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- W4200202345 endingPage "50" @default.
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- W4200202345 abstract "In the quest for a formidable weapon against the SARS-CoV-2 pandemic, mRNA therapeutics have stolen the spotlight. mRNA vaccines are a prime example of the benefits of mRNA approaches towards a broad array of clinical entities and druggable targets. Amongst these benefits is the rapid cycle from design to production of an mRNA product compared to their peptide counterparts, the mutability of the production line should another target be chosen, the side-stepping of safety issues posed by DNA therapeutics being permanently integrated into the transfected cell's genome and the controlled precision over the translated peptides. Furthermore, mRNA applications are versatile: apart from vaccines it can be used as a replacement therapy, even to create chimeric antigen receptor T-cells or reprogram somatic cells. Still, the sudden global demand for mRNA has highlighted the shortcomings in its industrial production as well as its formulation, efficacy and applicability. Continuous, smart mRNA manufacturing 4.0 technologies have been recently proposed to address such challenges. In this work, we examine the lab and upscaled production of mRNA therapeutics, the mRNA modifications proposed that increase its efficacy and lower its immunogenicity, the vectors available for delivery and the stability considerations concerning long-term storage." @default.
- W4200202345 created "2021-12-31" @default.
- W4200202345 creator A5011028952 @default.
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- W4200202345 creator A5071584536 @default.
- W4200202345 creator A5072794690 @default.
- W4200202345 date "2021-12-27" @default.
- W4200202345 modified "2023-10-18" @default.
- W4200202345 title "mRNA Therapeutic Modalities Design, Formulation and Manufacturing under Pharma 4.0 Principles" @default.
- W4200202345 cites W1215958058 @default.
- W4200202345 cites W1531431054 @default.
- W4200202345 cites W1614468563 @default.
- W4200202345 cites W1936936886 @default.
- W4200202345 cites W1945220000 @default.
- W4200202345 cites W1963706689 @default.
- W4200202345 cites W1970949525 @default.
- W4200202345 cites W1976684284 @default.
- W4200202345 cites W1985117052 @default.
- W4200202345 cites W1985334205 @default.
- W4200202345 cites W1988193392 @default.
- W4200202345 cites W1988620094 @default.
- W4200202345 cites W1989234766 @default.
- W4200202345 cites W1997787046 @default.
- W4200202345 cites W1998178446 @default.
- W4200202345 cites W2000136129 @default.
- W4200202345 cites W2001322125 @default.
- W4200202345 cites W2002390964 @default.
- W4200202345 cites W2004184898 @default.
- W4200202345 cites W2005453114 @default.
- W4200202345 cites W2009482334 @default.
- W4200202345 cites W2013321787 @default.
- W4200202345 cites W2015057312 @default.
- W4200202345 cites W2015178379 @default.
- W4200202345 cites W2018613110 @default.
- W4200202345 cites W2025595101 @default.
- W4200202345 cites W2026083914 @default.
- W4200202345 cites W2027131183 @default.
- W4200202345 cites W2028545827 @default.
- W4200202345 cites W2029706883 @default.
- W4200202345 cites W2037970679 @default.
- W4200202345 cites W2039357236 @default.
- W4200202345 cites W2040448004 @default.
- W4200202345 cites W2041597860 @default.
- W4200202345 cites W2042325984 @default.
- W4200202345 cites W2051758698 @default.
- W4200202345 cites W2054412308 @default.
- W4200202345 cites W2058647478 @default.
- W4200202345 cites W2061028149 @default.
- W4200202345 cites W2062299199 @default.
- W4200202345 cites W2066044406 @default.
- W4200202345 cites W2071302752 @default.
- W4200202345 cites W2075047419 @default.
- W4200202345 cites W2076304484 @default.
- W4200202345 cites W2078532145 @default.
- W4200202345 cites W2080294842 @default.
- W4200202345 cites W2082192685 @default.
- W4200202345 cites W2085637863 @default.
- W4200202345 cites W2086631864 @default.
- W4200202345 cites W2089383677 @default.
- W4200202345 cites W2097603366 @default.
- W4200202345 cites W2097861808 @default.
- W4200202345 cites W2102797150 @default.
- W4200202345 cites W2107161595 @default.
- W4200202345 cites W2113326511 @default.
- W4200202345 cites W2125708644 @default.
- W4200202345 cites W2126209532 @default.
- W4200202345 cites W2126865761 @default.
- W4200202345 cites W2129726167 @default.
- W4200202345 cites W2135221612 @default.
- W4200202345 cites W2137913086 @default.
- W4200202345 cites W2140617443 @default.
- W4200202345 cites W2144548050 @default.
- W4200202345 cites W2146445916 @default.
- W4200202345 cites W2148627082 @default.
- W4200202345 cites W2151807978 @default.
- W4200202345 cites W2157223915 @default.
- W4200202345 cites W2167338430 @default.
- W4200202345 cites W2188450487 @default.
- W4200202345 cites W2221797292 @default.
- W4200202345 cites W2246990966 @default.
- W4200202345 cites W2282836196 @default.
- W4200202345 cites W2285881370 @default.
- W4200202345 cites W2292780485 @default.
- W4200202345 cites W2300671107 @default.
- W4200202345 cites W2304189068 @default.
- W4200202345 cites W2315066459 @default.
- W4200202345 cites W2323505647 @default.
- W4200202345 cites W2339574870 @default.
- W4200202345 cites W2339898967 @default.
- W4200202345 cites W2340049980 @default.
- W4200202345 cites W2366515245 @default.
- W4200202345 cites W2375722265 @default.
- W4200202345 cites W2395331380 @default.
- W4200202345 cites W2412158473 @default.