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- W4200205607 abstract "Imbalanced iron homeostasis plays a crucial role in neurological diseases, yet direct imaging evidence revealing the distribution of active ferrous iron (Fe2+) in the living brain remains scarce. Here, we present a near-infrared excited two-photon fluorescent probe (FeP) for imaging changes of Fe2+ flux in the living epileptic mouse brain. In vivo 3D two-photon brain imaging with FeP directly revealed abnormal elevation of Fe2+ in the epileptic mouse brain. Moreover, we found that dihydroartemisinin (DHA), a lead compound discovered through probe-based high-throughput screening, plays a critical role in modulating iron homeostasis. In addition, we revealed that DHA might exert its antiepileptic effects by modulating iron homeostasis in the brain and finally inhibiting ferroptosis. This work provides a reliable chemical tool for assessing the status of ferrous iron in the living epileptic mouse brain and may aid the rapid discovery of antiepileptic drug candidates." @default.
- W4200205607 created "2021-12-31" @default.
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- W4200205607 date "2022-01-01" @default.
- W4200205607 modified "2023-10-18" @default.
- W4200205607 title "3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis" @default.
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- W4200205607 doi "https://doi.org/10.1016/j.chembiol.2021.12.006" @default.
- W4200205607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34936859" @default.
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