FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200218345> ?p ?o ?g. }

• W4200218345 abstract "The SARS-CoV-2 B.1.1.529/Omicron variant was first characterized in South Africa and was swiftly designated a variant of concern 1 . Of great concern is its high number of mutations, including 30-40 mutations in the virus spike (S) protein compared to 7-10 for other variants. Some of these mutations have been shown to enhance escape from vaccine-induced immunity, while others remain uncharacterized. Additionally, reports of increasing frequencies of the Omicron variant may indicate a higher rate of transmission compared to other variants. However, the transmissibility of Omicron and its degree of resistance to vaccine-induced immunity remain unclear. Here we show that Omicron exhibits significant immune evasion compared to other variants, but antibody neutralization is largely restored by mRNA vaccine booster doses. Additionally, the Omicron spike exhibits reduced receptor binding, cell-cell fusion, S1 subunit shedding, but increased cell-to-cell transmission, and homology modeling indicates a more stable closed S structure. These findings suggest dual immune evasion strategies for Omicron, due to altered epitopes and reduced exposure of the S receptor binding domain, coupled with enhanced transmissibility due to enhanced S protein stability. These results highlight the importance of booster vaccine doses for maintaining protection against the Omicron variant, and provide mechanistic insight into the altered functionality of the Omicron spike protein." @default.
• W4200218345 created "2021-12-31" @default.
• W4200218345 creator A5003170920 @default.
• W4200218345 creator A5007786518 @default.
• W4200218345 creator A5018821266 @default.
• W4200218345 creator A5020807243 @default.
• W4200218345 creator A5034255344 @default.
• W4200218345 creator A5037620958 @default.
• W4200218345 creator A5039431143 @default.
• W4200218345 creator A5041285525 @default.
• W4200218345 creator A5042543645 @default.
• W4200218345 creator A5048118890 @default.
• W4200218345 creator A5057378730 @default.
• W4200218345 creator A5062868933 @default.
• W4200218345 creator A5064559752 @default.
• W4200218345 creator A5074278552 @default.
• W4200218345 creator A5076454649 @default.
• W4200218345 creator A5080767119 @default.
• W4200218345 date "2021-12-20" @default.
• W4200218345 modified "2023-10-13" @default.
• W4200218345 title "Neutralization and Stability of SARS-CoV-2 Omicron Variant" @default.
• W4200218345 cites W2034996626 @default.
• W4200218345 cites W2075864449 @default.
• W4200218345 cites W2081518077 @default.
• W4200218345 cites W3009912996 @default.
• W4200218345 cites W3084653951 @default.
• W4200218345 cites W3092477062 @default.
• W4200218345 cites W3093768302 @default.
• W4200218345 cites W3131995220 @default.
• W4200218345 cites W3138447431 @default.
• W4200218345 cites W3140446408 @default.
• W4200218345 cites W3163785571 @default.
• W4200218345 cites W3165441111 @default.
• W4200218345 cites W3165497143 @default.
• W4200218345 cites W3165803081 @default.
• W4200218345 cites W3194338378 @default.
• W4200218345 cites W3198233589 @default.
• W4200218345 cites W3200299601 @default.
• W4200218345 cites W3202368015 @default.
• W4200218345 cites W3212439952 @default.
• W4200218345 cites W3216196257 @default.
• W4200218345 cites W4200066927 @default.
• W4200218345 cites W4200253622 @default.
• W4200218345 cites W4200469371 @default.
• W4200218345 cites W4200553651 @default.
• W4200218345 cites W4206481051 @default.
• W4200218345 doi "https://doi.org/10.1101/2021.12.16.472934" @default.
• W4200218345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34981053" @default.
• W4200218345 hasPublicationYear "2021" @default.
• W4200218345 type Work @default.
• W4200218345 citedByCount "57" @default.
• W4200218345 countsByYear W42002183452021 @default.
• W4200218345 countsByYear W42002183452022 @default.
• W4200218345 countsByYear W42002183452023 @default.
• W4200218345 crossrefType "posted-content" @default.
• W4200218345 hasAuthorship W4200218345A5003170920 @default.
• W4200218345 hasAuthorship W4200218345A5007786518 @default.
• W4200218345 hasAuthorship W4200218345A5018821266 @default.
• W4200218345 hasAuthorship W4200218345A5020807243 @default.
• W4200218345 hasAuthorship W4200218345A5034255344 @default.
• W4200218345 hasAuthorship W4200218345A5037620958 @default.
• W4200218345 hasAuthorship W4200218345A5039431143 @default.
• W4200218345 hasAuthorship W4200218345A5041285525 @default.
• W4200218345 hasAuthorship W4200218345A5042543645 @default.
• W4200218345 hasAuthorship W4200218345A5048118890 @default.
• W4200218345 hasAuthorship W4200218345A5057378730 @default.
• W4200218345 hasAuthorship W4200218345A5062868933 @default.
• W4200218345 hasAuthorship W4200218345A5064559752 @default.
• W4200218345 hasAuthorship W4200218345A5074278552 @default.
• W4200218345 hasAuthorship W4200218345A5076454649 @default.
• W4200218345 hasAuthorship W4200218345A5080767119 @default.
• W4200218345 hasBestOaLocation W42002183451 @default.
• W4200218345 hasConcept C104292427 @default.
• W4200218345 hasConcept C104317684 @default.
• W4200218345 hasConcept C121332964 @default.
• W4200218345 hasConcept C14086860 @default.
• W4200218345 hasConcept C159047783 @default.
• W4200218345 hasConcept C159654299 @default.
• W4200218345 hasConcept C16683452 @default.
• W4200218345 hasConcept C198394728 @default.
• W4200218345 hasConcept C2522874641 @default.
• W4200218345 hasConcept C2779341262 @default.
• W4200218345 hasConcept C45799244 @default.
• W4200218345 hasConcept C54355233 @default.
• W4200218345 hasConcept C62520636 @default.
• W4200218345 hasConcept C86803240 @default.
• W4200218345 hasConcept C8891405 @default.
• W4200218345 hasConceptScore W4200218345C104292427 @default.
• W4200218345 hasConceptScore W4200218345C104317684 @default.
• W4200218345 hasConceptScore W4200218345C121332964 @default.
• W4200218345 hasConceptScore W4200218345C14086860 @default.
• W4200218345 hasConceptScore W4200218345C159047783 @default.
• W4200218345 hasConceptScore W4200218345C159654299 @default.
• W4200218345 hasConceptScore W4200218345C16683452 @default.
• W4200218345 hasConceptScore W4200218345C198394728 @default.
• W4200218345 hasConceptScore W4200218345C2522874641 @default.
• W4200218345 hasConceptScore W4200218345C2779341262 @default.
• W4200218345 hasConceptScore W4200218345C45799244 @default.
• W4200218345 hasConceptScore W4200218345C54355233 @default.
• W4200218345 hasConceptScore W4200218345C62520636 @default.

• next