FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200213229> ?p ?o ?g. }

• W4200213229 abstract "<h3>Background</h3> Long-term glucocorticoid therapy with Prednisolone or Deflazacort has improved outcomes in patients with Duchenne Muscular Dystrophy (DMD), however recommended dosages suppress the hypothalamic-pituitary-adrenal axis, leading to adrenal insufficiency. All boys prescribed glucocorticoid therapy should be assumed to have adrenal suppression, and therefore at risk of adrenal crisis during illness or stress. The updated DMD Care Considerations consensus document (2018) recommends implementation of emergency plans. However, no unified national or international guidance for illness management for this cohort exists. Previously emergency sick day plans were not consistently in place and on national survey of 6 other Trusts, it was clear that advice and education for sick day steroid regimens was variable. <h3>Aim</h3> We sought to develop a weight-based steroid emergency regimen for DMD patients, many of whom are non-ambulant, and in whom accurate measurements for body surface area can be challenging. <h3>Methods</h3> A novel weight-based regimen of stress doses of oral hydrocortisone given 6 hourly was devised. This is to be implemented when needed, in addition to the glucocorticoid regimen the patient was taking for disease. <h3>Results</h3> Approval from the Drugs and Therapeutics committee was obtained for a novel weight-based stress dose regimen of hydrocortisone. Training and education were provided to increase awareness of adrenal insufficiency among patients and families. Families are educated about stress dosing plans, recognising signs/symptoms of adrenal crisis, and trained to give IM Hydrocortisone injections and provided with written information. Adrenal ‘Flags’ have been added to our electronic patient records alerting staff that these patients are at risk of adrenal crisis. <h3>Conclusion</h3> Anecdotally families report faster recovery times from illness since using stress-doses of hydrocortisone alongside their usual glucocorticoid. The development of a unified, consistent approach to illness management, alongside structured education for DMD patients and families, are initial actions towards improving clinical outcomes." @default.
• W4200213229 created "2021-12-31" @default.
• W4200213229 creator A5014280268 @default.
• W4200213229 creator A5018033470 @default.
• W4200213229 creator A5029068923 @default.
• W4200213229 creator A5041045608 @default.
• W4200213229 creator A5042607791 @default.
• W4200213229 creator A5053346671 @default.
• W4200213229 creator A5055601509 @default.
• W4200213229 creator A5063540517 @default.
• W4200213229 creator A5064729919 @default.
• W4200213229 creator A5068185368 @default.
• W4200213229 date "2021-12-01" @default.
• W4200213229 modified "2023-09-27" @default.
• W4200213229 title "29 Development of a novel weight-based steroid emergency plan for patients with Duchenne Muscular Dystrophy" @default.
• W4200213229 doi "https://doi.org/10.1136/archdischild-2021-gosh.29" @default.
• W4200213229 hasPublicationYear "2021" @default.
• W4200213229 type Work @default.
• W4200213229 citedByCount "0" @default.
• W4200213229 crossrefType "proceedings-article" @default.
• W4200213229 hasAuthorship W4200213229A5014280268 @default.
• W4200213229 hasAuthorship W4200213229A5018033470 @default.
• W4200213229 hasAuthorship W4200213229A5029068923 @default.
• W4200213229 hasAuthorship W4200213229A5041045608 @default.
• W4200213229 hasAuthorship W4200213229A5042607791 @default.
• W4200213229 hasAuthorship W4200213229A5053346671 @default.
• W4200213229 hasAuthorship W4200213229A5055601509 @default.
• W4200213229 hasAuthorship W4200213229A5063540517 @default.
• W4200213229 hasAuthorship W4200213229A5064729919 @default.
• W4200213229 hasAuthorship W4200213229A5068185368 @default.
• W4200213229 hasConcept C126322002 @default.
• W4200213229 hasConcept C1862650 @default.
• W4200213229 hasConcept C187212893 @default.
• W4200213229 hasConcept C2776715498 @default.
• W4200213229 hasConcept C2778129406 @default.
• W4200213229 hasConcept C2778709874 @default.
• W4200213229 hasConcept C2778720950 @default.
• W4200213229 hasConcept C2778808452 @default.
• W4200213229 hasConcept C2778943923 @default.
• W4200213229 hasConcept C2780841215 @default.
• W4200213229 hasConcept C2781413609 @default.
• W4200213229 hasConcept C71924100 @default.
• W4200213229 hasConceptScore W4200213229C126322002 @default.
• W4200213229 hasConceptScore W4200213229C1862650 @default.
• W4200213229 hasConceptScore W4200213229C187212893 @default.
• W4200213229 hasConceptScore W4200213229C2776715498 @default.
• W4200213229 hasConceptScore W4200213229C2778129406 @default.
• W4200213229 hasConceptScore W4200213229C2778709874 @default.
• W4200213229 hasConceptScore W4200213229C2778720950 @default.
• W4200213229 hasConceptScore W4200213229C2778808452 @default.
• W4200213229 hasConceptScore W4200213229C2778943923 @default.
• W4200213229 hasConceptScore W4200213229C2780841215 @default.
• W4200213229 hasConceptScore W4200213229C2781413609 @default.
• W4200213229 hasConceptScore W4200213229C71924100 @default.
• W4200213229 hasLocation W42002132291 @default.
• W4200213229 hasOpenAccess W4200213229 @default.
• W4200213229 hasPrimaryLocation W42002132291 @default.
• W4200213229 hasRelatedWork W10680619 @default.
• W4200213229 hasRelatedWork W11813810 @default.
• W4200213229 hasRelatedWork W13535411 @default.
• W4200213229 hasRelatedWork W13714650 @default.
• W4200213229 hasRelatedWork W13746830 @default.
• W4200213229 hasRelatedWork W17405363 @default.
• W4200213229 hasRelatedWork W286150 @default.
• W4200213229 hasRelatedWork W5598175 @default.
• W4200213229 hasRelatedWork W7724097 @default.
• W4200213229 hasRelatedWork W2682967 @default.
• W4200213229 isParatext "false" @default.
• W4200213229 isRetracted "false" @default.
• W4200213229 workType "article" @default.