FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200243670> ?p ?o ?g. }

• W4200243670 endingPage "1608" @default.
• W4200243670 startingPage "1598" @default.
• W4200243670 abstract "The interface between solid poly(lactic acid-co-glycolic acid), PLGA, and solvents is described by large-scale atomistic simulations for water, ethyl acetate, and the mixture of them at ambient conditions. Interactions at the interface are dominated by Coulomb forces for water and become overwhelmingly dispersive for the other two solvents. This effect drives a neat liquid-phase separation of the mixed solvent, with ethyl acetate covering the PLGA surface and water being segregated away from it. We explore with all-atom Molecular Dynamics the formation of macromolecular assemblies on the surface of the PLGA-solvent interface when DSPE-PEG, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol)n amine, is added to the solvent. By following in time the deposition of the DSPE-PEG macromolecules onto the PLGA surface, the mechanism of how nanopatches remain adsorbed to the surface despite the presence of the solvent is probed. These patches have a droplet-like aspect when formed at the PLGA-water interface that flatten in the PLGA-ethyl acetate interface case. Dispersive forces are dominant for the nanopatch adhesion to the surface, while electrostatic forces are dominant for keeping the solvent around the new formations. Considering the droplet-like patches as wetting the PLGA surface, we predict an effective wetting behavior at the water interface that fades significantly at the ethyl acetate interface. The predicted mechanism of PEG-lipid nanopatch formation may be generally applicable for tailoring the synthesis of asymmetric PLGA nanoparticles for specific drug delivery conditions." @default.
• W4200243670 created "2021-12-31" @default.
• W4200243670 creator A5007835682 @default.
• W4200243670 creator A5042238461 @default.
• W4200243670 date "2021-12-22" @default.
• W4200243670 modified "2023-09-26" @default.
• W4200243670 title "Distinctive Formation of PEG-Lipid Nanopatches onto Solid Polymer Surfaces Interfacing Solvents from Atomistic Simulation" @default.
• W4200243670 cites W1031578623 @default.
• W4200243670 cites W1954123273 @default.
• W4200243670 cites W1966078827 @default.
• W4200243670 cites W1976060195 @default.
• W4200243670 cites W1976161355 @default.
• W4200243670 cites W1978498560 @default.
• W4200243670 cites W1990879541 @default.
• W4200243670 cites W2007938236 @default.
• W4200243670 cites W2010976109 @default.
• W4200243670 cites W2015688756 @default.
• W4200243670 cites W2027579771 @default.
• W4200243670 cites W2027725351 @default.
• W4200243670 cites W2032644190 @default.
• W4200243670 cites W2035266068 @default.
• W4200243670 cites W2038445365 @default.
• W4200243670 cites W2043600955 @default.
• W4200243670 cites W2049475242 @default.
• W4200243670 cites W2057477511 @default.
• W4200243670 cites W2066685510 @default.
• W4200243670 cites W2067174909 @default.
• W4200243670 cites W2070803838 @default.
• W4200243670 cites W2081693079 @default.
• W4200243670 cites W2102537419 @default.
• W4200243670 cites W2107029002 @default.
• W4200243670 cites W2115677394 @default.
• W4200243670 cites W2139244140 @default.
• W4200243670 cites W2144438594 @default.
• W4200243670 cites W2147993766 @default.
• W4200243670 cites W2171268876 @default.
• W4200243670 cites W2323104785 @default.
• W4200243670 cites W2482781646 @default.
• W4200243670 cites W2483066629 @default.
• W4200243670 cites W2540491215 @default.
• W4200243670 cites W2546034113 @default.
• W4200243670 cites W2768434483 @default.
• W4200243670 cites W2987586387 @default.
• W4200243670 cites W3014614371 @default.
• W4200243670 cites W3025080581 @default.
• W4200243670 cites W3048327694 @default.
• W4200243670 cites W3111905401 @default.
• W4200243670 cites W3120474473 @default.
• W4200243670 cites W3135501747 @default.
• W4200243670 cites W3149314802 @default.
• W4200243670 cites W3207104757 @default.
• W4200243670 cites W3213940527 @default.
• W4200243670 cites W4206706389 @default.
• W4200243670 doi "https://doi.org/10.1021/acs.jpcb.1c07490" @default.
• W4200243670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34933557" @default.
• W4200243670 hasPublicationYear "2021" @default.
• W4200243670 type Work @default.
• W4200243670 citedByCount "1" @default.
• W4200243670 countsByYear W42002436702022 @default.
• W4200243670 crossrefType "journal-article" @default.
• W4200243670 hasAuthorship W4200243670A5007835682 @default.
• W4200243670 hasAuthorship W4200243670A5042238461 @default.
• W4200243670 hasConcept C127413603 @default.
• W4200243670 hasConcept C134514944 @default.
• W4200243670 hasConcept C147597530 @default.
• W4200243670 hasConcept C150394285 @default.
• W4200243670 hasConcept C155672457 @default.
• W4200243670 hasConcept C171250308 @default.
• W4200243670 hasConcept C178790620 @default.
• W4200243670 hasConcept C185592680 @default.
• W4200243670 hasConcept C188027245 @default.
• W4200243670 hasConcept C192562407 @default.
• W4200243670 hasConcept C2777516009 @default.
• W4200243670 hasConcept C2779858419 @default.
• W4200243670 hasConcept C2780165375 @default.
• W4200243670 hasConcept C2780471494 @default.
• W4200243670 hasConcept C42360764 @default.
• W4200243670 hasConcept C521977710 @default.
• W4200243670 hasConcept C59593255 @default.
• W4200243670 hasConcept C6556556 @default.
• W4200243670 hasConceptScore W4200243670C127413603 @default.
• W4200243670 hasConceptScore W4200243670C134514944 @default.
• W4200243670 hasConceptScore W4200243670C147597530 @default.
• W4200243670 hasConceptScore W4200243670C150394285 @default.
• W4200243670 hasConceptScore W4200243670C155672457 @default.
• W4200243670 hasConceptScore W4200243670C171250308 @default.
• W4200243670 hasConceptScore W4200243670C178790620 @default.
• W4200243670 hasConceptScore W4200243670C185592680 @default.
• W4200243670 hasConceptScore W4200243670C188027245 @default.
• W4200243670 hasConceptScore W4200243670C192562407 @default.
• W4200243670 hasConceptScore W4200243670C2777516009 @default.
• W4200243670 hasConceptScore W4200243670C2779858419 @default.
• W4200243670 hasConceptScore W4200243670C2780165375 @default.
• W4200243670 hasConceptScore W4200243670C2780471494 @default.
• W4200243670 hasConceptScore W4200243670C42360764 @default.
• W4200243670 hasConceptScore W4200243670C521977710 @default.
• W4200243670 hasConceptScore W4200243670C59593255 @default.
• W4200243670 hasConceptScore W4200243670C6556556 @default.

• next