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• W4200205313 abstract "Introduction Cardiac diffusion tensor imaging (DTI) is an emerging technique for the in vivo characterisation of myocardial microstructure, and there is a growing need for its validation and standardisation. We sought to establish accuracy, precision, repeatability and reproducibility of state-of-the-art pulse sequences for cardiac DTI between ten centres internationally. Methods Phantoms comprising 0-20% polyvinylpyrrolidone (PVP) were scanned with DTI using a product pulsed gradient spin echo (PGSE; N=10 sites) sequence, and a custom motion-compensated spin echo (SE; N=5) or stimulated echo (STEAM; N=5) sequence suitable for cardiac DTI in vivo. A second identical scan was performed 1-9 days post, and the data analysed centrally. Results The average mean diffusivities (MD) in 0% PVP were (1.124, 1.130, 1.113) × 10-3 mm2/s for PGSE, SE and STEAM respectively, and accurate to within 1.5% of reference data from literature. The coefficients of variation in MD across sites were 2.6%, 3.1%, 2.1% for PGSE, SE and STEAM, and were similar to previous studies using only PGSE. Reproducibility in MD was excellent, with mean differences in PGSE, SE and STEAM of (0.3 ± 2.3, 0.24 ± 0.95, 0.52 ± 0.58) × 10-5 mm2/s (mean ± 1.96SD). Conclusion We show that custom sequences for cardiac DTI provide accurate, precise, repeatable and reproducible measurements. Further work in anisotropic and/or deforming phantoms is warranted." @default.
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• W4200205313 date "2021-12-29" @default.
• W4200205313 modified "2023-10-18" @default.
• W4200205313 title "Validation of cardiac diffusion tensor imaging sequences: A multi‐centre test‐retest phantom study" @default.
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• W4200205313 doi "https://doi.org/10.1002/nbm.4685" @default.
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