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• W4200207651 abstract "<ns4:p><ns4:bold>Background</ns4:bold>: The study aimed to examine the effect of administering CHAGURO (a product of the combination of siamese pumpkin and tuna-based powder) on the lipid profile in prediabetes individuals with dyslipidemia.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: The experimental trial was conducted with two intervention groups, with each group receiving a dose of 7.5g/70kg body weight (BW)/day (low dose) and 15g/70kg BW/day (high dose) for 60 days. Respondents were randomized into intervention groups using simple randomization. Before and after the intervention, pre-test and post-test examinations were performed, factors examined included hemoglobin A1c (HbA1c), lipid profile, blood pressure, eating intake with the SQ-FFQ (Semi Quantitative-Food Frequency Questionnaire) interview, body mass index (BMI), and physical activity using InternationalPhysical Activity Questionnaires-Short Form (IPAQ-SF). During the intervention, blood pressure and BMI data were taken before and after the study. Statistical analysis included descriptive tests, independent and paired T-tests, and analysis of variance (ANOVA).</ns4:p><ns4:p> <ns4:bold>Results</ns4:bold>: Compared to the baseline, HbA1c, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides in the two groups did not improve significantly by 60 days. For lipid variables, a significant improvement in the cholesterol/high-density lipoprotein (chol/HDL) ratios were observed when compared against the baseline for the two groups. When comparing the changes between groups, 7.5 g of CHAGURO showed a larger improvement in HDL-C (mean differences: 1.86 mg/dL; 95% CI: -0.86-4.59), compared to 15 g of CHAGURO (mean differences: -3.62 mg/dL; 95% CI: -7.53-0.28). A significant (p<0.05) decrease in the chol/HDL ratio was observed in the 7.5 g CHAGURO group (mean differences: -0.20 mg/dL; 95% CI: -0.39-(-0.01)).</ns4:p><ns4:p> <ns4:bold>Conclusions</ns4:bold>: CHAGURO can be a functional food alternative to improve the condition of prediabetes people with dyslipidemia.</ns4:p><ns4:p> <ns4:bold>Trial registration: </ns4:bold>Dr. Sardjito General Hospital (KE/FK/0951/EC/2020), 27/08/2020</ns4:p>" @default.
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• W4200207651 date "2021-12-20" @default.
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• W4200207651 title "The effect of a siamese pumpkin and tuna-based powder (CHAGURO) diet in improving HbA1c, HDL-C, and chol/HDL ratios in prediabetes individuals with dyslipidemia: a randomised trial" @default.
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• W4200207651 doi "https://doi.org/10.12688/f1000research.75131.1" @default.
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