FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200232366> ?p ?o ?g. }

• W4200232366 abstract "The interaction of signal regulatory protein α (SIRPα) on macrophages with CD47 on cancer cells is thought to prevent antibody (Ab)-dependent cellular phagocytosis (ADCP) of the latter cells by the former. Blockade of the CD47-SIRPα interaction by Abs to CD47 or to SIRPα, in combination with tumor-targeting Abs such as rituximab, thus inhibits tumor formation by promoting macrophage-mediated ADCP of cancer cells. Here we show that monotherapy with a monoclonal Ab (mAb) to SIRPα that also recognizes SIRPβ1 inhibited tumor formation by bladder and mammary cancer cells in mice, with this inhibitory effect being largely dependent on macrophages. The mAb to SIRPα promoted polarization of tumor-infiltrating macrophages toward an antitumorigenic phenotype, resulting in the killing and phagocytosis of cancer cells by the macrophages. Ablation of SIRPα in mice did not prevent the inhibitory effect of the anti-SIRPα mAb on tumor formation or its promotion of the cancer cell-killing activity of macrophages, however. Moreover, knockdown of SIRPβ1 in macrophages attenuated the stimulatory effect of the anti-SIRPα mAb on the killing of cancer cells, whereas an mAb specific for SIRPβ1 mimicked the effect of the anti-SIRPα mAb. Our results thus suggest that monotherapy with Abs to SIRPα/SIRPβ1 induces antitumorigenic macrophages and thereby inhibits tumor growth and that SIRPβ1 is a potential target for cancer immunotherapy." @default.
• W4200232366 created "2021-12-31" @default.
• W4200232366 creator A5003171350 @default.
• W4200232366 creator A5006414128 @default.
• W4200232366 creator A5009161905 @default.
• W4200232366 creator A5011247022 @default.
• W4200232366 creator A5015449816 @default.
• W4200232366 creator A5034872553 @default.
• W4200232366 creator A5040350752 @default.
• W4200232366 creator A5051758334 @default.
• W4200232366 creator A5054548624 @default.
• W4200232366 creator A5071680544 @default.
• W4200232366 creator A5076120482 @default.
• W4200232366 creator A5091009184 @default.
• W4200232366 date "2021-12-23" @default.
• W4200232366 modified "2023-09-25" @default.
• W4200232366 title "Anticancer efficacy of monotherapy with antibodies to SIRPα/SIRPβ1 mediated by induction of antitumorigenic macrophages" @default.
• W4200232366 cites W1539312716 @default.
• W4200232366 cites W1678819970 @default.
• W4200232366 cites W188422528 @default.
• W4200232366 cites W1920011500 @default.
• W4200232366 cites W1920052832 @default.
• W4200232366 cites W1972581358 @default.
• W4200232366 cites W1973975275 @default.
• W4200232366 cites W1977929504 @default.
• W4200232366 cites W2026809196 @default.
• W4200232366 cites W2026878412 @default.
• W4200232366 cites W2027228821 @default.
• W4200232366 cites W2038331892 @default.
• W4200232366 cites W2043991982 @default.
• W4200232366 cites W2051731334 @default.
• W4200232366 cites W2055348159 @default.
• W4200232366 cites W2057025197 @default.
• W4200232366 cites W2063211029 @default.
• W4200232366 cites W2068653310 @default.
• W4200232366 cites W2076743146 @default.
• W4200232366 cites W2085863885 @default.
• W4200232366 cites W2097733789 @default.
• W4200232366 cites W2106545303 @default.
• W4200232366 cites W2116725410 @default.
• W4200232366 cites W2119167266 @default.
• W4200232366 cites W2130633620 @default.
• W4200232366 cites W2133346943 @default.
• W4200232366 cites W2136164578 @default.
• W4200232366 cites W2139418176 @default.
• W4200232366 cites W2149698238 @default.
• W4200232366 cites W2152192278 @default.
• W4200232366 cites W2158298066 @default.
• W4200232366 cites W2170756973 @default.
• W4200232366 cites W2579381410 @default.
• W4200232366 cites W2582686270 @default.
• W4200232366 cites W2594014934 @default.
• W4200232366 cites W2770192040 @default.
• W4200232366 cites W2793275933 @default.
• W4200232366 cites W2811247652 @default.
• W4200232366 cites W2914311347 @default.
• W4200232366 cites W2946503701 @default.
• W4200232366 cites W2963622158 @default.
• W4200232366 cites W2971006194 @default.
• W4200232366 cites W2973129586 @default.
• W4200232366 cites W3026871210 @default.
• W4200232366 cites W3092910755 @default.
• W4200232366 cites W3123180599 @default.
• W4200232366 cites W3137192301 @default.
• W4200232366 cites W3180778035 @default.
• W4200232366 doi "https://doi.org/10.1073/pnas.2109923118" @default.
• W4200232366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34949714" @default.
• W4200232366 hasPublicationYear "2021" @default.
• W4200232366 type Work @default.
• W4200232366 citedByCount "4" @default.
• W4200232366 countsByYear W42002323662022 @default.
• W4200232366 countsByYear W42002323662023 @default.
• W4200232366 crossrefType "journal-article" @default.
• W4200232366 hasAuthorship W4200232366A5003171350 @default.
• W4200232366 hasAuthorship W4200232366A5006414128 @default.
• W4200232366 hasAuthorship W4200232366A5009161905 @default.
• W4200232366 hasAuthorship W4200232366A5011247022 @default.
• W4200232366 hasAuthorship W4200232366A5015449816 @default.
• W4200232366 hasAuthorship W4200232366A5034872553 @default.
• W4200232366 hasAuthorship W4200232366A5040350752 @default.
• W4200232366 hasAuthorship W4200232366A5051758334 @default.
• W4200232366 hasAuthorship W4200232366A5054548624 @default.
• W4200232366 hasAuthorship W4200232366A5071680544 @default.
• W4200232366 hasAuthorship W4200232366A5076120482 @default.
• W4200232366 hasAuthorship W4200232366A5091009184 @default.
• W4200232366 hasBestOaLocation W42002323661 @default.
• W4200232366 hasConcept C121608353 @default.
• W4200232366 hasConcept C159654299 @default.
• W4200232366 hasConcept C160448771 @default.
• W4200232366 hasConcept C202751555 @default.
• W4200232366 hasConcept C203014093 @default.
• W4200232366 hasConcept C2777701055 @default.
• W4200232366 hasConcept C2779244956 @default.
• W4200232366 hasConcept C2780104668 @default.
• W4200232366 hasConcept C2780674031 @default.
• W4200232366 hasConcept C502942594 @default.
• W4200232366 hasConcept C542903549 @default.
• W4200232366 hasConcept C54355233 @default.
• W4200232366 hasConcept C55493867 @default.
• W4200232366 hasConcept C86803240 @default.

• next