FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200242008> ?p ?o ?g. }

• W4200242008 endingPage "014105" @default.
• W4200242008 startingPage "014105" @default.
• W4200242008 abstract "Decellularized meniscal extracellular matrix (ECM) material holds great potential for meniscus repair and regeneration. Particularly, injectable ECM hydrogel is highly desirable for the minimally invasive treatment of irregularly shaped defects. Although regional-specific variations of the meniscus are well documented, no ECM hydrogel has been reported to simulate zonally specific microenvironments of the native meniscus. To fill the gap, different (outer, middle, and inner) zones of porcine menisci were separately decellularized. Then the regionally decellularized meniscal ECMs were solubilized by pepsin digestion, neutralized, and then form injectable hydrogels. The hydrogels were characterized in gelation behaviors and mechanical properties and seeded with bovine fibrochondrocytes to evaluate the regionally biochemical effects on the cell-matrix interactions. Our results showed that the decellularized inner meniscal ECM (IM) contained the greatest glycosaminoglycan (GAG) content and the least collagen content compared with the decellularized outer meniscal ECM (OM) and middle meniscal ECM (MM). The IM hydrogel showed lower compressive strength than the OM hydrogel. When encapsulated with fibrochondrocytes, the IM hydrogel accumulated more GAG, contracted to a greater extent and reached higher compressive strength than that of the OM hydrogel at 28 days. Our findings demonstrate that the regionally specific meniscal ECMs present biochemical variation and show various effects on the cell behaviors, thus providing information on how meniscal ECM hydrogels may be utilized to reconstruct the microenvironments of the native meniscus." @default.
• W4200242008 created "2021-12-31" @default.
• W4200242008 creator A5000863621 @default.
• W4200242008 creator A5007830637 @default.
• W4200242008 creator A5043978576 @default.
• W4200242008 creator A5049651368 @default.
• W4200242008 creator A5053575933 @default.
• W4200242008 date "2021-12-23" @default.
• W4200242008 modified "2023-10-13" @default.
• W4200242008 title "Regional-specific meniscal extracellular matrix hydrogels and their effects on cell–matrix interactions of fibrochondrocytes" @default.
• W4200242008 cites W1560201504 @default.
• W4200242008 cites W1710562978 @default.
• W4200242008 cites W1965285101 @default.
• W4200242008 cites W1970102846 @default.
• W4200242008 cites W1972766239 @default.
• W4200242008 cites W1982819885 @default.
• W4200242008 cites W1983772892 @default.
• W4200242008 cites W1984729535 @default.
• W4200242008 cites W1992889793 @default.
• W4200242008 cites W1997353326 @default.
• W4200242008 cites W1997547509 @default.
• W4200242008 cites W2003328208 @default.
• W4200242008 cites W2008466348 @default.
• W4200242008 cites W2008638687 @default.
• W4200242008 cites W2008835088 @default.
• W4200242008 cites W2010318304 @default.
• W4200242008 cites W2012732104 @default.
• W4200242008 cites W2013974672 @default.
• W4200242008 cites W2021311978 @default.
• W4200242008 cites W2024373705 @default.
• W4200242008 cites W2030640932 @default.
• W4200242008 cites W2034084493 @default.
• W4200242008 cites W2034462747 @default.
• W4200242008 cites W2042022714 @default.
• W4200242008 cites W2059486645 @default.
• W4200242008 cites W2061430585 @default.
• W4200242008 cites W2065387405 @default.
• W4200242008 cites W2074048048 @default.
• W4200242008 cites W2080068515 @default.
• W4200242008 cites W2107826597 @default.
• W4200242008 cites W2109839379 @default.
• W4200242008 cites W2120689844 @default.
• W4200242008 cites W2131205613 @default.
• W4200242008 cites W2134406568 @default.
• W4200242008 cites W2141420021 @default.
• W4200242008 cites W2141547693 @default.
• W4200242008 cites W2166392134 @default.
• W4200242008 cites W2277025359 @default.
• W4200242008 cites W2306869006 @default.
• W4200242008 cites W2307338281 @default.
• W4200242008 cites W2435004069 @default.
• W4200242008 cites W2558671976 @default.
• W4200242008 cites W2585875172 @default.
• W4200242008 cites W2605289781 @default.
• W4200242008 cites W3181250761 @default.
• W4200242008 doi "https://doi.org/10.1088/1748-605x/ac4178" @default.
• W4200242008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34883474" @default.
• W4200242008 hasPublicationYear "2021" @default.
• W4200242008 type Work @default.
• W4200242008 citedByCount "8" @default.
• W4200242008 countsByYear W42002420082022 @default.
• W4200242008 countsByYear W42002420082023 @default.
• W4200242008 crossrefType "journal-article" @default.
• W4200242008 hasAuthorship W4200242008A5000863621 @default.
• W4200242008 hasAuthorship W4200242008A5007830637 @default.
• W4200242008 hasAuthorship W4200242008A5043978576 @default.
• W4200242008 hasAuthorship W4200242008A5049651368 @default.
• W4200242008 hasAuthorship W4200242008A5053575933 @default.
• W4200242008 hasConcept C106487976 @default.
• W4200242008 hasConcept C108586683 @default.
• W4200242008 hasConcept C120665830 @default.
• W4200242008 hasConcept C121332964 @default.
• W4200242008 hasConcept C12554922 @default.
• W4200242008 hasConcept C136229726 @default.
• W4200242008 hasConcept C153074725 @default.
• W4200242008 hasConcept C159985019 @default.
• W4200242008 hasConcept C171056886 @default.
• W4200242008 hasConcept C185592680 @default.
• W4200242008 hasConcept C188027245 @default.
• W4200242008 hasConcept C189165786 @default.
• W4200242008 hasConcept C189178095 @default.
• W4200242008 hasConcept C190672674 @default.
• W4200242008 hasConcept C192562407 @default.
• W4200242008 hasConcept C49892992 @default.
• W4200242008 hasConcept C55493867 @default.
• W4200242008 hasConcept C61511704 @default.
• W4200242008 hasConcept C71924100 @default.
• W4200242008 hasConcept C86803240 @default.
• W4200242008 hasConcept C95444343 @default.
• W4200242008 hasConceptScore W4200242008C106487976 @default.
• W4200242008 hasConceptScore W4200242008C108586683 @default.
• W4200242008 hasConceptScore W4200242008C120665830 @default.
• W4200242008 hasConceptScore W4200242008C121332964 @default.
• W4200242008 hasConceptScore W4200242008C12554922 @default.
• W4200242008 hasConceptScore W4200242008C136229726 @default.
• W4200242008 hasConceptScore W4200242008C153074725 @default.
• W4200242008 hasConceptScore W4200242008C159985019 @default.
• W4200242008 hasConceptScore W4200242008C171056886 @default.

• next