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- W4200212410 endingPage "114895" @default.
- W4200212410 startingPage "114895" @default.
- W4200212410 abstract "Amlexanox (AMX) is an azoxanthone drug used for decades for the treatment of mouth aphthous ulcers and now considered for the treatment of diabetes and obesity. The drug is usually viewed as a dual inhibitor of the non-canonical IκB kinases IKK-ɛ (inhibitor-kappaB kinase epsilon) and TBK1 (TANK-binding kinase 1). But a detailed target profile analysis indicated that AMX binds directly to twelve protein targets, including different enzymes (IKK-ɛ, TBK1, GRK1, GRK5, PDE4B, 5- and 12-lipoxygenases) and non-enzyme proteins (FGF-1, HSP90, S100A4, S100A12, S100A13). AMX has been demonstrated to have marked anticancer effects in multiple models of xenografted tumors in mice, including breast, colon, lung and gastric cancers and in onco-hematological models. The anticancer potency is generally modest but largely enhanced upon combination with cytotoxic (temozolide, docetaxel), targeted (selumetinib) or biotherapeutic agents (anti-PD-1 and anti-CTLA4 antibodies). The multiple targets participate in the anticancer effects, chiefly IKK-ɛ/TBK1 but also S100A proteins and PDE4B. The review presents the molecular basis of the antitumor effects of AMX. The capacity of the drug to block nonsense-mediated mRNA decay (NMD) is also discussed, as well as AMX-induced reduction of cancer-related pain. Altogether, the analysis provides a survey of the anticancer action of AMX, with the implicated protein targets. The use of this well-tolerated drug to treat cancer should be further considered and the design of newer analogues encouraged." @default.
- W4200212410 created "2021-12-31" @default.
- W4200212410 creator A5073920505 @default.
- W4200212410 date "2022-03-01" @default.
- W4200212410 modified "2023-10-17" @default.
- W4200212410 title "The potential value of amlexanox in the treatment of cancer: Molecular targets and therapeutic perspectives" @default.
- W4200212410 cites W1275683271 @default.
- W4200212410 cites W1574068022 @default.
- W4200212410 cites W166140032 @default.
- W4200212410 cites W1982652661 @default.
- W4200212410 cites W1983732891 @default.
- W4200212410 cites W1997071064 @default.
- W4200212410 cites W2001661644 @default.
- W4200212410 cites W2027255898 @default.
- W4200212410 cites W2033629089 @default.
- W4200212410 cites W2039235909 @default.
- W4200212410 cites W2048399724 @default.
- W4200212410 cites W2048793216 @default.
- W4200212410 cites W2053615699 @default.
- W4200212410 cites W2055484555 @default.
- W4200212410 cites W2071361613 @default.
- W4200212410 cites W2075725934 @default.
- W4200212410 cites W2078484763 @default.
- W4200212410 cites W2079332279 @default.
- W4200212410 cites W2083318555 @default.
- W4200212410 cites W2089453874 @default.
- W4200212410 cites W2091800772 @default.
- W4200212410 cites W2100252315 @default.
- W4200212410 cites W2107031305 @default.
- W4200212410 cites W2107584818 @default.
- W4200212410 cites W2107933391 @default.
- W4200212410 cites W2112233347 @default.
- W4200212410 cites W2130461300 @default.
- W4200212410 cites W2132358139 @default.
- W4200212410 cites W2134743382 @default.
- W4200212410 cites W2136485169 @default.
- W4200212410 cites W2144787399 @default.
- W4200212410 cites W2147592527 @default.
- W4200212410 cites W2166747120 @default.
- W4200212410 cites W2184423981 @default.
- W4200212410 cites W2233122173 @default.
- W4200212410 cites W2254527099 @default.
- W4200212410 cites W2297927800 @default.
- W4200212410 cites W2318173327 @default.
- W4200212410 cites W2330327728 @default.
- W4200212410 cites W2336389295 @default.
- W4200212410 cites W2410408354 @default.
- W4200212410 cites W2471478626 @default.
- W4200212410 cites W2474431507 @default.
- W4200212410 cites W2512289640 @default.
- W4200212410 cites W2518106500 @default.
- W4200212410 cites W2524952974 @default.
- W4200212410 cites W2615122877 @default.
- W4200212410 cites W2619627699 @default.
- W4200212410 cites W2620846231 @default.
- W4200212410 cites W2687837611 @default.
- W4200212410 cites W2725509061 @default.
- W4200212410 cites W2751629076 @default.
- W4200212410 cites W2766123339 @default.
- W4200212410 cites W2767309126 @default.
- W4200212410 cites W2783053138 @default.
- W4200212410 cites W2797530491 @default.
- W4200212410 cites W2886595753 @default.
- W4200212410 cites W2887102096 @default.
- W4200212410 cites W2889752068 @default.
- W4200212410 cites W2890787608 @default.
- W4200212410 cites W2890966771 @default.
- W4200212410 cites W2896592854 @default.
- W4200212410 cites W2903213274 @default.
- W4200212410 cites W2903891108 @default.
- W4200212410 cites W2904381205 @default.
- W4200212410 cites W2908665740 @default.
- W4200212410 cites W2916816219 @default.
- W4200212410 cites W2918295483 @default.
- W4200212410 cites W2918569429 @default.
- W4200212410 cites W2953489385 @default.
- W4200212410 cites W2982455170 @default.
- W4200212410 cites W2982553009 @default.
- W4200212410 cites W2982628996 @default.
- W4200212410 cites W2983001237 @default.
- W4200212410 cites W2991240508 @default.
- W4200212410 cites W2994955008 @default.
- W4200212410 cites W3000333037 @default.
- W4200212410 cites W3004946110 @default.
- W4200212410 cites W3009009261 @default.
- W4200212410 cites W3010933437 @default.
- W4200212410 cites W3011178559 @default.
- W4200212410 cites W3012024185 @default.
- W4200212410 cites W3013816010 @default.
- W4200212410 cites W3021363784 @default.
- W4200212410 cites W3026238348 @default.
- W4200212410 cites W3033190597 @default.
- W4200212410 cites W3040604727 @default.
- W4200212410 cites W3044059477 @default.
- W4200212410 cites W3081485102 @default.
- W4200212410 cites W3082365396 @default.
- W4200212410 cites W3108579746 @default.
- W4200212410 cites W3119138534 @default.