FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200248857> ?p ?o ?g. }

• W4200248857 endingPage "255" @default.
• W4200248857 startingPage "249" @default.
• W4200248857 abstract "Chitosan is a cationic biopolymer obtained from deacetylating chitin, a natural compound present in crustacean shell, fungi and exoskeleton of insects. Chitosan involves various applications, including as drug and gene delivery systems, as wound dressing material and scaffolds for tissue engineering, agriculture, textile, food and feed nanotechnology, and in wastewater treatments. Chitosan-TPP particle has been figured out as the most important and stable nanoparticle for chitosan application in various fields.In this study, chitosan was chemically modified by sodium tripolyphosphate (TPP). Afterward, TPP-chitosan was radiolabeled with the gallium-67 radionuclide. The effect of several factors on labeling yield, such as chitosan solubility, acidity and concentration of TPPchitosan solution, and incubation time with gallium-67, were investigated.To prepare [67Ga] gallium-chitosan complex, chitosan (0.5 ml) was dissolved in 2.2 mCi of [67Ga] gallium chloride solution. The obtained solution was stirred for 5 min and then kept for 30 min at room temperature. The radiochemical purity and radiolabeling yield were measured via radiochromatography, which was performed by using a radio thin-layer chromatography (TLC) scanner instrument. To investigate the effect of chitosan kind and concentration on the labeling yield, two kinds of chitosan (acid-soluble chitosan and water-soluble chitosan) at two different concentrations (1% and 0.5%) and different pH were used. In addition, labeling efficiency and stability of the 67Ga-TPP-chitosan complex (acidic/water soluble chitosan) at both concentrations (0.5 and 1%) and at room temperature were assessed for 30, 45 and 60 min.The incubation time did not have any significant effect on labeling yield. The acidic soluble chitosan exhibited the highest radiolabeling yield at pH=9.3-10.4, while water-soluble chitosan showed the highest radiolabeling yield at pH > 5. Also, the prepared complex was stable in the final solution at room temperature and could even be used 24 hours after preparation for further application.Taken together, the TPP-modified water-soluble chitosan at the concentration of 0.5 % depicted the highest radiochemical yield (>95 %) in the optimized condition (pH= 6.2- 7.6). Therefore, TPP modified water-soluble chitosan can prove to be an effective carrier for therapeutic radionuclides in tumor treatment." @default.
• W4200248857 created "2021-12-31" @default.
• W4200248857 creator A5003292358 @default.
• W4200248857 creator A5011145728 @default.
• W4200248857 creator A5027981221 @default.
• W4200248857 creator A5046170018 @default.
• W4200248857 creator A5069148878 @default.
• W4200248857 creator A5080063094 @default.
• W4200248857 date "2022-09-01" @default.
• W4200248857 modified "2023-09-28" @default.
• W4200248857 title "Effect of pH Variation on Cross-Linking of Water-Soluble and Acid- Soluble Chitosan with Sodium Tripolyphosphate and Gallium-67" @default.
• W4200248857 cites W1964713492 @default.
• W4200248857 cites W1968017412 @default.
• W4200248857 cites W1981861292 @default.
• W4200248857 cites W1987344321 @default.
• W4200248857 cites W2000970639 @default.
• W4200248857 cites W2002678616 @default.
• W4200248857 cites W2004509081 @default.
• W4200248857 cites W2012315586 @default.
• W4200248857 cites W2021932233 @default.
• W4200248857 cites W2028531434 @default.
• W4200248857 cites W2028929452 @default.
• W4200248857 cites W2034191622 @default.
• W4200248857 cites W2034805293 @default.
• W4200248857 cites W2037306331 @default.
• W4200248857 cites W2038608647 @default.
• W4200248857 cites W2066662632 @default.
• W4200248857 cites W2071772651 @default.
• W4200248857 cites W2082232502 @default.
• W4200248857 cites W2086082816 @default.
• W4200248857 cites W2098337093 @default.
• W4200248857 cites W2104229644 @default.
