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- W4200208032 abstract "Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E-G (1a-3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive." @default.
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- W4200208032 date "2021-12-20" @default.
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- W4200208032 title "Mansouramycins E–G, Cytotoxic Isoquinolinequinones from Marine Streptomycetes" @default.
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- W4200208032 doi "https://doi.org/10.3390/md19120715" @default.
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