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- W4200219776 endingPage "103569" @default.
- W4200219776 startingPage "103569" @default.
- W4200219776 abstract "Hepatitis C virus (HCV) is a leading cause of liver-associated disease and liver cancer. Of the major HCV subtypes, patients infected with subtype 1b have been associated with having a higher risk of developing chronic infection and hepatocellular carcinoma. However, underlying reasons for this increased disease severity remain unknown. Here, we provide an evolutionary rationale, based on a comparative study of fitness landscape and in-host evolutionary models of the E2 glycoprotein of HCV subtypes 1a and 1b. Our analysis demonstrates that a higher chronicity rate of 1b may be attributed to lower fitness constraints, enabling 1b viruses to more easily escape antibody responses. More generally, our results suggest that differences in evolutionary constraints between HCV subtypes may be an important factor in mediating distinct disease outcomes. Our analysis also identifies antibodies that appear escape-resistant against both subtypes 1a and 1b, providing directions for designing HCV vaccines having cross-subtype protection." @default.
- W4200219776 created "2021-12-31" @default.
- W4200219776 creator A5004347609 @default.
- W4200219776 creator A5069725534 @default.
- W4200219776 creator A5091126453 @default.
- W4200219776 date "2022-01-01" @default.
- W4200219776 modified "2023-10-14" @default.
- W4200219776 title "Evolutionary modeling reveals enhanced mutational flexibility of HCV subtype 1b compared with 1a" @default.
- W4200219776 cites W1578834103 @default.
- W4200219776 cites W1592244475 @default.
- W4200219776 cites W1912933662 @default.
- W4200219776 cites W1967491261 @default.
- W4200219776 cites W1974464383 @default.
- W4200219776 cites W1979256639 @default.
- W4200219776 cites W1979762151 @default.
- W4200219776 cites W1982494640 @default.
- W4200219776 cites W2003914177 @default.
- W4200219776 cites W2004372194 @default.
- W4200219776 cites W2008545402 @default.
- W4200219776 cites W2017052897 @default.
- W4200219776 cites W2018853124 @default.
- W4200219776 cites W2040975718 @default.
- W4200219776 cites W2042063943 @default.
- W4200219776 cites W2053763835 @default.
- W4200219776 cites W2063166286 @default.
- W4200219776 cites W2064778609 @default.
- W4200219776 cites W2067427769 @default.
- W4200219776 cites W2068265376 @default.
- W4200219776 cites W2073765811 @default.
- W4200219776 cites W2074139927 @default.
- W4200219776 cites W2074385376 @default.
- W4200219776 cites W2085600385 @default.
- W4200219776 cites W2092572492 @default.
- W4200219776 cites W2094193440 @default.
- W4200219776 cites W2095641332 @default.
- W4200219776 cites W2104010560 @default.
- W4200219776 cites W2108823152 @default.
- W4200219776 cites W2111243299 @default.
- W4200219776 cites W2115645840 @default.
- W4200219776 cites W2117105620 @default.
- W4200219776 cites W2119428549 @default.
- W4200219776 cites W2122228848 @default.
- W4200219776 cites W2127272751 @default.
- W4200219776 cites W2129327996 @default.
- W4200219776 cites W2130710252 @default.
- W4200219776 cites W2133036275 @default.
- W4200219776 cites W2135773419 @default.
- W4200219776 cites W2137566700 @default.
- W4200219776 cites W2140406478 @default.
- W4200219776 cites W2142808579 @default.
- W4200219776 cites W2144743578 @default.
- W4200219776 cites W2145605402 @default.
- W4200219776 cites W2146287483 @default.
- W4200219776 cites W2146891463 @default.
- W4200219776 cites W2148541719 @default.
- W4200219776 cites W2153130425 @default.
- W4200219776 cites W2154624072 @default.
- W4200219776 cites W2155574487 @default.
- W4200219776 cites W2160179097 @default.
- W4200219776 cites W2165796431 @default.
- W4200219776 cites W2169610187 @default.
- W4200219776 cites W2172376015 @default.
- W4200219776 cites W2218122840 @default.
- W4200219776 cites W2229041149 @default.
- W4200219776 cites W2325791202 @default.
- W4200219776 cites W2344591610 @default.
- W4200219776 cites W2402027820 @default.
- W4200219776 cites W2470723632 @default.
- W4200219776 cites W2517875316 @default.
- W4200219776 cites W2534638877 @default.
- W4200219776 cites W2535014449 @default.
- W4200219776 cites W2545259858 @default.
- W4200219776 cites W2604003697 @default.
- W4200219776 cites W2606295382 @default.
- W4200219776 cites W2611776159 @default.
- W4200219776 cites W2737510383 @default.
- W4200219776 cites W2780150340 @default.
- W4200219776 cites W2783515291 @default.
- W4200219776 cites W2798874307 @default.
- W4200219776 cites W2809309190 @default.
- W4200219776 cites W2888122510 @default.
- W4200219776 cites W2894067555 @default.
- W4200219776 cites W2898389621 @default.
- W4200219776 cites W2900738171 @default.
- W4200219776 cites W2916422396 @default.
- W4200219776 cites W2932718018 @default.
- W4200219776 cites W2943267083 @default.
- W4200219776 cites W2943694132 @default.
- W4200219776 cites W2944971982 @default.
- W4200219776 cites W2953157285 @default.
- W4200219776 cites W2955736552 @default.
- W4200219776 cites W2995264458 @default.
- W4200219776 cites W2999957331 @default.
- W4200219776 cites W3011007866 @default.
- W4200219776 cites W3034852671 @default.
- W4200219776 cites W3108800484 @default.
- W4200219776 cites W3124930795 @default.
- W4200219776 doi "https://doi.org/10.1016/j.isci.2021.103569" @default.