Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200213586> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4200213586 abstract "Abstract Background: Oxidative stress is involved in pathogenesis of some psychiatric disorders. To examine the role of oxidative stress in the etiopathogenesis of obsessive-compulsive disorder (OCD), we aimed to determine oxidative stress indices, including MDA levels in serum and red blood cells (RBC) membrane, total antioxidant capacity (TAC), serum glutathione (GSH) levels, serum antioxidant vitamins (A and E) and Na + /K + -ATPase activity in patients with the mentioned disorder vs. healthy controls. Method: 39 OCD patients diagnosed based on Diagnostic and Statistical Manual of Mental Disorders (DSM-V), and 39 volunteers’ healthy subjects were included in this study. MDA levels in serum and RBC membrane were measured using fluorimetric method. Serum TAC level, serum GSH level and Na + /K + -ATPase activity were also measured using spectrophotometric methods. Serum levels of vitamins were calculated by Reversed-phase high-performance liquid chromatography (RP-HPLC). Result: There was a significantly higher MDA level in serum (p<0.0001) and RBC membrane (p=0.002) of OCD patients compared with those in controls. A significant reduction in vitamin A (p=0.024) and vitamin E (p=0.001) levels was found in OCD patients vs. controls. There was significantly lower activity of erythrocyte membrane Na + -K + ATPase in RBC membrane of OCD patients vs. controls (p<0.0001). Conclusion: Our findings indicate significantly higher levels MDA in both serum and RBC membrane, lower levels of serum vitamin A and E, and lower activity of membrane Na+-K+ ATPase in OCD patients compared to controls. These suggest an imbalance between oxidant and antioxidant factors in OCD patients that might play a fundamental role in the etiopathogenesis of OCD." @default.
- W4200213586 created "2021-12-31" @default.
- W4200213586 creator A5014470196 @default.
- W4200213586 creator A5029123125 @default.
- W4200213586 creator A5053784320 @default.
- W4200213586 creator A5057956040 @default.
- W4200213586 creator A5071546635 @default.
- W4200213586 creator A5087752277 @default.
- W4200213586 creator A5089568390 @default.
- W4200213586 date "2021-12-23" @default.
- W4200213586 modified "2023-10-11" @default.
- W4200213586 title "The Oxidative Status and Na +/K + -ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study" @default.
- W4200213586 doi "https://doi.org/10.21203/rs.3.rs-1158115/v1" @default.
- W4200213586 hasPublicationYear "2021" @default.
- W4200213586 type Work @default.
- W4200213586 citedByCount "2" @default.
- W4200213586 countsByYear W42002135862023 @default.
- W4200213586 crossrefType "posted-content" @default.
- W4200213586 hasAuthorship W4200213586A5014470196 @default.
- W4200213586 hasAuthorship W4200213586A5029123125 @default.
- W4200213586 hasAuthorship W4200213586A5053784320 @default.
- W4200213586 hasAuthorship W4200213586A5057956040 @default.
- W4200213586 hasAuthorship W4200213586A5071546635 @default.
- W4200213586 hasAuthorship W4200213586A5087752277 @default.
- W4200213586 hasAuthorship W4200213586A5089568390 @default.
- W4200213586 hasBestOaLocation W42002135861 @default.
- W4200213586 hasConcept C118552586 @default.
- W4200213586 hasConcept C126322002 @default.
- W4200213586 hasConcept C134018914 @default.
- W4200213586 hasConcept C181199279 @default.
- W4200213586 hasConcept C185592680 @default.
- W4200213586 hasConcept C2776151105 @default.
- W4200213586 hasConcept C2777551382 @default.
- W4200213586 hasConcept C2778004101 @default.
- W4200213586 hasConcept C2780022331 @default.
- W4200213586 hasConcept C3017582312 @default.
- W4200213586 hasConcept C538909803 @default.
- W4200213586 hasConcept C55493867 @default.
- W4200213586 hasConcept C71924100 @default.
- W4200213586 hasConceptScore W4200213586C118552586 @default.
- W4200213586 hasConceptScore W4200213586C126322002 @default.
- W4200213586 hasConceptScore W4200213586C134018914 @default.
- W4200213586 hasConceptScore W4200213586C181199279 @default.
- W4200213586 hasConceptScore W4200213586C185592680 @default.
- W4200213586 hasConceptScore W4200213586C2776151105 @default.
- W4200213586 hasConceptScore W4200213586C2777551382 @default.
- W4200213586 hasConceptScore W4200213586C2778004101 @default.
- W4200213586 hasConceptScore W4200213586C2780022331 @default.
- W4200213586 hasConceptScore W4200213586C3017582312 @default.
- W4200213586 hasConceptScore W4200213586C538909803 @default.
- W4200213586 hasConceptScore W4200213586C55493867 @default.
- W4200213586 hasConceptScore W4200213586C71924100 @default.
- W4200213586 hasLocation W42002135861 @default.
- W4200213586 hasOpenAccess W4200213586 @default.
- W4200213586 hasPrimaryLocation W42002135861 @default.
- W4200213586 hasRelatedWork W1985953997 @default.
- W4200213586 hasRelatedWork W2030227663 @default.
- W4200213586 hasRelatedWork W2056006053 @default.
- W4200213586 hasRelatedWork W2057720488 @default.
- W4200213586 hasRelatedWork W2154299504 @default.
- W4200213586 hasRelatedWork W2279320479 @default.
- W4200213586 hasRelatedWork W2365322489 @default.
- W4200213586 hasRelatedWork W3030144965 @default.
- W4200213586 hasRelatedWork W3042815394 @default.
- W4200213586 hasRelatedWork W4323046210 @default.
- W4200213586 isParatext "false" @default.
- W4200213586 isRetracted "false" @default.
- W4200213586 workType "article" @default.