FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200203791> ?p ?o ?g. }

• W4200203791 endingPage "105564" @default.
• W4200203791 startingPage "105564" @default.
• W4200203791 abstract "In 2016, H5N8 avian influenza viruses of clade 2.3.4.4b were detected at Qinghai Lake, China. Afterwards, the viruses of this clade rapidly spread to Asia, Europe, and Africa via migratory birds, and caused massive deaths in poultry and wild birds globally. In this study, four H5N8 isolates (abbreviated as 001, 002, 003, and 004) were isolated from the live poultry market in Xinjiang in 2017. Phylogenetic analysis showed that the hemagglutinin genes of the four isolates belonged to clade 2.3.4.4b, while the viral gene segments were from multiple geographic origins. For 002, the polymerase acidic gene had the highest sequence homology (99.55 %) with H5N8 virus identified from green-winged teal in Egypt in 2016, and the remaining genes exhibited the highest sequence homologies (99.18-100 %) with those of H5N8 viruses isolated from domestic duck sampled in Siberia in 2016. The polymerase basic 1 gene clustered together with H5N8 virus identified from painted stork of India in 2016, and the remaining genes had relatively close genetic relationships with H5N8 viruses identified from the duck of Siberia in 2016 and turkey in Italy in 2017. For the other three isolates, the nucleoprotein gene of 001 had the highest sequence homology (98.82 %) and relatively close genetic relationship with H9N2 viruses identified from poultry in Vietnam and Cambodia in 2015-2017, and all the remaining genes had the highest sequence homologies (99.18 %-99.58 %) and relatively close genetic relationships with H5N8 viruses identified from poultry and waterfowl sampled in African countries in 2017 and swan sampled in China in 2016. Multiple basic amino acids were observed at cleavage sites in the hemagglutinin proteins of the H5N8 isolates, indicating high pathogenicity. In addition, the L89V, G309D, R477G, I495V, A676T and I504V mutations in the polymerase basic 2 protein, N30D and T215A mutations in the matrix 1 protein, P42S mutation, and 80-84 amino acid deletion in the nonstructural 1 protein were detected in all isolates. These mutations were associated with increased virulence and polymerase activity in mammals. Therefore, our results indicate that the H5N8 isolates involved multiple introductions of reassorted viruses, and also revealed that the wetlands of Northern Tianshan Mountain may play a key role in H5N8 AIVs disseminating among Central China, the Eurasian continent, and East African Countries." @default.
• W4200203791 created "2021-12-31" @default.
• W4200203791 creator A5005800628 @default.
• W4200203791 creator A5011304767 @default.
• W4200203791 creator A5026532570 @default.
• W4200203791 creator A5045111481 @default.
• W4200203791 creator A5051345533 @default.
• W4200203791 creator A5060635057 @default.
• W4200203791 creator A5064711465 @default.
• W4200203791 creator A5070180455 @default.
• W4200203791 creator A5075596275 @default.
• W4200203791 creator A5078526337 @default.
• W4200203791 creator A5079289072 @default.
• W4200203791 creator A5087015825 @default.
• W4200203791 date "2022-02-01" @default.
• W4200203791 modified "2023-10-03" @default.
• W4200203791 title "Novel reassortment 2.3.4.4b H5N8 highly pathogenic avian influenza viruses circulating in Xinjiang, China" @default.
• W4200203791 cites W1469673963 @default.
• W4200203791 cites W1973353940 @default.
• W4200203791 cites W1986540197 @default.
• W4200203791 cites W1988533731 @default.
• W4200203791 cites W2011655052 @default.
• W4200203791 cites W2050810682 @default.
• W4200203791 cites W2058180252 @default.
• W4200203791 cites W2069753640 @default.
• W4200203791 cites W2069831575 @default.
• W4200203791 cites W2075665110 @default.
• W4200203791 cites W2092097938 @default.
• W4200203791 cites W2092903823 @default.
• W4200203791 cites W2097341408 @default.
• W4200203791 cites W2099832725 @default.
• W4200203791 cites W2103441770 @default.
• W4200203791 cites W2108234281 @default.
• W4200203791 cites W2112982331 @default.
• W4200203791 cites W2124218461 @default.
• W4200203791 cites W2131314826 @default.
• W4200203791 cites W2158073495 @default.
• W4200203791 cites W2161134800 @default.
• W4200203791 cites W2291125765 @default.
• W4200203791 cites W2532120756 @default.
• W4200203791 cites W2550374335 @default.
• W4200203791 cites W2557499142 @default.
• W4200203791 cites W2564104333 @default.
• W4200203791 cites W2582477906 @default.
• W4200203791 cites W2591584396 @default.
• W4200203791 cites W2605652119 @default.
• W4200203791 cites W2609356370 @default.
• W4200203791 cites W2625671944 @default.
• W4200203791 cites W2727219010 @default.
• W4200203791 cites W2738949405 @default.
• W4200203791 cites W2750825815 @default.
• W4200203791 cites W2752825750 @default.
• W4200203791 cites W2765193895 @default.
• W4200203791 cites W2782326057 @default.
• W4200203791 cites W2791108672 @default.
• W4200203791 cites W2799524357 @default.
• W4200203791 cites W2801130494 @default.
• W4200203791 cites W2807530040 @default.
• W4200203791 cites W2896919500 @default.
• W4200203791 cites W2967162544 @default.
• W4200203791 cites W3092588345 @default.
• W4200203791 cites W3128662309 @default.
• W4200203791 cites W3160857298 @default.
• W4200203791 cites W4210997720 @default.
• W4200203791 doi "https://doi.org/10.1016/j.prevetmed.2021.105564" @default.
• W4200203791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34959041" @default.
• W4200203791 hasPublicationYear "2022" @default.
• W4200203791 type Work @default.
• W4200203791 citedByCount "2" @default.
• W4200203791 countsByYear W42002037912022 @default.
• W4200203791 countsByYear W42002037912023 @default.
• W4200203791 crossrefType "journal-article" @default.
• W4200203791 hasAuthorship W4200203791A5005800628 @default.
• W4200203791 hasAuthorship W4200203791A5011304767 @default.
• W4200203791 hasAuthorship W4200203791A5026532570 @default.
• W4200203791 hasAuthorship W4200203791A5045111481 @default.
• W4200203791 hasAuthorship W4200203791A5051345533 @default.
• W4200203791 hasAuthorship W4200203791A5060635057 @default.
• W4200203791 hasAuthorship W4200203791A5064711465 @default.
• W4200203791 hasAuthorship W4200203791A5070180455 @default.
• W4200203791 hasAuthorship W4200203791A5075596275 @default.
• W4200203791 hasAuthorship W4200203791A5078526337 @default.
• W4200203791 hasAuthorship W4200203791A5079289072 @default.
• W4200203791 hasAuthorship W4200203791A5087015825 @default.
• W4200203791 hasConcept C104317684 @default.
• W4200203791 hasConcept C134164806 @default.
• W4200203791 hasConcept C142724271 @default.
• W4200203791 hasConcept C159047783 @default.
• W4200203791 hasConcept C16154277 @default.
• W4200203791 hasConcept C193252679 @default.
• W4200203791 hasConcept C2522874641 @default.
• W4200203791 hasConcept C2779134260 @default.
• W4200203791 hasConcept C3008058167 @default.
• W4200203791 hasConcept C44465124 @default.
• W4200203791 hasConcept C519248777 @default.
• W4200203791 hasConcept C524204448 @default.
• W4200203791 hasConcept C54355233 @default.
• W4200203791 hasConcept C71924100 @default.

• next