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- W4200207007 abstract "Tumors with loss of breast cancer type 1 susceptibility protein (BRCA1) are homologous recombination (HR) deficient and hypersensitive to poly(ADP-ribose) polymerase inhibitors (PARPi). However, these tumors may restore HR and acquire PARPi resistance via loss of end-protection of DNA double-strand breaks. We found that loss of nuclear DNA ligase III resensitizes HR-restored BRCA1-deficient cells to PARPi by exposing post-replicative single-stranded DNA (ssDNA) gaps. Our work, and that of others, identifies ssDNA gaps as a key determinant of PARPi response." @default.
- W4200207007 created "2021-12-31" @default.
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- W4200207007 date "2021-11-02" @default.
- W4200207007 modified "2023-10-03" @default.
- W4200207007 title "Filling in the gaps in PARP inhibitor-induced synthetic lethality" @default.
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- W4200207007 doi "https://doi.org/10.1080/23723556.2021.2010512" @default.
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