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- W4200241504 abstract "Toxoplasma gondii develops a latent infection in the muscle and central nervous system that acts as a reservoir for acute-stage reactivation in vulnerable patients. Little is understood about how parasites manipulate host cells during latent infection and the impact this has on survival. We show that bradyzoites impart a unique transcriptional signature on infected host cells. Many of these transcriptional changes rely on protein export and result in the suppression of type I interferon (IFN) and IFNγ signaling more so than in acute stages. Loss of the protein export component, MYR1, abrogates transcriptional remodeling and prevents suppression of IFN signaling. Among the exported proteins, the inhibitor of STAT1 transcription (IST) plays a key role in limiting IFNγ signaling in bradyzoites. Furthermore, bradyzoite protein export protects host cells from IFNγ-mediated cell death, even when export is restricted to latent stages. These findings highlight the functional importance of host manipulation in Toxoplasma's bradyzoite stages." @default.
- W4200241504 created "2021-12-31" @default.
- W4200241504 creator A5006794579 @default.
- W4200241504 creator A5017657101 @default.
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- W4200241504 creator A5061463554 @default.
- W4200241504 creator A5088300561 @default.
- W4200241504 creator A5088878681 @default.
- W4200241504 date "2022-02-01" @default.
- W4200241504 modified "2023-10-15" @default.
- W4200241504 title "Transcriptional modification of host cells harboring Toxoplasma gondii bradyzoites prevents IFN gamma-mediated cell death" @default.
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