FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200214602> ?p ?o ?g. }

• W4200214602 endingPage "153738" @default.
• W4200214602 startingPage "153738" @default.
• W4200214602 abstract "Although several studies have evaluated PTEN loss in Prostatic Adenocarcinoma (PCa), PTEN loss correlation with different histological patterns only has a few studies. Although several studies have evaluated PD-L1 expression in PCa and its correlation with Gleason scores, as far as we know, there are no prior studies that have included a comparison between PD-L1 expression and histological patterns of PCa. This study aims to evaluate PTEN loss and PD-L1 expression by immunohistochemistry in different histological patterns of PCa.The current study included consecutive 98 radical prostatectomy specimens with 151 foci with different Gleason Grade (GG) patterns.The highest frequency of PTEN loss was observed in GG4 cribriform and glomeruloid patterns (59.3%, p < 0.001). Combined score (CS) PD-L1 positivity was observed in fourteen patients (14.2%). Tumor cell (TC) and tumor-associated inflammatory cells (IC) PD-L1 positivity was observed in 10 (10.2%) and 7 (7.1%) patients. The highest frequency of PD-L1 expression was observed in the GG5 pattern, and between GG4 patterns, the irregular pattern had the highest PD-L1 positivity.In conclusion, in our cohort of consecutive unselected cases of prostatic carcinoma, we observed the highest PTEN loss rate in the GG4 cribriform and glomeruloid pattern and the highest PD-L1 expression rate in the GG5 and GG4 irregular patterns. These results may predict molecular differences between different histological patterns in PCa and may be used to inform a treatment decision. Future studies should investigate these differences between histological patterns of PCa to predict response to immunotherapy in larger cohorts." @default.
• W4200214602 created "2021-12-31" @default.
• W4200214602 creator A5030455190 @default.
• W4200214602 creator A5039182070 @default.
• W4200214602 creator A5043733746 @default.
• W4200214602 creator A5049572962 @default.
• W4200214602 creator A5075541372 @default.
• W4200214602 date "2022-01-01" @default.
• W4200214602 modified "2023-10-18" @default.
• W4200214602 title "PTEN Loss and PD-L1 Expression of Different Histological Patterns of Prostate Cancer" @default.
• W4200214602 cites W1907505672 @default.
• W4200214602 cites W1966187746 @default.
• W4200214602 cites W1969553108 @default.
• W4200214602 cites W1996570931 @default.
• W4200214602 cites W2005841299 @default.
• W4200214602 cites W2009087111 @default.
• W4200214602 cites W2018756851 @default.
• W4200214602 cites W2038264173 @default.
• W4200214602 cites W2062254183 @default.
• W4200214602 cites W2087045997 @default.
• W4200214602 cites W2117050434 @default.
• W4200214602 cites W2138923955 @default.
• W4200214602 cites W2144601357 @default.
• W4200214602 cites W2148214708 @default.
• W4200214602 cites W2160714232 @default.
• W4200214602 cites W2160971263 @default.
• W4200214602 cites W2173477069 @default.
• W4200214602 cites W2180120860 @default.
• W4200214602 cites W2201788027 @default.
• W4200214602 cites W2331163623 @default.
• W4200214602 cites W2385742736 @default.
• W4200214602 cites W2406509798 @default.
• W4200214602 cites W2414848281 @default.
• W4200214602 cites W2467854262 @default.
• W4200214602 cites W2473794952 @default.
• W4200214602 cites W2474446109 @default.
• W4200214602 cites W2513592679 @default.
• W4200214602 cites W2520005590 @default.
• W4200214602 cites W2531934133 @default.
• W4200214602 cites W2545075008 @default.
• W4200214602 cites W2569362569 @default.
• W4200214602 cites W2591840592 @default.
• W4200214602 cites W2594102731 @default.
• W4200214602 cites W2602464207 @default.
• W4200214602 cites W2607084389 @default.
• W4200214602 cites W2612306984 @default.
• W4200214602 cites W2755595775 @default.
• W4200214602 cites W2772907685 @default.
• W4200214602 cites W2788783025 @default.
• W4200214602 cites W2791357477 @default.
• W4200214602 cites W2791483720 @default.
• W4200214602 cites W2806481527 @default.
• W4200214602 cites W2884883038 @default.
• W4200214602 cites W2945876244 @default.
• W4200214602 cites W2952835402 @default.
• W4200214602 cites W2955214500 @default.
• W4200214602 cites W2800942290 @default.
• W4200214602 doi "https://doi.org/10.1016/j.prp.2021.153738" @default.
• W4200214602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34922209" @default.
• W4200214602 hasPublicationYear "2022" @default.
• W4200214602 type Work @default.
• W4200214602 citedByCount "1" @default.
• W4200214602 crossrefType "journal-article" @default.
• W4200214602 hasAuthorship W4200214602A5030455190 @default.
• W4200214602 hasAuthorship W4200214602A5039182070 @default.
• W4200214602 hasAuthorship W4200214602A5043733746 @default.
• W4200214602 hasAuthorship W4200214602A5049572962 @default.
• W4200214602 hasAuthorship W4200214602A5075541372 @default.
• W4200214602 hasConcept C117220453 @default.
• W4200214602 hasConcept C121608353 @default.
• W4200214602 hasConcept C126322002 @default.
• W4200214602 hasConcept C142724271 @default.
• W4200214602 hasConcept C143998085 @default.
• W4200214602 hasConcept C190283241 @default.
• W4200214602 hasConcept C204232928 @default.
• W4200214602 hasConcept C2524010 @default.
• W4200214602 hasConcept C2776235491 @default.
• W4200214602 hasConcept C2777546739 @default.
• W4200214602 hasConcept C2777609662 @default.
• W4200214602 hasConcept C2779466945 @default.
• W4200214602 hasConcept C2780192828 @default.
• W4200214602 hasConcept C33923547 @default.
• W4200214602 hasConcept C55493867 @default.
• W4200214602 hasConcept C71924100 @default.
• W4200214602 hasConcept C86554907 @default.
• W4200214602 hasConcept C86803240 @default.
• W4200214602 hasConceptScore W4200214602C117220453 @default.
• W4200214602 hasConceptScore W4200214602C121608353 @default.
• W4200214602 hasConceptScore W4200214602C126322002 @default.
• W4200214602 hasConceptScore W4200214602C142724271 @default.
• W4200214602 hasConceptScore W4200214602C143998085 @default.
• W4200214602 hasConceptScore W4200214602C190283241 @default.
• W4200214602 hasConceptScore W4200214602C204232928 @default.
• W4200214602 hasConceptScore W4200214602C2524010 @default.
• W4200214602 hasConceptScore W4200214602C2776235491 @default.
• W4200214602 hasConceptScore W4200214602C2777546739 @default.
• W4200214602 hasConceptScore W4200214602C2777609662 @default.
• W4200214602 hasConceptScore W4200214602C2779466945 @default.

• next