FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200207148> ?p ?o ?g. }

• W4200207148 endingPage "455" @default.
• W4200207148 startingPage "444" @default.
• W4200207148 abstract "A new class of benzimidazole derivatives bearing bis-triazole or bis-thiosemicarbazide structure was designed and synthesized as potential inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase. In vitro EGFR kinase enzyme inhibition properties were determined in comparison with erlotinib and compound (6b) containing propyl side chain at the 4th position of triazole rings showed 13.8% inhibition. Molecular docking studies were performed and docking score and binding energy were established. The most active compound formed a hydrogen bond between the Asn818 and triazole NH at the 2nd position of the benzimidazole skeleton. Predicted ADME profiles of the compounds were calculated and found to be within the appropriate reference ranges." @default.
• W4200207148 created "2021-12-31" @default.
• W4200207148 creator A5000908169 @default.
• W4200207148 creator A5023057502 @default.
• W4200207148 creator A5053866188 @default.
• W4200207148 creator A5077196040 @default.
• W4200207148 creator A5084457457 @default.
• W4200207148 date "2021-12-15" @default.
• W4200207148 modified "2023-10-18" @default.
• W4200207148 title "<i>In Vitro</i> and <i>in Silico</i> Evaluation of Some New 1<i>H</i>-Benzimidazoles Bearing Thiosemicarbazide and Triazole as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor" @default.
• W4200207148 cites W1967394241 @default.
• W4200207148 cites W1974587213 @default.
• W4200207148 cites W1974903851 @default.
• W4200207148 cites W1980192303 @default.
• W4200207148 cites W1999768369 @default.
• W4200207148 cites W1999907087 @default.
• W4200207148 cites W2010053993 @default.
• W4200207148 cites W2012568827 @default.
• W4200207148 cites W2028009636 @default.
• W4200207148 cites W2037188214 @default.
• W4200207148 cites W2058554700 @default.
• W4200207148 cites W2070061090 @default.
• W4200207148 cites W2081764862 @default.
• W4200207148 cites W2098358868 @default.
• W4200207148 cites W2102377211 @default.
• W4200207148 cites W2111025864 @default.
• W4200207148 cites W2162557059 @default.
• W4200207148 cites W2169746118 @default.
• W4200207148 cites W2173513623 @default.
• W4200207148 cites W2399742010 @default.
• W4200207148 cites W2468130466 @default.
• W4200207148 cites W2767183726 @default.
• W4200207148 cites W2770493600 @default.
• W4200207148 cites W2792036853 @default.
• W4200207148 cites W2939466358 @default.
• W4200207148 doi "https://doi.org/10.1080/10406638.2021.2015404" @default.
• W4200207148 hasPublicationYear "2021" @default.
• W4200207148 type Work @default.
• W4200207148 citedByCount "2" @default.
• W4200207148 countsByYear W42002071482022 @default.
• W4200207148 countsByYear W42002071482023 @default.
• W4200207148 crossrefType "journal-article" @default.
• W4200207148 hasAuthorship W4200207148A5000908169 @default.
• W4200207148 hasAuthorship W4200207148A5023057502 @default.
• W4200207148 hasAuthorship W4200207148A5053866188 @default.
• W4200207148 hasAuthorship W4200207148A5077196040 @default.
• W4200207148 hasAuthorship W4200207148A5084457457 @default.
• W4200207148 hasConcept C104317684 @default.
• W4200207148 hasConcept C112887158 @default.
• W4200207148 hasConcept C159110408 @default.
• W4200207148 hasConcept C170493617 @default.
• W4200207148 hasConcept C178790620 @default.
• W4200207148 hasConcept C185592680 @default.
• W4200207148 hasConcept C202751555 @default.
• W4200207148 hasConcept C21951064 @default.
• W4200207148 hasConcept C2775905019 @default.
• W4200207148 hasConcept C2777907353 @default.
• W4200207148 hasConcept C2778087573 @default.
• W4200207148 hasConcept C2778464347 @default.
• W4200207148 hasConcept C2778484023 @default.
• W4200207148 hasConcept C2779438470 @default.
• W4200207148 hasConcept C32909587 @default.
• W4200207148 hasConcept C41685203 @default.
• W4200207148 hasConcept C42362537 @default.
• W4200207148 hasConcept C55493867 @default.
• W4200207148 hasConcept C69366308 @default.
• W4200207148 hasConcept C71240020 @default.
• W4200207148 hasConcept C71924100 @default.
• W4200207148 hasConceptScore W4200207148C104317684 @default.
• W4200207148 hasConceptScore W4200207148C112887158 @default.
• W4200207148 hasConceptScore W4200207148C159110408 @default.
• W4200207148 hasConceptScore W4200207148C170493617 @default.
• W4200207148 hasConceptScore W4200207148C178790620 @default.
• W4200207148 hasConceptScore W4200207148C185592680 @default.
• W4200207148 hasConceptScore W4200207148C202751555 @default.
• W4200207148 hasConceptScore W4200207148C21951064 @default.
• W4200207148 hasConceptScore W4200207148C2775905019 @default.
• W4200207148 hasConceptScore W4200207148C2777907353 @default.
• W4200207148 hasConceptScore W4200207148C2778087573 @default.
• W4200207148 hasConceptScore W4200207148C2778464347 @default.
• W4200207148 hasConceptScore W4200207148C2778484023 @default.
• W4200207148 hasConceptScore W4200207148C2779438470 @default.
• W4200207148 hasConceptScore W4200207148C32909587 @default.
• W4200207148 hasConceptScore W4200207148C41685203 @default.
• W4200207148 hasConceptScore W4200207148C42362537 @default.
• W4200207148 hasConceptScore W4200207148C55493867 @default.
• W4200207148 hasConceptScore W4200207148C69366308 @default.
• W4200207148 hasConceptScore W4200207148C71240020 @default.
• W4200207148 hasConceptScore W4200207148C71924100 @default.
• W4200207148 hasFunder F4320306416 @default.
• W4200207148 hasFunder F4320309936 @default.
• W4200207148 hasIssue "1" @default.
• W4200207148 hasLocation W42002071481 @default.
• W4200207148 hasOpenAccess W4200207148 @default.
• W4200207148 hasPrimaryLocation W42002071481 @default.
• W4200207148 hasRelatedWork W2035922710 @default.
• W4200207148 hasRelatedWork W2898169309 @default.
• W4200207148 hasRelatedWork W2939466358 @default.

• next