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- W4200220573 abstract "Abstract The bacterial cell wall supports cell shape and prevents lysis due to internal turgor pressure. A primary component of all known bacterial cell walls is the peptidoglycan (PG) layer, which is comprised of repeating units of sugars connected to short and unusual peptides. The various steps within PG biosynthesis are often the target of antibiotics as they are essential for cellular growth and survival. Synthetic mimics of PG have proven to be indispensable tools to study bacterial cell growth and remodeling. Yet, a common component of PG, meso -diaminopimelic acid ( m -DAP) at the third position of the stem peptide, remains challenging to build synthetically and is not commercially available. Here, we describe the synthesis and metabolic processing of a selenium-based bioisostere of a m -DAP analogue, selenolanthionine. We show that selenolanthionine is installed within the PG of live bacteria by the native cell wall crosslinking machinery in several mycobacteria species. We envision that this probe will supplement the current methods available for investigating PG crosslinking in m -DAP containing organisms." @default.
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- W4200220573 date "2021-12-19" @default.
- W4200220573 modified "2023-10-17" @default.
- W4200220573 title "Metabolic Processing of Selenium-based Bioisostere of <i>meso</i>-diaminopimelic Acid in Live Bacteria" @default.
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- W4200220573 doi "https://doi.org/10.1101/2021.12.18.472960" @default.
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