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- W4200214201 abstract "Photoacoustic (PA) imaging has proved versatile for many biomedical applications from drug delivery tracking to disease diagnostics and postoperative surveillance. It recently emerged as a tool for accurate and real-time heparin monitoring to avoid bleeding complications associated with anticoagulant therapy. However, molecular-dye-based application is limited by high concentration requirements, photostability, and a strong background hemoglobin signal. We developed polydopamine nanocapsules (PNCs) via supramolecular templates and loaded them with molecular dyes for enhanced PA-mediated heparin detection. Depending on surface charge, the dye-loaded PNCs undergo disassembly or aggregation upon heparin recognition: both experiments and simulation have revealed that the increased PA signal mainly results from dye-loaded PNC–heparin aggregation. Importantly, Nile blue (NB)-loaded PNCs generated a 10-fold higher PA signal than free NB dye, and such PNC enabled the direct detection of heparin in a clinically relevant therapeutic window (0–4 U/mL) in whole human blood (R2 = 0.91). Furthermore, the PA signal of PNC@NB obtained from 17 patients linearly correlated with ACT values (R2 = 0.73) and cumulative heparin (R2 = 0.83). This PNC-based strategy for functional nanocapsules offers a versatile engineering platform for robust biomedical contrast agents and nanocarriers." @default.
- W4200214201 created "2021-12-31" @default.
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- W4200214201 date "2021-12-28" @default.
- W4200214201 modified "2023-10-15" @default.
- W4200214201 title "Enhanced Photoacoustic Detection of Heparin in Whole Blood <i>via</i> Melanin Nanocapsules Carrying Molecular Agents" @default.
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- W4200214201 doi "https://doi.org/10.1021/acsnano.1c08178" @default.
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