FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200203528> ?p ?o ?g. }

• W4200203528 endingPage "91" @default.
• W4200203528 startingPage "85" @default.
• W4200203528 abstract "General design principles for recognition at noncanonical interfaces of DNA and RNA remain elusive. Triplex hybridization of bifacial peptide nucleic acids (bPNAs) with oligo-T/U DNAs and RNAs is a robust recognition platform that can be used to define structure-function relationships in synthetic triplex formation. To this end, a set of minimal (mw < 1 kD) bPNA variants was synthesized to probe the impact of amino acid secondary structural propensity, stereochemistry, and backbone cyclization on hybridization with short, unstructured T-rich DNA and U-rich RNAs. Thermodynamic parameters extracted from optical melting analyses of bPNA variant hybrids indicated that there are two bPNA backbone modifications that significantly improve hybridization: alternating (d, l) configuration in open-chain dipeptides and homochiral dipeptide cyclization to diketopiperazine. Further, binding to DNA is preferred over RNA for all bPNA variants. Thymine-uracil substitutions in DNA substrates revealed that the methyl group of thymine accounts for 71% of ΔΔGDNA-RNA for open-chain bPNAs but only 40% of ΔΔGDNA-RNA for diketopiperazine bPNA, suggesting a greater sensitivity to RNA conformation and more optimized stacking in the cyclic bPNA. Together, these data reveal pressure points for tuning triplex hybridization at the chiral centers of bPNA, backbone conformation, stacking effects at the base triple, and the nucleic acid substrate itself. A structural blueprint for enhancing bPNA targeting of both DNA and RNA substrates includes syndiotactic base presentation (as found in homochiral diketopiperazines and d, l peptides), expansion of base stacking, and further investigation of bPNA backbone preorganization." @default.
• W4200203528 created "2021-12-31" @default.
• W4200203528 creator A5000784721 @default.
• W4200203528 creator A5016411319 @default.
• W4200203528 creator A5064558120 @default.
• W4200203528 date "2021-12-27" @default.
• W4200203528 modified "2023-10-16" @default.
• W4200203528 title "Enhanced Triplex Hybridization of DNA and RNA via Syndiotactic Side Chain Presentation in Minimal bPNAs" @default.
• W4200203528 cites W1974694634 @default.
• W4200203528 cites W1980391566 @default.
• W4200203528 cites W1985775264 @default.
• W4200203528 cites W1988283896 @default.
• W4200203528 cites W1990426851 @default.
• W4200203528 cites W1993190737 @default.
• W4200203528 cites W1993239211 @default.
• W4200203528 cites W1998196358 @default.
• W4200203528 cites W2001937240 @default.
• W4200203528 cites W2016590117 @default.
• W4200203528 cites W2017483450 @default.
• W4200203528 cites W2022807913 @default.
• W4200203528 cites W2022939277 @default.
• W4200203528 cites W2023100445 @default.
• W4200203528 cites W2026313962 @default.
• W4200203528 cites W2040054282 @default.
• W4200203528 cites W2042933997 @default.
• W4200203528 cites W2048576571 @default.
• W4200203528 cites W2057992101 @default.
• W4200203528 cites W2058276221 @default.
• W4200203528 cites W2062713018 @default.
• W4200203528 cites W2070494567 @default.
• W4200203528 cites W2072645224 @default.
• W4200203528 cites W2073975963 @default.
• W4200203528 cites W2086970742 @default.
• W4200203528 cites W2112647321 @default.
• W4200203528 cites W2119002224 @default.
• W4200203528 cites W2149995572 @default.
• W4200203528 cites W2277142796 @default.
• W4200203528 cites W2282127181 @default.
• W4200203528 cites W2313986622 @default.
• W4200203528 cites W2317968851 @default.
• W4200203528 cites W2330418239 @default.
• W4200203528 cites W2345742942 @default.
• W4200203528 cites W2735992763 @default.
• W4200203528 cites W2790114481 @default.
• W4200203528 cites W2899054072 @default.
• W4200203528 cites W2899192719 @default.
• W4200203528 cites W2941035388 @default.
• W4200203528 cites W2945656597 @default.
• W4200203528 cites W2945919964 @default.
• W4200203528 cites W2947601487 @default.
• W4200203528 cites W2950751823 @default.
• W4200203528 cites W2963667696 @default.
• W4200203528 cites W2969772468 @default.
• W4200203528 cites W3033458029 @default.
• W4200203528 cites W3088613912 @default.
• W4200203528 cites W3171384196 @default.
• W4200203528 cites W3192170942 @default.
• W4200203528 cites W4245093664 @default.
• W4200203528 doi "https://doi.org/10.1021/acs.biochem.1c00693" @default.
• W4200203528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34955016" @default.
• W4200203528 hasPublicationYear "2021" @default.
• W4200203528 type Work @default.
• W4200203528 citedByCount "5" @default.
• W4200203528 countsByYear W42002035282022 @default.
• W4200203528 countsByYear W42002035282023 @default.
• W4200203528 crossrefType "journal-article" @default.
• W4200203528 hasAuthorship W4200203528A5000784721 @default.
• W4200203528 hasAuthorship W4200203528A5016411319 @default.
• W4200203528 hasAuthorship W4200203528A5064558120 @default.
• W4200203528 hasBestOaLocation W42002035282 @default.
• W4200203528 hasConcept C104317684 @default.
• W4200203528 hasConcept C178790620 @default.
• W4200203528 hasConcept C185581394 @default.
• W4200203528 hasConcept C185592680 @default.
• W4200203528 hasConcept C24107716 @default.
• W4200203528 hasConcept C2776858809 @default.
• W4200203528 hasConcept C33347731 @default.
• W4200203528 hasConcept C54871578 @default.
• W4200203528 hasConcept C552990157 @default.
• W4200203528 hasConcept C55493867 @default.
• W4200203528 hasConcept C67705224 @default.
• W4200203528 hasConcept C71240020 @default.
• W4200203528 hasConceptScore W4200203528C104317684 @default.
• W4200203528 hasConceptScore W4200203528C178790620 @default.
• W4200203528 hasConceptScore W4200203528C185581394 @default.
• W4200203528 hasConceptScore W4200203528C185592680 @default.
• W4200203528 hasConceptScore W4200203528C24107716 @default.
• W4200203528 hasConceptScore W4200203528C2776858809 @default.
• W4200203528 hasConceptScore W4200203528C33347731 @default.
• W4200203528 hasConceptScore W4200203528C54871578 @default.
• W4200203528 hasConceptScore W4200203528C552990157 @default.
• W4200203528 hasConceptScore W4200203528C55493867 @default.
• W4200203528 hasConceptScore W4200203528C67705224 @default.
• W4200203528 hasConceptScore W4200203528C71240020 @default.
• W4200203528 hasFunder F4320309374 @default.
• W4200203528 hasFunder F4320337354 @default.
• W4200203528 hasFunder F4320337367 @default.
• W4200203528 hasIssue "2" @default.

• next