Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200224920> ?p ?o ?g. }
- W4200224920 endingPage "3622" @default.
- W4200224920 startingPage "3611" @default.
- W4200224920 abstract "Structural neuroimaging studies of individuals with chronic pain conditions have often observed decreased regional grey matter at a phenotypic level. However, it is not known if this association can be attributed to genetic factors. Here we employed a novel integrative data-driven and hypothesis-testing approach to determine whether there is a genetic basis to grey matter morphology differences in chronic pain. Using publicly available genome-wide association study summary statistics for regional chronic pain conditions (n = 196 963) and structural neuroimaging measures (n = 19 629-34 000), we applied bivariate linkage disequilibrium-score regression and latent causal variable analyses to determine the genetic correlations (rG) and genetic causal proportion (GCP) between these complex traits, respectively. Five a priori brain regions (i.e. prefrontal cortex, cingulate cortex, insula, thalamus and superior temporal gyrus) were selected based on systematic reviews of grey matter morphology studies in chronic pain. Across this evidence-based selection of five brain regions, 10 significant negative genetic correlations (out of 369) were found (false discovery rate < 5%), suggesting a shared genetic basis to both reduced regional grey matter morphology and the presence of chronic pain. Specifically, negative genetic correlations were observed between reduced insula grey matter morphology and chronic pain in the abdomen (mean insula cortical thickness), hips (left insula volume) and neck/shoulders (left and right insula volume). Similarly, a shared genetic basis was found for reduced posterior cingulate cortex volume in chronic pain of the hip (left and right posterior cingulate), neck/shoulder (left posterior cingulate) and chronic pain at any site (left posterior cingulate); and for reduced pars triangularis volume in chronic neck/shoulder (left pars triangularis) and widespread pain (right pars triangularis). Across these negative genetic correlations, a significant genetic causal proportion was only found between mean insula thickness and chronic abdominal pain [rG (standard error, SE) = -0.25 (0.08), P = 1.06 × 10-3; GCP (SE) = -0.69 (0.20), P = 4.96 × 10-4]. This finding suggests that the genes underlying reduced cortical thickness of the insula causally contribute to an increased risk of chronic abdominal pain. Altogether, these results provide independent corroborating evidence for observational reports of decreased grey matter of particular brain regions in chronic pain. Further, we show for the first time that this association is mediated (in part) by genetic factors. These novel findings warrant further investigation into the neurogenetic pathways that underlie the development and prolongation of chronic pain conditions." @default.
- W4200224920 created "2021-12-31" @default.
- W4200224920 creator A5007014621 @default.
- W4200224920 creator A5010775510 @default.
- W4200224920 creator A5018398870 @default.
- W4200224920 creator A5023858461 @default.
- W4200224920 creator A5038796650 @default.
- W4200224920 creator A5049311670 @default.
- W4200224920 creator A5066568424 @default.
- W4200224920 creator A5074757064 @default.
- W4200224920 date "2021-12-01" @default.
- W4200224920 modified "2023-10-02" @default.
- W4200224920 title "Genetic basis to structural grey matter associations with chronic pain" @default.
- W4200224920 cites W1531443818 @default.
- W4200224920 cites W1871257674 @default.
- W4200224920 cites W1972958276 @default.
- W4200224920 cites W1976766380 @default.
- W4200224920 cites W2003564359 @default.
- W4200224920 cites W2010535784 @default.
- W4200224920 cites W2017404787 @default.
- W4200224920 cites W2019587683 @default.
- W4200224920 cites W2029985169 @default.
- W4200224920 cites W2043676066 @default.
- W4200224920 cites W2093860430 @default.
- W4200224920 cites W2094161619 @default.
- W4200224920 cites W2109824984 @default.
- W4200224920 cites W2114969507 @default.
- W4200224920 cites W2121531670 @default.
- W4200224920 cites W2139313102 @default.
- W4200224920 cites W2140054173 @default.
- W4200224920 cites W2149421654 @default.
- W4200224920 cites W2159936035 @default.
- W4200224920 cites W2159936922 @default.
- W4200224920 cites W2162638563 @default.
- W4200224920 cites W2195783463 @default.
- W4200224920 cites W2203834106 @default.
- W4200224920 cites W2254287137 @default.
- W4200224920 cites W2409370130 @default.
- W4200224920 cites W2411898078 @default.
- W4200224920 cites W2462596148 @default.
- W4200224920 cites W2508825314 @default.
- W4200224920 cites W2510547160 @default.
- W4200224920 cites W2520048741 @default.
- W4200224920 cites W2522628945 @default.
- W4200224920 cites W2565169962 @default.
- W4200224920 cites W2565199748 @default.
- W4200224920 cites W2579322749 @default.
- W4200224920 cites W2589485640 @default.
- W4200224920 cites W2589669225 @default.
- W4200224920 cites W2592061714 @default.
- W4200224920 cites W2616271545 @default.
- W4200224920 cites W2738244454 @default.
- W4200224920 cites W2740710178 @default.
- W4200224920 cites W2740717214 @default.
- W4200224920 cites W2753835647 @default.
- W4200224920 cites W2782556780 @default.
- W4200224920 cites W2787914077 @default.
- W4200224920 cites W2791797536 @default.
- W4200224920 cites W2793659156 @default.
- W4200224920 cites W2887074661 @default.
- W4200224920 cites W2900559304 @default.
- W4200224920 cites W2901740549 @default.
- W4200224920 cites W2905788968 @default.
- W4200224920 cites W2911128047 @default.
- W4200224920 cites W2913254245 @default.
- W4200224920 cites W2920676517 @default.
- W4200224920 cites W2921028723 @default.
- W4200224920 cites W2921660871 @default.
- W4200224920 cites W2921726292 @default.
- W4200224920 cites W2948487606 @default.
- W4200224920 cites W2949838037 @default.
- W4200224920 cites W2950086191 @default.
- W4200224920 cites W2950439954 @default.
- W4200224920 cites W2950958620 @default.
- W4200224920 cites W2953297691 @default.
- W4200224920 cites W2967998970 @default.
- W4200224920 cites W2969537933 @default.
- W4200224920 cites W2970281210 @default.
- W4200224920 cites W2980165972 @default.
- W4200224920 cites W2980845649 @default.
- W4200224920 cites W2980879969 @default.
- W4200224920 cites W2981563631 @default.
- W4200224920 cites W2982163969 @default.
- W4200224920 cites W2982417329 @default.
- W4200224920 cites W2985923507 @default.
- W4200224920 cites W2986919234 @default.
- W4200224920 cites W2990248510 @default.
- W4200224920 cites W2991931424 @default.
- W4200224920 cites W3000068311 @default.
- W4200224920 cites W3011154449 @default.
- W4200224920 cites W3012009865 @default.
- W4200224920 cites W3014536739 @default.
- W4200224920 cites W3021472336 @default.
- W4200224920 cites W3021895952 @default.
- W4200224920 cites W3029092466 @default.
- W4200224920 cites W3035623431 @default.
- W4200224920 cites W3036410631 @default.
- W4200224920 cites W3037707799 @default.