Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200209323> ?p ?o ?g. }
- W4200209323 endingPage "1103" @default.
- W4200209323 startingPage "1090" @default.
- W4200209323 abstract "The scaffold microstructure is important for bone tissue engineering. Failure to synergistically imitate the hierarchical microstructure of the components of bone, such as an osteon with concentric multilayers assembled by nanofibers, hinders the performance for guiding bone regeneration. Here, a 2D bilayer nanofibrous membrane (BLM) containing poly(lactide-co-glycolide) (PLGA)/polycaprolactone (PCL) composite membranes in similar compositions (PCL15 and PCL20), but possessing different degrees of shrinkage, was fabricated via sequential electrospinning. Upon incubation in phosphate buffered saline (PBS) (37 °C), the 2D BLM spontaneously deformed into a 3D shape induced by PCL crystallization within the PLGA matrix, and the PCL15 and PCL20 layer formed a concave and convex surface, respectively. The 3D structure contained curved multilayers with an average diameter of 776 ± 169 μm, and on the concave and convex surface the nanofiber diameters were 792 ± 225 and 881 ± 259 nm, respectively. The initial 2D structure facilitated the even distribution of seeded cells. Adipose-derived stem cells from rats (rADSCs) proliferated faster on a concave surface than on a convex surface. For the 3D BLM, the osteogenic differentiation of rADSCs was significantly higher than that on 2D surfaces, even without osteogenic supplements, which resulted from the stretched cell morphology on the curved sublayer leading to increased expression of lamin-A. After being implanted into cranial defects in Sprague Dawley (SD) rats, 3D BLM significantly accelerated bone formation. In summary, 3D BLM with an osteon-like structure provides a potential strategy to repair bone defects." @default.
- W4200209323 created "2021-12-31" @default.
- W4200209323 creator A5000859290 @default.
- W4200209323 creator A5001465349 @default.
- W4200209323 creator A5026566946 @default.
- W4200209323 creator A5051756911 @default.
- W4200209323 creator A5054844187 @default.
- W4200209323 creator A5077242615 @default.
- W4200209323 creator A5082970770 @default.
- W4200209323 date "2022-01-01" @default.
- W4200209323 modified "2023-10-16" @default.
- W4200209323 title "Osteon-mimetic 3D nanofibrous scaffold enhances stem cell proliferation and osteogenic differentiation for bone regeneration" @default.
- W4200209323 cites W1772547922 @default.
- W4200209323 cites W1851542016 @default.
- W4200209323 cites W1919623402 @default.
- W4200209323 cites W1990285819 @default.
- W4200209323 cites W2004000166 @default.
- W4200209323 cites W2030637965 @default.
- W4200209323 cites W2032741311 @default.
- W4200209323 cites W2047997264 @default.
- W4200209323 cites W2049906701 @default.
- W4200209323 cites W2068206834 @default.
- W4200209323 cites W2085458126 @default.
- W4200209323 cites W2119838587 @default.
- W4200209323 cites W2130594839 @default.
- W4200209323 cites W2165707177 @default.
- W4200209323 cites W2171283890 @default.
- W4200209323 cites W2171902254 @default.
- W4200209323 cites W2182667787 @default.
- W4200209323 cites W2283156410 @default.
- W4200209323 cites W2284242382 @default.
- W4200209323 cites W2335363879 @default.
- W4200209323 cites W2346329785 @default.
- W4200209323 cites W2404186446 @default.
- W4200209323 cites W2419334137 @default.
- W4200209323 cites W2467765583 @default.
- W4200209323 cites W2591475317 @default.
- W4200209323 cites W2610551227 @default.
- W4200209323 cites W2611042837 @default.
- W4200209323 cites W2744473680 @default.
- W4200209323 cites W2749750820 @default.
- W4200209323 cites W2759874663 @default.
- W4200209323 cites W2776129144 @default.
- W4200209323 cites W2792042271 @default.
- W4200209323 cites W2793383496 @default.
- W4200209323 cites W2891678928 @default.
- W4200209323 cites W2914265040 @default.
- W4200209323 cites W2947977408 @default.
- W4200209323 cites W2949748279 @default.
- W4200209323 cites W2960571250 @default.
- W4200209323 cites W2968997612 @default.
- W4200209323 cites W2973183603 @default.
- W4200209323 cites W2996426436 @default.
- W4200209323 cites W3000499424 @default.
- W4200209323 cites W3006287442 @default.
- W4200209323 cites W3009257182 @default.
- W4200209323 cites W3014307134 @default.
- W4200209323 cites W3027866862 @default.
- W4200209323 cites W3039603742 @default.
- W4200209323 cites W3128920319 @default.
- W4200209323 cites W3145295942 @default.
- W4200209323 cites W3158131307 @default.
- W4200209323 cites W3158217187 @default.
- W4200209323 cites W3159119403 @default.
- W4200209323 cites W3164345648 @default.
- W4200209323 cites W3196434765 @default.
- W4200209323 cites W3208265643 @default.
- W4200209323 doi "https://doi.org/10.1039/d1bm01489g" @default.
- W4200209323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35040827" @default.
- W4200209323 hasPublicationYear "2022" @default.
- W4200209323 type Work @default.
- W4200209323 citedByCount "10" @default.
- W4200209323 countsByYear W42002093232022 @default.
- W4200209323 countsByYear W42002093232023 @default.
- W4200209323 crossrefType "journal-article" @default.
- W4200209323 hasAuthorship W4200209323A5000859290 @default.
- W4200209323 hasAuthorship W4200209323A5001465349 @default.
- W4200209323 hasAuthorship W4200209323A5026566946 @default.
- W4200209323 hasAuthorship W4200209323A5051756911 @default.
- W4200209323 hasAuthorship W4200209323A5054844187 @default.
- W4200209323 hasAuthorship W4200209323A5077242615 @default.
- W4200209323 hasAuthorship W4200209323A5082970770 @default.
- W4200209323 hasConcept C105702510 @default.
- W4200209323 hasConcept C12554922 @default.
- W4200209323 hasConcept C136229726 @default.
- W4200209323 hasConcept C144796933 @default.
- W4200209323 hasConcept C155672457 @default.
- W4200209323 hasConcept C159985019 @default.
- W4200209323 hasConcept C171056886 @default.
- W4200209323 hasConcept C171250308 @default.
- W4200209323 hasConcept C185592680 @default.
- W4200209323 hasConcept C192562407 @default.
- W4200209323 hasConcept C2777909254 @default.
- W4200209323 hasConcept C2779868350 @default.
- W4200209323 hasConcept C2780165375 @default.
- W4200209323 hasConcept C2781451080 @default.
- W4200209323 hasConcept C521977710 @default.
- W4200209323 hasConcept C71924100 @default.