• W4200248857 cites W2152276464 @default.
• W4200248857 cites W2273718512 @default.
• W4200248857 cites W2333862768 @default.
• W4200248857 cites W2496549216 @default.
• W4200248857 cites W2752674114 @default.
• W4200248857 cites W78285312 @default.
• W4200248857 doi "https://doi.org/10.2174/1874471015666211220094433" @default.
• W4200248857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34931974" @default.
• W4200248857 hasPublicationYear "2022" @default.
• W4200248857 type Work @default.
• W4200248857 citedByCount "0" @default.
• W4200248857 crossrefType "journal-article" @default.
• W4200248857 hasAuthorship W4200248857A5003292358 @default.
• W4200248857 hasAuthorship W4200248857A5011145728 @default.
• W4200248857 hasAuthorship W4200248857A5027981221 @default.
• W4200248857 hasAuthorship W4200248857A5046170018 @default.
• W4200248857 hasAuthorship W4200248857A5069148878 @default.
• W4200248857 hasAuthorship W4200248857A5080063094 @default.
• W4200248857 hasConcept C134121241 @default.
• W4200248857 hasConcept C13965031 @default.
• W4200248857 hasConcept C155574463 @default.
• W4200248857 hasConcept C178790620 @default.
• W4200248857 hasConcept C184651966 @default.
• W4200248857 hasConcept C185592680 @default.
• W4200248857 hasConcept C191897082 @default.
• W4200248857 hasConcept C192562407 @default.
• W4200248857 hasConcept C2778636629 @default.
• W4200248857 hasConcept C2778695967 @default.
• W4200248857 hasConcept C2779732960 @default.
• W4200248857 hasConcept C2781088250 @default.
• W4200248857 hasConcept C43617362 @default.
• W4200248857 hasConcept C521977710 @default.
• W4200248857 hasConceptScore W4200248857C134121241 @default.
• W4200248857 hasConceptScore W4200248857C13965031 @default.
• W4200248857 hasConceptScore W4200248857C155574463 @default.
• W4200248857 hasConceptScore W4200248857C178790620 @default.
• W4200248857 hasConceptScore W4200248857C184651966 @default.
• W4200248857 hasConceptScore W4200248857C185592680 @default.
• W4200248857 hasConceptScore W4200248857C191897082 @default.
• W4200248857 hasConceptScore W4200248857C192562407 @default.
• W4200248857 hasConceptScore W4200248857C2778636629 @default.
• W4200248857 hasConceptScore W4200248857C2778695967 @default.
• W4200248857 hasConceptScore W4200248857C2779732960 @default.
• W4200248857 hasConceptScore W4200248857C2781088250 @default.
• W4200248857 hasConceptScore W4200248857C43617362 @default.
• W4200248857 hasConceptScore W4200248857C521977710 @default.
• W4200248857 hasFunder F4320324820 @default.
• W4200248857 hasIssue "3" @default.
• W4200248857 hasLocation W42002488571 @default.
• W4200248857 hasLocation W42002488572 @default.
• W4200248857 hasOpenAccess W4200248857 @default.
• W4200248857 hasPrimaryLocation W42002488571 @default.
• W4200248857 hasRelatedWork W1912808485 @default.
• W4200248857 hasRelatedWork W2001670618 @default.
• W4200248857 hasRelatedWork W2079264669 @default.
• W4200248857 hasRelatedWork W2091473984 @default.
• W4200248857 hasRelatedWork W2389614812 @default.
• W4200248857 hasRelatedWork W2502614602 @default.
• W4200248857 hasRelatedWork W3166482593 @default.
• W4200248857 hasRelatedWork W3175007457 @default.
• W4200248857 hasRelatedWork W4313654671 @default.
• W4200248857 hasRelatedWork W4318475768 @default.
• W4200248857 hasVolume "15" @default.
• W4200248857 isParatext "false" @default.
• W4200248857 isRetracted "false" @default.
• W4200248857 workType "article" @default.