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- W4200210923 abstract "One of the most challenging aspects of clinical pharmacology and pharmacoepidemiology is to understand why individuals and groups of individuals respond differently to a specific drug therapy, both in terms of beneficial and adverse effects. Genetic variability can account for a large proportion of variability in drug disposition and medication effects. The complexity of genome structure and genetic variability that influences response to medications provides unique challenges to molecular pharmacoepidemiology. Pharmacogenetic and pharmacogenomic studies are usually designed to examine intermediate endpoints between drugs and outcomes and rely on detailed measurements of these surrogates in small groups of patients in highly controlled settings. Genetic variability in disease states also can be critical for tailoring drug therapy to patients with a specific genotype related both to the disease and drug response. The chapter focuses on the methodological challenges of studying interactions, minimizing type I and type II errors, and accounting for confounding, particularly by population admixture." @default.
- W4200210923 created "2021-12-31" @default.
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- W4200210923 date "2021-11-15" @default.
- W4200210923 modified "2023-09-24" @default.
- W4200210923 title "Molecular Pharmacoepidemiology" @default.
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- W4200210923 doi "https://doi.org/10.1002/9781119701101.ch15" @default.
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