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- W4200208019 abstract "Abstract Background : Ovarian serous cystadenocarcinoma (OC) is a common malignant gynecological tumor that is found in women. Metastasis of ovarian cancer cells are the main causes of poor prognosis. Cell-acquired invasiveness is accompanied by the loss of epithelial features and gain of a mesenchymal phenotype, through a process known as epithelial–mesenchymal transition (EMT). Circular RNAs (circRNAs) are important biological molecules that are associated with pathogenesis of Multiple cancers; however, the roles of circRNAs and EMT in OC remain unclear. Methods : Using circRNA microarray, the circRNA expression profiles in ovarian tissues, with and without OC, were identified and verified using quantitative reverse transcription PCR (RT-qPCR). The effects of circ_0070203, miR-370-3p, and TGFβR2 on SKOV-3 cell migration and invasion were evaluated. The binding sites between circ_0070203, miR-370-3p, and TGFβR2 were verified by dual-luciferase reporter assay and bioinformatics analysis. The expression levels of epithelial mesenchymal transformation-related proteins were detected by western blotting. Cell migration and invasion were analyzed by a transwell assay. Results: Circ_0070203 and TGFβR2 were upregulated, while miR-370-3p was downregulated in OC and SKOV-3 cell lines. The overexpression of circ_0070203 changed the expression of other EMT-related proteins, and enhanced the invasion and migration abilities of ovarian cancer cells. The inhibitory effect of circ_0070203 knockdown on EMT, migration, and invasion of ovarian cancer cells was partly attenuated by an miR-370-3p inhibitor. Conclusion : Circ_0070203 promotes epithelial mesenchymal transformation, invasion, and metastasis of ovarian cancer cells via the miR-370-3p /TGFβR2 axis." @default.
- W4200208019 created "2021-12-31" @default.
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- W4200208019 date "2021-11-16" @default.
- W4200208019 modified "2023-09-27" @default.
- W4200208019 title "Circ_0070203 Promotes Epithelial Mesenchymal Transition in Ovarian Serous Cystadenocarcinoma through miR-370-3p/TGFβR2 Axis" @default.
- W4200208019 doi "https://doi.org/10.21203/rs.3.rs-1036753/v1" @default.
- W4200208019 hasPublicationYear "2021" @default.
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