FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200208542> ?p ?o ?g. }

• W4200208542 abstract "This study was designed to investigate the mechanism and effects of miRNA-221-5p on the T-helper 17 (Th17)/T-regulatory (Treg) ratio in asthma.BALB/c mice were intranasally challenged with 100 µg OVA on 14 and 21 day. Mice were rechallenged with 2.5% OVA-PBS on 22 and 28 day. Mice were sacrificed using on day 30 under 35 mg/kg pentobarbital sodium. PBMCs were induced vitro model of asthma using 500 ng of lipopolysaccharides (LPS) for 4 h.The expression of miRNA-221-5p was reduced in in vivo model, compared sham group. The vitro model of asthma treated with miRNA-221-5p mimic resulted in the reduction of IL-6, IL-17, IL-21 and IL-22 levels, and induction of IL-10, IL-35 and TGF-β levels. In addition, down-regulation of miRNA-221-5p induced the protein expression of suppressor of cytokine signaling 1 (SOCS1) and receptor-related orphan receptor-gamma-t (RORγt) and suppressed that of FOXP3 in in vitro model of asthma. Over-expression of miRNA-221-5p induced the protein expression of FOXP3, and suppressed that of SOCS1 and RORγt in in vitro model of asthma. The inhibition of SOCS1 or RORγt attenuated the effects of anti-miRNA-221-5p on Th17/Treg ratio in asthma.miRNA-221-5p may play critical roles in driving the differentiation of Th17/Treg ratio via RORγt/Foxp3 by Targeting SOCS1, reduced the function of Th17 cells by directly inhibiting RORγt/SOCS1 and promoted the function of Treg cells via Foxp3/ SOCS1 in asthma." @default.
• W4200208542 created "2021-12-31" @default.
• W4200208542 creator A5029067578 @default.
• W4200208542 creator A5030090275 @default.
• W4200208542 creator A5058259220 @default.
• W4200208542 creator A5062127574 @default.
• W4200208542 creator A5077385497 @default.
• W4200208542 creator A5087240893 @default.
• W4200208542 date "2021-12-01" @default.
• W4200208542 modified "2023-10-16" @default.
• W4200208542 title "MiRNA-221-5p suppressed the Th17/Treg ratio in asthma via RORγt/Foxp3 by targeting SOCS1" @default.
• W4200208542 cites W2015848648 @default.
• W4200208542 cites W2032051864 @default.
• W4200208542 cites W2088579093 @default.
• W4200208542 cites W2101437655 @default.
• W4200208542 cites W2107277218 @default.
• W4200208542 cites W2163700034 @default.
• W4200208542 cites W2201644756 @default.
• W4200208542 cites W2247454121 @default.
• W4200208542 cites W2271955507 @default.
• W4200208542 cites W2561054909 @default.
• W4200208542 cites W2594008074 @default.
• W4200208542 cites W2623461161 @default.
• W4200208542 cites W2737969333 @default.
• W4200208542 cites W2742944258 @default.
• W4200208542 cites W2744118542 @default.
• W4200208542 cites W2753261534 @default.
• W4200208542 cites W2767548441 @default.
• W4200208542 cites W2770371481 @default.
• W4200208542 cites W2792039041 @default.
• W4200208542 cites W2795067285 @default.
• W4200208542 doi "https://doi.org/10.1186/s13223-021-00620-8" @default.
• W4200208542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34863307" @default.
• W4200208542 hasPublicationYear "2021" @default.
• W4200208542 type Work @default.
• W4200208542 citedByCount "7" @default.
• W4200208542 countsByYear W42002085422022 @default.
• W4200208542 countsByYear W42002085422023 @default.
• W4200208542 crossrefType "journal-article" @default.
• W4200208542 hasAuthorship W4200208542A5029067578 @default.
• W4200208542 hasAuthorship W4200208542A5030090275 @default.
• W4200208542 hasAuthorship W4200208542A5058259220 @default.
• W4200208542 hasAuthorship W4200208542A5062127574 @default.
• W4200208542 hasAuthorship W4200208542A5077385497 @default.
• W4200208542 hasAuthorship W4200208542A5087240893 @default.
• W4200208542 hasBestOaLocation W42002085421 @default.
• W4200208542 hasConcept C104317684 @default.
• W4200208542 hasConcept C121608353 @default.
• W4200208542 hasConcept C126322002 @default.
• W4200208542 hasConcept C14077384 @default.
• W4200208542 hasConcept C145059251 @default.
• W4200208542 hasConcept C170493617 @default.
• W4200208542 hasConcept C179185449 @default.
• W4200208542 hasConcept C185592680 @default.
• W4200208542 hasConcept C202751555 @default.
• W4200208542 hasConcept C203014093 @default.
• W4200208542 hasConcept C2778690821 @default.
• W4200208542 hasConcept C2779161069 @default.
• W4200208542 hasConcept C2779727006 @default.
• W4200208542 hasConcept C55493867 @default.
• W4200208542 hasConcept C71924100 @default.
• W4200208542 hasConcept C74737994 @default.
• W4200208542 hasConcept C86339819 @default.
• W4200208542 hasConcept C8891405 @default.
• W4200208542 hasConceptScore W4200208542C104317684 @default.
• W4200208542 hasConceptScore W4200208542C121608353 @default.
• W4200208542 hasConceptScore W4200208542C126322002 @default.
• W4200208542 hasConceptScore W4200208542C14077384 @default.
• W4200208542 hasConceptScore W4200208542C145059251 @default.
• W4200208542 hasConceptScore W4200208542C170493617 @default.
• W4200208542 hasConceptScore W4200208542C179185449 @default.
• W4200208542 hasConceptScore W4200208542C185592680 @default.
• W4200208542 hasConceptScore W4200208542C202751555 @default.
• W4200208542 hasConceptScore W4200208542C203014093 @default.
• W4200208542 hasConceptScore W4200208542C2778690821 @default.
• W4200208542 hasConceptScore W4200208542C2779161069 @default.
• W4200208542 hasConceptScore W4200208542C2779727006 @default.
• W4200208542 hasConceptScore W4200208542C55493867 @default.
• W4200208542 hasConceptScore W4200208542C71924100 @default.
• W4200208542 hasConceptScore W4200208542C74737994 @default.
• W4200208542 hasConceptScore W4200208542C86339819 @default.
• W4200208542 hasConceptScore W4200208542C8891405 @default.
• W4200208542 hasIssue "1" @default.
• W4200208542 hasLocation W42002085421 @default.
• W4200208542 hasLocation W42002085422 @default.
• W4200208542 hasLocation W42002085423 @default.
• W4200208542 hasLocation W42002085424 @default.
• W4200208542 hasOpenAccess W4200208542 @default.
• W4200208542 hasPrimaryLocation W42002085421 @default.
• W4200208542 hasRelatedWork W2033215494 @default.
• W4200208542 hasRelatedWork W2156692908 @default.
• W4200208542 hasRelatedWork W2526529070 @default.
• W4200208542 hasRelatedWork W2528958477 @default.
• W4200208542 hasRelatedWork W2553004139 @default.
• W4200208542 hasRelatedWork W2743830506 @default.
• W4200208542 hasRelatedWork W2784730176 @default.
• W4200208542 hasRelatedWork W2792392350 @default.
• W4200208542 hasRelatedWork W4200208542 @default.
• W4200208542 hasRelatedWork W2185888096 @default.
• W4200208542 hasVolume "17" @default.

• next