Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200205320> ?p ?o ?g. }
- W4200205320 endingPage "3484" @default.
- W4200205320 startingPage "3484" @default.
- W4200205320 abstract "Many studies support a stepwise continuum of morphologic changes between atypical adenomatous hyperplasia (AAH) and lung adenocarcinoma (ADC). Here we characterized gene expression patterns and the association of differentially expressed genes and immune tumor microenvironment behaviors in AAH to ADC during ADC development. Tumor tissues from nine patients with ADC and synchronous multiple ground glass nodules/lesions (GGN/Ls) were analyzed using RNA sequencing. Using clustering, we identified genes differentially and sequentially expressed in AAH and ADC compared to normal tissues. Functional enrichment analysis using gene ontology terms was performed, and the fraction of immune cell types was estimated. We identified up-regulated genes (ACSL5 and SERINC2) with a stepwise change of expression from AAH to ADC and validated those expressions by quantitative PCR and immunohistochemistry. The immune cell profiles revealed increased B cell activities and decreased natural killer cell activities in AAH and ADC. A stepwise change of differential expression during ADC development revealed potential effects on immune function in synchronous precursors and in tumor lesions in patients with lung cancer." @default.
- W4200205320 created "2021-12-31" @default.
- W4200205320 creator A5000319318 @default.
- W4200205320 creator A5013686145 @default.
- W4200205320 creator A5032303273 @default.
- W4200205320 creator A5037955840 @default.
- W4200205320 creator A5045338711 @default.
- W4200205320 creator A5062716517 @default.
- W4200205320 creator A5070586345 @default.
- W4200205320 creator A5072141209 @default.
- W4200205320 creator A5085898464 @default.
- W4200205320 date "2021-12-10" @default.
- W4200205320 modified "2023-10-17" @default.
- W4200205320 title "Gene Expression Profiles of Multiple Synchronous Lesions in Lung Adenocarcinoma" @default.
- W4200205320 cites W1107917109 @default.
- W4200205320 cites W1778436402 @default.
- W4200205320 cites W1969135135 @default.
- W4200205320 cites W1969937693 @default.
- W4200205320 cites W1990357926 @default.
- W4200205320 cites W1993223855 @default.
- W4200205320 cites W2008387441 @default.
- W4200205320 cites W2044433401 @default.
- W4200205320 cites W2044545697 @default.
- W4200205320 cites W2046810386 @default.
- W4200205320 cites W2049259979 @default.
- W4200205320 cites W2071480068 @default.
- W4200205320 cites W2099755355 @default.
- W4200205320 cites W2101142880 @default.
- W4200205320 cites W2131438131 @default.
- W4200205320 cites W2134526812 @default.
- W4200205320 cites W2147162494 @default.
- W4200205320 cites W2155354546 @default.
- W4200205320 cites W2161042246 @default.
- W4200205320 cites W2179438025 @default.
- W4200205320 cites W2201306698 @default.
- W4200205320 cites W2270237907 @default.
- W4200205320 cites W2338308958 @default.
- W4200205320 cites W2351410734 @default.
- W4200205320 cites W2611596972 @default.
- W4200205320 cites W2747949943 @default.
- W4200205320 cites W2760267264 @default.
- W4200205320 cites W2766676715 @default.
- W4200205320 cites W2766741267 @default.
- W4200205320 cites W2784371446 @default.
- W4200205320 cites W2789878273 @default.
- W4200205320 cites W2798160602 @default.
- W4200205320 cites W2806376789 @default.
- W4200205320 cites W2807141660 @default.
- W4200205320 cites W2886492077 @default.
- W4200205320 cites W2890251329 @default.
- W4200205320 cites W2898412226 @default.
- W4200205320 cites W2947111267 @default.
- W4200205320 cites W3012938208 @default.
- W4200205320 cites W3033905785 @default.
- W4200205320 cites W3119031388 @default.
- W4200205320 cites W3160588558 @default.
- W4200205320 cites W3164361216 @default.
- W4200205320 cites W3197603779 @default.
- W4200205320 cites W3212846163 @default.
- W4200205320 doi "https://doi.org/10.3390/cells10123484" @default.
- W4200205320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34943992" @default.
- W4200205320 hasPublicationYear "2021" @default.
- W4200205320 type Work @default.
- W4200205320 citedByCount "2" @default.
- W4200205320 countsByYear W42002053202022 @default.
- W4200205320 countsByYear W42002053202023 @default.
- W4200205320 crossrefType "journal-article" @default.
- W4200205320 hasAuthorship W4200205320A5000319318 @default.
- W4200205320 hasAuthorship W4200205320A5013686145 @default.
- W4200205320 hasAuthorship W4200205320A5032303273 @default.
- W4200205320 hasAuthorship W4200205320A5037955840 @default.
- W4200205320 hasAuthorship W4200205320A5045338711 @default.
- W4200205320 hasAuthorship W4200205320A5062716517 @default.
- W4200205320 hasAuthorship W4200205320A5070586345 @default.
- W4200205320 hasAuthorship W4200205320A5072141209 @default.
- W4200205320 hasAuthorship W4200205320A5085898464 @default.
- W4200205320 hasBestOaLocation W42002053201 @default.
- W4200205320 hasConcept C104317684 @default.
- W4200205320 hasConcept C121608353 @default.
- W4200205320 hasConcept C126322002 @default.
- W4200205320 hasConcept C142724271 @default.
- W4200205320 hasConcept C150194340 @default.
- W4200205320 hasConcept C203014093 @default.
- W4200205320 hasConcept C204232928 @default.
- W4200205320 hasConcept C2776256026 @default.
- W4200205320 hasConcept C2777714996 @default.
- W4200205320 hasConcept C2779018089 @default.
- W4200205320 hasConcept C2781182431 @default.
- W4200205320 hasConcept C502942594 @default.
- W4200205320 hasConcept C54355233 @default.
- W4200205320 hasConcept C71924100 @default.
- W4200205320 hasConcept C86803240 @default.
- W4200205320 hasConcept C8891405 @default.
- W4200205320 hasConceptScore W4200205320C104317684 @default.
- W4200205320 hasConceptScore W4200205320C121608353 @default.
- W4200205320 hasConceptScore W4200205320C126322002 @default.
- W4200205320 hasConceptScore W4200205320C142724271 @default.
- W4200205320 hasConceptScore W4200205320C150194340 @default.