Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200212246> ?p ?o ?g. }
- W4200212246 abstract "Conventional DNA vaccine strategies usually employ a regimen of immunizations at 2-week or longer intervals to induce effective memory cell-dependent immune responses. Clinical cancer treatment requires a faster immunization strategy to contend with tumor progression. In this study, a novel fast immunization strategy was established, wherein a DNA vaccine was intramuscularly administered on days 0, 2, and 5 in a murine lung cancer model. Effector cells peaked 7 to 10 days after the last vaccination. Compared with traditional 2-week-interval immunization strategies, antigen-specific cytolysis and INF-γ secretion were significantly enhanced under the fast vaccination approach. As a result, the rapidly administered DNA vaccine elicited stronger and more prompt antitumor effects. The probable underlying mechanism of fast immunization was the accumulation of CD8+CD11c+ antigen-presenting cells at the injection site, which enhanced subsequent antigen presentation. In conclusion, the fast DNA vaccination strategy shortened vaccination time to 5 days and elicited a stronger antitumor immune response." @default.
- W4200212246 created "2021-12-31" @default.
- W4200212246 creator A5000479471 @default.
- W4200212246 creator A5011157307 @default.
- W4200212246 creator A5023858361 @default.
- W4200212246 creator A5032109161 @default.
- W4200212246 creator A5032257574 @default.
- W4200212246 creator A5047579560 @default.
- W4200212246 creator A5051613807 @default.
- W4200212246 creator A5062041944 @default.
- W4200212246 creator A5070433780 @default.
- W4200212246 creator A5074673516 @default.
- W4200212246 creator A5075115724 @default.
- W4200212246 creator A5077749470 @default.
- W4200212246 creator A5085796521 @default.
- W4200212246 creator A5086632320 @default.
- W4200212246 date "2021-12-07" @default.
- W4200212246 modified "2023-10-13" @default.
- W4200212246 title "Fast DNA Vaccination Strategy Elicits a Stronger Immune Response Dependent on CD8+CD11c+ Cell Accumulation" @default.
- W4200212246 cites W1556818178 @default.
- W4200212246 cites W1932988878 @default.
- W4200212246 cites W1964266353 @default.
- W4200212246 cites W1979195886 @default.
- W4200212246 cites W2005664558 @default.
- W4200212246 cites W2009897979 @default.
- W4200212246 cites W2014495927 @default.
- W4200212246 cites W2031172509 @default.
- W4200212246 cites W2033484017 @default.
- W4200212246 cites W2071124717 @default.
- W4200212246 cites W2162875441 @default.
- W4200212246 cites W2198678042 @default.
- W4200212246 cites W2265419075 @default.
- W4200212246 cites W2405538065 @default.
- W4200212246 cites W2531246324 @default.
- W4200212246 cites W2564433363 @default.
- W4200212246 cites W2586862787 @default.
- W4200212246 cites W2587055344 @default.
- W4200212246 cites W2588118089 @default.
- W4200212246 cites W2611361945 @default.
- W4200212246 cites W2728365508 @default.
- W4200212246 cites W2729927816 @default.
- W4200212246 cites W2751967109 @default.
- W4200212246 cites W2765736556 @default.
- W4200212246 cites W2770500213 @default.
- W4200212246 cites W2780166051 @default.
- W4200212246 cites W2793334672 @default.
- W4200212246 cites W2795293588 @default.
- W4200212246 cites W2805602768 @default.
- W4200212246 cites W2896837325 @default.
- W4200212246 cites W2904968070 @default.
- W4200212246 cites W2905644126 @default.
- W4200212246 cites W2912067875 @default.
- W4200212246 cites W2913314727 @default.
- W4200212246 cites W2945080083 @default.
- W4200212246 cites W2949793585 @default.
- W4200212246 cites W2961737246 @default.
- W4200212246 cites W2971741532 @default.
- W4200212246 cites W2982242906 @default.
- W4200212246 cites W2982252373 @default.
- W4200212246 cites W2991080419 @default.
- W4200212246 cites W3017095108 @default.
- W4200212246 cites W3030184127 @default.
- W4200212246 cites W3038037714 @default.
- W4200212246 cites W3093270998 @default.
- W4200212246 cites W3094546549 @default.
- W4200212246 cites W3098875123 @default.
- W4200212246 cites W3157513056 @default.
- W4200212246 doi "https://doi.org/10.3389/fonc.2021.752444" @default.
- W4200212246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34950581" @default.
- W4200212246 hasPublicationYear "2021" @default.
- W4200212246 type Work @default.
- W4200212246 citedByCount "1" @default.
- W4200212246 countsByYear W42002122462023 @default.
- W4200212246 crossrefType "journal-article" @default.
- W4200212246 hasAuthorship W4200212246A5000479471 @default.
- W4200212246 hasAuthorship W4200212246A5011157307 @default.
- W4200212246 hasAuthorship W4200212246A5023858361 @default.
- W4200212246 hasAuthorship W4200212246A5032109161 @default.
- W4200212246 hasAuthorship W4200212246A5032257574 @default.
- W4200212246 hasAuthorship W4200212246A5047579560 @default.
- W4200212246 hasAuthorship W4200212246A5051613807 @default.
- W4200212246 hasAuthorship W4200212246A5062041944 @default.
- W4200212246 hasAuthorship W4200212246A5070433780 @default.
- W4200212246 hasAuthorship W4200212246A5074673516 @default.
- W4200212246 hasAuthorship W4200212246A5075115724 @default.
- W4200212246 hasAuthorship W4200212246A5077749470 @default.
- W4200212246 hasAuthorship W4200212246A5085796521 @default.
- W4200212246 hasAuthorship W4200212246A5086632320 @default.
- W4200212246 hasBestOaLocation W42002122461 @default.
- W4200212246 hasConcept C147483822 @default.
- W4200212246 hasConcept C154317977 @default.
- W4200212246 hasConcept C167508917 @default.
- W4200212246 hasConcept C167672396 @default.
- W4200212246 hasConcept C202751555 @default.
- W4200212246 hasConcept C203014093 @default.
- W4200212246 hasConcept C22070199 @default.
- W4200212246 hasConcept C2780801004 @default.
- W4200212246 hasConcept C55493867 @default.
- W4200212246 hasConcept C71924100 @default.
- W4200212246 hasConcept C73588182 @default.