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- W4200227574 abstract "To investigate whether adverse maternal or neonatal outcomes are associated with an isolated abnormal 1-hour glucose challenge test (GCT) among women without gestational diabetes (GDM). This is a retrospective cohort study of women who underwent third trimester GDM screening with a 1-hour GCT and delivered a singleton, non-anomalous fetus at >35 weeks’ gestation at a tertiary hospital 1/2013-4/2021. Data were extracted from an electronic medical record data warehouse using standardized definitions and billing/diagnosis codes. Women were categorized based upon the results of GCT screening as follows: normal 1-hour, abnormal 1-hour ( >=135) but normal 3-hour, and GDM (1-hour GCT >200 or abnormal 3-hour GTT). The primary composite perinatal morbidity outcome included large for gestational age (LGA) birthweight, birth injury, hypoglycemia, respiratory distress syndrome, transient tachypnea of newborn, apnea, NICU admission, or perinatal death. Secondary outcomes included cesarean delivery, OASIS injury, hypertensive disorders of pregnancy (HDP), and small for gestational age (SGA) birthweight. Bivariable and multivariable analyses were performed. Of 28,263 eligible women, 22,693 (80.3%) had normal screening, 5086 (18%) had an abnormal 1-hour but normal 3-hour GCT, and 484 (1.7%) had GDM. There were significant differences in baseline characteristics between groups (Table 1). Compared to normal screening, an isolated abnormal 1-hour GCT was associated with an increased risk for the composite perinatal morbidity outcome, cesarean, and HDP. These associations were similarly seen and further elevated, in addition to OASIS injury, in those with GDM diagnosis. These significant associations persist after adjusting for potential confounders (Table 2). Women with an isolated abnormal 1-hour GCT and GDM diagnosis experienced increased risks for adverse pregnancy outcomes, portraying an exposure-response relationship. Maternal glucose dysregulation in pregnancy likely occurs on a continuum. Those with mild dysregulation may still benefit from counseling and other interventions.View Large Image Figure ViewerDownload Hi-res image Download (PPT)" @default.
- W4200227574 created "2021-12-31" @default.
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- W4200227574 date "2022-01-01" @default.
- W4200227574 modified "2023-09-26" @default.
- W4200227574 title "Is an isolated abnormal 1-hour glucose challenge test associated with adverse pregnancy outcomes?" @default.
- W4200227574 doi "https://doi.org/10.1016/j.ajog.2021.11.262" @default.
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