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- W4200236476 endingPage "e003430" @default.
- W4200236476 startingPage "e003430" @default.
- W4200236476 abstract "Ferroptosis is a recently discovered form of regulated cell death that is morphologically, genetically, and biochemically distinct from apoptosis and necroptosis, and its potential use in anticancer therapy is emerging. The strong immunogenicity of (early) ferroptotic cancer cells broadens the current concept of immunogenic cell death and opens up new possibilities for cancer treatment. In particular, induction of immunogenic ferroptosis could be beneficial for patients with cancers resistant to apoptosis and necroptosis. However, ferroptotic cancer cells may be a rich source of oxidized lipids, which contribute to decreased phagocytosis and antigen cross-presentation by dendritic cells and thus may favor tumor evasion. This could explain the non-immunogenicity of late ferroptotic cells. Besides the presence of lactate in the tumor microenvironment, acidification and hypoxia are essential factors promoting ferroptosis resistance and affecting its immunogenicity. Here, we critically discuss the crucial mediators controlling the immunogenicity of ferroptosis that modulate the induction of antitumor immunity. We emphasize that it will be necessary to also identify the tolerogenic (ie, immunosuppressive) nature of ferroptosis, which can lead to tumor evasion." @default.
- W4200236476 created "2021-12-31" @default.
- W4200236476 creator A5016000274 @default.
- W4200236476 creator A5021886516 @default.
- W4200236476 creator A5043152750 @default.
- W4200236476 creator A5070953366 @default.
- W4200236476 date "2021-12-01" @default.
- W4200236476 modified "2023-10-15" @default.
- W4200236476 title "Immunogenic ferroptosis and where to find it?" @default.
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