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- W4200211389 abstract "ObjectiveIn this methodologic study (Part 1 of 2), we examined methods used to assess harms in systematic reviews and meta-analyses (SRMAs) of gabapentin. We compared methods used with current recommendations for synthesizing harms. Study Design & SettingWe followed recommended systematic review practices. We selected reliable SRMAs of gabapentin (i.e., met a pre-defined list of methodological criteria) that assessed at least one harm. We extracted and compared methods in four areas: pre-specification, searching, analysis, and reporting. Whereas our focus in this paper is on the methods used, Part 2 examines the results for harms across reviews. ResultsWe screened 4320 records and identified 157 SRMAs of gabapentin, 70 of which were reliable. Most reliable reviews (51/70; 73%) reported following a general guideline for SRMA conduct or reporting, but none reported following recommendations specifically for synthesizing harms. Across all domains assessed, review methods were designed to address questions of benefit and rarely included the additional methods that are recommended for evaluating harms. ConclusionApproaches to assessing harms in SRMAs we examined are tokenistic and unlikely to produce valid summaries of harms to guide decisions. A paradigm shift is needed. At a minimal, reviewers should describe any limitations to their assessment of harms and provide clearer descriptions of methods for synthesizing harms." @default.
- W4200211389 created "2021-12-31" @default.
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- W4200211389 date "2021-10-01" @default.
- W4200211389 modified "2023-09-26" @default.
- W4200211389 title "Summaries of harms in systematic reviews are unreliable (Part 1 of 2): Methods used to assess harms are neglected in systematic reviews of gabapentin" @default.
- W4200211389 doi "https://doi.org/10.31219/osf.io/7g4ez" @default.
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