FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200246576> ?p ?o ?g. }

• W4200246576 abstract "Abstract Delineating the origins and properties of antibodies elicited by SARS-CoV-2 infection and vaccination is critical for understanding their benefits and potential shortcomings. Therefore, we investigated the SARS-CoV-2 spike (S)-reactive B cell repertoire in unexposed individuals by flow cytometry and single-cell sequencing. We found that ∼82% of SARS-CoV-2 S-reactive B cells show a naive phenotype, which represents an unusually high fraction of total human naive B cells (∼0.1%). Approximately 10% of these naive S-reactive B cells shared an IGHV1-69/IGKV3-11 B cell receptor pairing, an enrichment of 18-fold compared to the complete naive repertoire. A proportion of memory B cells, comprising switched (∼0.05%) and unswitched B cells (∼0.04%), was also reactive with S and some of these cells were reactive with ADAMTS13, which is associated with thrombotic thrombocytopenia. Following SARS-CoV-2 infection, we report an average 37-fold enrichment of IGHV1-69/IGKV3-11 B cell receptor pairing in the S-reactive memory B cells compared to the unselected memory repertoire. This class of B cells targets a previously undefined non-neutralizing epitope on the S2 subunit that becomes exposed on S proteins used in approved vaccines when they transition away from the native pre-fusion state because of instability. These findings can help guide the improvement of SARS-CoV-2 vaccines." @default.
• W4200246576 created "2021-12-31" @default.
• W4200246576 creator A5001705409 @default.
• W4200246576 creator A5005699911 @default.
• W4200246576 creator A5011080180 @default.
• W4200246576 creator A5012655217 @default.
• W4200246576 creator A5014663623 @default.
• W4200246576 creator A5016322668 @default.
• W4200246576 creator A5019112442 @default.
• W4200246576 creator A5027561354 @default.
• W4200246576 creator A5030424496 @default.
• W4200246576 creator A5036808227 @default.
• W4200246576 creator A5038811871 @default.
• W4200246576 creator A5040453633 @default.
• W4200246576 creator A5042550634 @default.
• W4200246576 creator A5044912285 @default.
• W4200246576 creator A5048376079 @default.
• W4200246576 creator A5051405805 @default.
• W4200246576 creator A5051889611 @default.
• W4200246576 creator A5054708018 @default.
• W4200246576 creator A5057596527 @default.
• W4200246576 creator A5064484917 @default.
• W4200246576 creator A5065522081 @default.
• W4200246576 creator A5066839372 @default.
• W4200246576 creator A5069085431 @default.
• W4200246576 creator A5070999270 @default.
• W4200246576 creator A5071641744 @default.
• W4200246576 creator A5076488615 @default.
• W4200246576 creator A5078305928 @default.
• W4200246576 creator A5080591517 @default.
• W4200246576 creator A5085831667 @default.
• W4200246576 creator A5086096538 @default.
• W4200246576 creator A5087473572 @default.
• W4200246576 creator A5090053143 @default.
• W4200246576 date "2021-12-03" @default.
• W4200246576 modified "2023-09-28" @default.
• W4200246576 title "A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike" @default.
• W4200246576 cites W1968375364 @default.
• W4200246576 cites W1990636994 @default.
• W4200246576 cites W2028470175 @default.
• W4200246576 cites W2076449818 @default.
• W4200246576 cites W2101375662 @default.
• W4200246576 cites W2108234281 @default.
• W4200246576 cites W2115122333 @default.
• W4200246576 cites W2126114330 @default.
• W4200246576 cites W2132629607 @default.
• W4200246576 cites W2139517175 @default.
• W4200246576 cites W2161661741 @default.
• W4200246576 cites W2161815151 @default.
• W4200246576 cites W2210879955 @default.
• W4200246576 cites W2343191045 @default.
• W4200246576 cites W2587625522 @default.
• W4200246576 cites W2763927805 @default.
• W4200246576 cites W2899714098 @default.
• W4200246576 cites W2910384850 @default.
• W4200246576 cites W2951068818 @default.
• W4200246576 cites W3027204812 @default.
• W4200246576 cites W3034425032 @default.
• W4200246576 cites W3035459690 @default.
• W4200246576 cites W3036386821 @default.
• W4200246576 cites W3039066506 @default.
• W4200246576 cites W3042323010 @default.
• W4200246576 cites W3044420571 @default.
• W4200246576 cites W3044914269 @default.
• W4200246576 cites W3045149055 @default.
• W4200246576 cites W3047461618 @default.
• W4200246576 cites W3049142173 @default.
• W4200246576 cites W3084517954 @default.
• W4200246576 cites W3087128437 @default.
• W4200246576 cites W3092403777 @default.
• W4200246576 cites W3093800460 @default.
• W4200246576 cites W3096068717 @default.
• W4200246576 cites W3096867322 @default.
• W4200246576 cites W3105885548 @default.
• W4200246576 cites W3107981400 @default.
• W4200246576 cites W3111255098 @default.
• W4200246576 cites W3113645786 @default.
• W4200246576 cites W3117759033 @default.
• W4200246576 cites W3122290535 @default.
• W4200246576 cites W3129651179 @default.
• W4200246576 cites W3129930809 @default.
• W4200246576 cites W3131447319 @default.
• W4200246576 cites W3131728782 @default.
• W4200246576 cites W3132982761 @default.
• W4200246576 cites W3133645762 @default.
• W4200246576 cites W3135352975 @default.
• W4200246576 cites W3135841530 @default.
• W4200246576 cites W3137024653 @default.
• W4200246576 cites W3153508314 @default.
• W4200246576 cites W3155123963 @default.
• W4200246576 cites W3157116442 @default.
• W4200246576 cites W3159333387 @default.
• W4200246576 cites W3160252417 @default.
• W4200246576 cites W3163548599 @default.
• W4200246576 cites W3164256543 @default.
• W4200246576 cites W3164547793 @default.
• W4200246576 cites W3164692211 @default.
• W4200246576 cites W3168032537 @default.
• W4200246576 cites W3169591811 @default.
• W4200246576 cites W3170782268 @default.

• next