FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200221799> ?p ?o ?g. }

• W4200221799 abstract "Detailed characterization of medullary and extramedullary reservoirs of osteoclast progenitors (OCPs) is required to understand the pathophysiology of increased periarticular and systemic bone resorption in arthritis. In this study, we focused on identifying the OCP population specifically induced by arthritis and the role of circulatory OCPs in inflammatory bone loss. In addition, we determined the relevant chemokine axis responsible for their migration, and targeted the attraction signal to reduce bone resorption in murine collagen-induced arthritis (CIA). OCPs were expanded in periarticular as well as circulatory compartment of arthritic mice, particularly the CCR2hi subset. This subset demonstrated enhanced osteoclastogenic activity in arthritis, whereas its migratory potential was susceptible to CCR2 blockade in vitro. Intravascular compartment of the periarticular area contained increased frequency of OCPs with the ability to home to the arthritic bone, as demonstrated in vivo by intravascular staining and adoptive transfer of splenic LysMcre/Ai9 tdTomato-expressing cells. Simultaneously, CCL2 levels were increased locally and systemically in arthritic mice. Mouse cohorts were treated with the small-molecule inhibitor (SMI) of CCR2 alone or in combination with methotrexate (MTX). Preventive CCR2/CCL2 axis blockade in vivo reduced bone resorption and OCP frequency, whereas combining with MTX treatment also decreased disease clinical score, number of active osteoclasts, and OCP differentiation potential. In conclusion, our study characterized the functional properties of two distinct OCP subsets in CIA, based on their CCR2 expression levels, implying that the CCR2hi circulatory-like subset is specifically induced by arthritis. Signaling through the CCL2/CCR2 axis contributes to OCP homing in the inflamed joints and to their increased osteoclastogenic potential. Therefore, addition of CCL2/CCR2 blockade early in the course of arthritis is a promising approach to reduce bone pathology." @default.
• W4200221799 created "2021-12-31" @default.
• W4200221799 creator A5003761640 @default.
• W4200221799 creator A5008013035 @default.
• W4200221799 creator A5026351099 @default.
• W4200221799 creator A5036314365 @default.
• W4200221799 creator A5054122738 @default.
• W4200221799 creator A5057738740 @default.
• W4200221799 creator A5059880185 @default.
• W4200221799 creator A5062454028 @default.
• W4200221799 creator A5064129016 @default.
• W4200221799 creator A5069860520 @default.
• W4200221799 creator A5076199878 @default.
• W4200221799 creator A5091730315 @default.
• W4200221799 date "2021-12-03" @default.
• W4200221799 modified "2023-10-16" @default.
• W4200221799 title "Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2hi Osteoclast Progenitors to the Affected Bone" @default.
• W4200221799 cites W1595293335 @default.
• W4200221799 cites W1657484783 @default.
• W4200221799 cites W1672365393 @default.
• W4200221799 cites W1966242724 @default.
• W4200221799 cites W1967502057 @default.
• W4200221799 cites W1969720186 @default.
• W4200221799 cites W1969905657 @default.
• W4200221799 cites W1979935756 @default.
• W4200221799 cites W1983134858 @default.
• W4200221799 cites W2000077738 @default.
• W4200221799 cites W2002584410 @default.
• W4200221799 cites W2002861386 @default.
• W4200221799 cites W2003336545 @default.
• W4200221799 cites W2010190600 @default.
• W4200221799 cites W2011909999 @default.
• W4200221799 cites W2012059967 @default.
• W4200221799 cites W2016619112 @default.
• W4200221799 cites W2026578487 @default.
• W4200221799 cites W2037123168 @default.
• W4200221799 cites W2044684335 @default.
• W4200221799 cites W2046877737 @default.
• W4200221799 cites W2049069390 @default.
• W4200221799 cites W2058189238 @default.
• W4200221799 cites W2070871300 @default.
• W4200221799 cites W2075390633 @default.
• W4200221799 cites W2085099489 @default.
• W4200221799 cites W2090655549 @default.
• W4200221799 cites W2099253276 @default.
• W4200221799 cites W2099989406 @default.
• W4200221799 cites W2101939713 @default.
• W4200221799 cites W2101980834 @default.
• W4200221799 cites W2107540216 @default.
• W4200221799 cites W2109648873 @default.
• W4200221799 cites W2116727386 @default.
• W4200221799 cites W2127909824 @default.
• W4200221799 cites W2128952811 @default.
• W4200221799 cites W2132162170 @default.
• W4200221799 cites W2140612433 @default.
• W4200221799 cites W2146607274 @default.
• W4200221799 cites W2149210314 @default.
• W4200221799 cites W2153095884 @default.
• W4200221799 cites W2157881954 @default.
• W4200221799 cites W2162184586 @default.
• W4200221799 cites W2164423257 @default.
• W4200221799 cites W2518957594 @default.
• W4200221799 cites W2539871382 @default.
• W4200221799 cites W2625551683 @default.
• W4200221799 cites W2811106513 @default.
• W4200221799 cites W2887885773 @default.
• W4200221799 cites W2897987571 @default.
• W4200221799 cites W2901831700 @default.
• W4200221799 cites W2936121316 @default.
• W4200221799 cites W2954541576 @default.
• W4200221799 cites W2970121222 @default.
• W4200221799 cites W2973533641 @default.
• W4200221799 cites W2995755986 @default.
• W4200221799 cites W2996843935 @default.
• W4200221799 cites W2999400492 @default.
• W4200221799 cites W3003464185 @default.
• W4200221799 cites W3096691157 @default.
• W4200221799 cites W3097084299 @default.
• W4200221799 cites W3118335636 @default.
• W4200221799 cites W3118934078 @default.
• W4200221799 cites W3128337426 @default.
• W4200221799 cites W4211054359 @default.
• W4200221799 cites W4296816736 @default.
• W4200221799 doi "https://doi.org/10.3389/fimmu.2021.767231" @default.
• W4200221799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34925336" @default.
• W4200221799 hasPublicationYear "2021" @default.
• W4200221799 type Work @default.
• W4200221799 citedByCount "6" @default.
• W4200221799 countsByYear W42002217992022 @default.
• W4200221799 countsByYear W42002217992023 @default.
• W4200221799 crossrefType "journal-article" @default.
• W4200221799 hasAuthorship W4200221799A5003761640 @default.
• W4200221799 hasAuthorship W4200221799A5008013035 @default.
• W4200221799 hasAuthorship W4200221799A5026351099 @default.
• W4200221799 hasAuthorship W4200221799A5036314365 @default.
• W4200221799 hasAuthorship W4200221799A5054122738 @default.
• W4200221799 hasAuthorship W4200221799A5057738740 @default.
• W4200221799 hasAuthorship W4200221799A5059880185 @default.
• W4200221799 hasAuthorship W4200221799A5062454028 @default.
• W4200221799 hasAuthorship W4200221799A5064129016 @default.

• next