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- W4200224154 abstract "Cysteine (Cys), the only amino acid in the 20 natural amino acids that contains a reduced sulfhydryl group, plays important roles in the balance of redox homeostasis in biological systems. Lysosome is an important organelle containing a variety of hydrolases and has been proved to be the decomposition center of a variety of exogenous and endogenous macromolecular substances. In this research, a coumarin-based fluorescent probe MCA for the detection of Cys in lysosomes of living cells was developed. Due to the acrylate moiety, this probe exhibited high sensitivity (detection limit = 6.8 nM) and selectivity towards Cys superior to other analytes. Moreover, the probe was proved to be lysosome-targetable and showed good cell imaging ability and low cell toxicity." @default.
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- W4200224154 date "2022-02-01" @default.
- W4200224154 modified "2023-10-16" @default.
- W4200224154 title "A coumarin-based fluorescent probe for specific detection of cysteine in the lysosome of living cells" @default.
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- W4200224154 doi "https://doi.org/10.1016/j.bioorg.2021.105558" @default.
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