Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200220474> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4200220474 abstract "Abstract Purpose This study aimed to compare the diagnostic performance of [ 68 Ga]Ga-DOTA-FAPI-04 and [ 18 F]-FDG PET/CT in the primary and metastatic lesions of gastric cancer. Methods Fifty-six patients with histologically proven gastric carcinomas were enrolled in this study. Each patient underwent both [ 18 F]-FDG and [ 68 Ga]Ga-FAPI-04 PET/CT within one week. Activity of tracer accumulation in lesions were assessed by maximum standardized uptake value (SUV max ) and TBR (lesions SUV max / ascending aorta SUV mean ). Histological work-up including immunohistochemical staining for FAP served as a standard of reference. Results [ 68 Ga]Ga-FAPI PET/CT is superior in detecting primary tumors both in patient-based (100% [45/45] vs. 97.8% [44/45]) and lesion-based analyses (97.8% [45/46] vs. 95.7% [44/46]), showing higher SUV max (10.25 vs. 8.13, P = 0.004) and TBR (11.63 vs. 5.83, P < 0.001), compared with [ 18 F]-FDG PET/CT. The specificity and positive predictive value of [ 68 Ga]Ga-FAPI were significantly higher than that of [ 18 F]-FDG (100.0% vs. 97.7%, P < 0.001; 100.0% vs. 57.1%, P = 0.001) in determining the lymph node (LN) metastases. [ 68 Ga]Ga-FAPI PET/CT was superior to [ 18 F]-FDG PET/CT in N-staging (47.1% [8/17] vs. 23.5% [4/17]), and in evaluation for LN, peritoneum and bone metastases. [ 68 Ga]Ga-FAPI PET/CT detected positive recurrent lesions in all patients and showed more positive lesions and clearer tumor delineation. Two patients underwent follow-up [ 68 Ga]Ga-FAPI PET/CT scans after chemotherapy, which both showed remission. Conclusions [ 68 Ga]Ga-FAPI PET/CT can better detect primary gastric cancer and metastatic lesions in peritoneum, abdominal LNs and bone, showing high usefulness in guiding N staging. Furthermore, [ 68 Ga]Ga-FAPI PET/CT provides more information for patients with recurrence detection and also has great potential in monitoring response to treatment." @default.
- W4200220474 created "2021-12-31" @default.
- W4200220474 creator A5000854172 @default.
- W4200220474 creator A5005329668 @default.
- W4200220474 creator A5027334447 @default.
- W4200220474 creator A5038779416 @default.
- W4200220474 creator A5064871335 @default.
- W4200220474 creator A5065900457 @default.
- W4200220474 creator A5083265775 @default.
- W4200220474 date "2021-12-15" @default.
- W4200220474 modified "2023-10-14" @default.
- W4200220474 title "[68Ga]Ga-DOTA-FAPI-04 PET/CT in The Staging of Gastric Cancer: Improved Diagnostic Efficacy Confirmed By Postoperative Histopathology" @default.
- W4200220474 doi "https://doi.org/10.21203/rs.3.rs-1142541/v1" @default.
- W4200220474 hasPublicationYear "2021" @default.
- W4200220474 type Work @default.
- W4200220474 citedByCount "0" @default.
- W4200220474 crossrefType "posted-content" @default.
- W4200220474 hasAuthorship W4200220474A5000854172 @default.
- W4200220474 hasAuthorship W4200220474A5005329668 @default.
- W4200220474 hasAuthorship W4200220474A5027334447 @default.
- W4200220474 hasAuthorship W4200220474A5038779416 @default.
- W4200220474 hasAuthorship W4200220474A5064871335 @default.
- W4200220474 hasAuthorship W4200220474A5065900457 @default.
- W4200220474 hasAuthorship W4200220474A5083265775 @default.
- W4200220474 hasBestOaLocation W42002204741 @default.
- W4200220474 hasConcept C121608353 @default.
- W4200220474 hasConcept C126322002 @default.
- W4200220474 hasConcept C127077266 @default.
- W4200220474 hasConcept C142724271 @default.
- W4200220474 hasConcept C150903083 @default.
- W4200220474 hasConcept C199374082 @default.
- W4200220474 hasConcept C207001950 @default.
- W4200220474 hasConcept C2775842073 @default.
- W4200220474 hasConcept C2779931791 @default.
- W4200220474 hasConcept C2780849966 @default.
- W4200220474 hasConcept C2989005 @default.
- W4200220474 hasConcept C544855455 @default.
- W4200220474 hasConcept C71924100 @default.
- W4200220474 hasConcept C86803240 @default.
- W4200220474 hasConceptScore W4200220474C121608353 @default.
- W4200220474 hasConceptScore W4200220474C126322002 @default.
- W4200220474 hasConceptScore W4200220474C127077266 @default.
- W4200220474 hasConceptScore W4200220474C142724271 @default.
- W4200220474 hasConceptScore W4200220474C150903083 @default.
- W4200220474 hasConceptScore W4200220474C199374082 @default.
- W4200220474 hasConceptScore W4200220474C207001950 @default.
- W4200220474 hasConceptScore W4200220474C2775842073 @default.
- W4200220474 hasConceptScore W4200220474C2779931791 @default.
- W4200220474 hasConceptScore W4200220474C2780849966 @default.
- W4200220474 hasConceptScore W4200220474C2989005 @default.
- W4200220474 hasConceptScore W4200220474C544855455 @default.
- W4200220474 hasConceptScore W4200220474C71924100 @default.
- W4200220474 hasConceptScore W4200220474C86803240 @default.
- W4200220474 hasLocation W42002204741 @default.
- W4200220474 hasOpenAccess W4200220474 @default.
- W4200220474 hasPrimaryLocation W42002204741 @default.
- W4200220474 hasRelatedWork W1964235690 @default.
- W4200220474 hasRelatedWork W2069054254 @default.
- W4200220474 hasRelatedWork W2070705913 @default.
- W4200220474 hasRelatedWork W2138033649 @default.
- W4200220474 hasRelatedWork W2159865368 @default.
- W4200220474 hasRelatedWork W2183007308 @default.
- W4200220474 hasRelatedWork W2909852936 @default.
- W4200220474 hasRelatedWork W2951337402 @default.
- W4200220474 hasRelatedWork W3146608639 @default.
- W4200220474 hasRelatedWork W4238492639 @default.
- W4200220474 isParatext "false" @default.
- W4200220474 isRetracted "false" @default.
- W4200220474 workType "article" @default.