, particularly the low oxygen available in the ambient air, impose a significant and chronic environmental challenge to metabolically active animals with lowland ancestry. To understand the process of adaptation to these novel conditions and to assess the repeatability of evolution over short timescales, we examined the signature of selection from complete exome sequences of house mice (Mus musculus domesticus) sampled across two elevational transects in the Andes of South America. Using phylogenetic analysis, we show that house mice colonized high elevations independently in Ecuador and Bolivia. Overall, we found distinct responses to selection in each transect and largely nonoverlapping sets of candidate genes, consistent with the complex nature of traits that underlie adaptation to low oxygen availability (hypoxia) in other species. Nonetheless, we also identified a small subset of the genome that appears to be under parallel selection at the gene and SNP levels. In particular, three genes (Col22a1, Fgf14, and srGAP1) bore strong signatures of selection in both transects. Finally, we observed several patterns that were common to both transects, including an excess of derived alleles at high elevation, and a number of hypoxia-associated genes exhibiting a threshold effect, with a large allele frequency change only at the highest elevations. This threshold effect suggests that selection pressures may increase disproportionately at high elevations in mammals, consistent with observations of some high-elevation diseases in humans." @default.
- W4200200321 created "2021-12-31" @default.
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- W4200200321 date "2021-12-13" @default.
- W4200200321 modified "2023-10-16" @default.
- W4200200321 title "The genomic basis of high-elevation adaptation in wild house mice (<i>Mus musculus domesticus</i>) from South America" @default.
- W4200200321 cites W1567686877 @default.
- W4200200321 cites W1775546741 @default.
- W4200200321 cites W1817357276 @default.
- W4200200321 cites W1919257374 @default.
- W4200200321 cites W1978095252 @default.
- W4200200321 cites W1979889694 @default.
- W4200200321 cites W1981234696 @default.
- W4200200321 cites W1991301405 @default.
- W4200200321 cites W1991558095 @default.
- W4200200321 cites W1991738738 @default.
- W4200200321 cites W1997476591 @default.
- W4200200321 cites W1999623479 @default.
- W4200200321 cites W2001473063 @default.
- W4200200321 cites W2007187838 @default.
- W4200200321 cites W2010947174 @default.
- W4200200321 cites W2022336413 @default.
- W4200200321 cites W2025912597 @default.
- W4200200321 cites W2042613032 @default.
- W4200200321 cites W2043701535 @default.
- W4200200321 cites W2047366062 @default.
- W4200200321 cites W2051152628 @default.
- W4200200321 cites W2062818316 @default.
- W4200200321 cites W2067470136 @default.
- W4200200321 cites W2070561257 @default.
- W4200200321 cites W2071941077 @default.
- W4200200321 cites W2075183916 @default.
- W4200200321 cites W2078074521 @default.
- W4200200321 cites W2090312959 @default.
- W4200200321 cites W2092574926 @default.
- W4200200321 cites W2096483686 @default.
- W4200200321 cites W2098861504 @default.
- W4200200321 cites W2099085143 @default.
- W4200200321 cites W2100482242 @default.
- W4200200321 cites W2102619694 @default.
- W4200200321 cites W2103337472 @default.
- W4200200321 cites W2103604860 @default.
- W4200200321 cites W2105799757 @default.
- W4200200321 cites W2107604105 @default.
- W4200200321 cites W2108234281 @default.
- W4200200321 cites W2109099152 @default.
- W4200200321 cites W2111629801 @default.
- W4200200321 cites W2115837368 @default.
- W4200200321 cites W2118653526 @default.
- W4200200321 cites W2120437623 @default.
- W4200200321 cites W2123415055 @default.
- W4200200321 cites W2124417063 @default.
- W4200200321 cites W2129034036 @default.
- W4200200321 cites W2130234063 @default.
- W4200200321 cites W2130517250 @default.
- W4200200321 cites W2130654293 @default.
- W4200200321 cites W2132793635 @default.
- W4200200321 cites W2139752884 @default.
- W4200200321 cites W2139763955 @default.
- W4200200321 cites W2141052558 @default.
- W4200200321 cites W2142003314 @default.
- W4200200321 cites W2143622319 @default.
- W4200200321 cites W2147575903 @default.
- W4200200321 cites W2147634297 @default.
- W4200200321 cites W2147865003 @default.
- W4200200321 cites W2149716668 @default.
- W4200200321 cites W2149992227 @default.
- W4200200321 cites W2150309666 @default.
- W4200200321 cites W2150628872 @default.
- W4200200321 cites W2152613935 @default.
- W4200200321 cites W2153530045 @default.
- W4200200321 cites W2155296569 @default.
- W4200200321 cites W2156356576 @default.
- W4200200321 cites W2159583644 @default.
- W4200200321 cites W2167227133 @default.
- W4200200321 cites W2168475074 @default.
- W4200200321 cites W2168784077 @default.
- W4200200321 cites W2169380155 @default.
- W4200200321 cites W2169423961 @default.
- W4200200321 cites W2171815113 @default.
- W4200200321 cites W2172982511 @default.
- W4200200321 cites W2180834397 @default.
- W4200200321 cites W2228720667 @default.
- W4200200321 cites W2294949682 @default.
- W4200200321 cites W2318006440 @default.
- W4200200321 cites W2417483443 @default.
- W4200200321 cites W2474640767 @default.
- W4200200321 cites W2506117179 @default.
- W4200200321 cites W2512421145 @default.
- W4200200321 cites W2520945469 @default.
- W4200200321 cites W2560684108 @default.