Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200249382> ?p ?o ?g. }
- W4200249382 abstract "Tristetraprolin (TTP), an important immunosuppressive protein regulating mRNA decay through recognition of the AU-rich elements (AREs) within the 3'-UTRs of mRNAs, participates in the pathogenesis of liver diseases. However, whether TTP regulates mRNA stability through other mechanisms remains poorly understood. Here, we report that TTP was upregulated in acute liver failure (ALF), resulting in decreased mRNA stabilities of CCL2 and CCL5 through promotion of N6-methyladenosine (m6A) mRNA methylation. Overexpression of TTP could markedly ameliorate hepatic injury in vivo. TTP regulated the mRNA stabilization of CCL2 and CCL5. Interestingly, increased m6A methylation in CCL2 and CCL5 mRNAs promoted TTP-mediated RNA destabilization. Moreover, induction of TTP upregulated expression levels of WT1 associated protein, methyltransferase like 14, and YT521-B homology N6-methyladenosine RNA binding protein 2, which encode enzymes regulating m6A methylation, resulting in a global increase of m6A methylation and amelioration of liver injury due to enhanced degradation of CCL2 and CCL5. These findings suggest a potentially novel mechanism by which TTP modulates mRNA stabilities of CCL2 and CCL5 through m6A RNA methylation, which is involved in the pathogenesis of ALF." @default.
- W4200249382 created "2021-12-31" @default.
- W4200249382 creator A5027119086 @default.
- W4200249382 creator A5029699016 @default.
- W4200249382 creator A5038158677 @default.
- W4200249382 creator A5049396071 @default.
- W4200249382 creator A5061899878 @default.
- W4200249382 creator A5063552974 @default.
- W4200249382 creator A5071187832 @default.
- W4200249382 creator A5074364344 @default.
- W4200249382 creator A5079782420 @default.
- W4200249382 creator A5085549483 @default.
- W4200249382 date "2021-12-08" @default.
- W4200249382 modified "2023-10-18" @default.
- W4200249382 title "TTP protects against acute liver failure by regulating CCL2 and CCL5 through m6A RNA methylation" @default.
- W4200249382 cites W1966691011 @default.
- W4200249382 cites W1991527255 @default.
- W4200249382 cites W1991807334 @default.
- W4200249382 cites W2010081999 @default.
- W4200249382 cites W2033260525 @default.
- W4200249382 cites W2042556780 @default.
- W4200249382 cites W2064128480 @default.
- W4200249382 cites W2064261527 @default.
- W4200249382 cites W2083412264 @default.
- W4200249382 cites W2110385952 @default.
- W4200249382 cites W2125172467 @default.
- W4200249382 cites W2129035585 @default.
- W4200249382 cites W2136547076 @default.
- W4200249382 cites W2304724046 @default.
- W4200249382 cites W2335972659 @default.
- W4200249382 cites W2368380279 @default.
- W4200249382 cites W2399007766 @default.
- W4200249382 cites W2492767679 @default.
- W4200249382 cites W2565958256 @default.
- W4200249382 cites W2575132696 @default.
- W4200249382 cites W2627064270 @default.
- W4200249382 cites W2755905165 @default.
- W4200249382 cites W2791790309 @default.
- W4200249382 cites W2810177111 @default.
- W4200249382 cites W2884588152 @default.
- W4200249382 cites W2886443559 @default.
- W4200249382 cites W2892035545 @default.
- W4200249382 cites W2898209133 @default.
- W4200249382 cites W2943595344 @default.
- W4200249382 cites W2970631046 @default.
- W4200249382 cites W2971726193 @default.
- W4200249382 cites W2983597422 @default.
- W4200249382 cites W2985625266 @default.
- W4200249382 cites W2994360576 @default.
- W4200249382 cites W2998824714 @default.
- W4200249382 cites W3009703063 @default.
- W4200249382 cites W4211175126 @default.
- W4200249382 cites W4242966060 @default.
- W4200249382 doi "https://doi.org/10.1172/jci.insight.149276" @default.
- W4200249382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34877932" @default.
- W4200249382 hasPublicationYear "2021" @default.
- W4200249382 type Work @default.
- W4200249382 citedByCount "12" @default.
- W4200249382 countsByYear W42002493822022 @default.
- W4200249382 countsByYear W42002493822023 @default.
- W4200249382 crossrefType "journal-article" @default.
- W4200249382 hasAuthorship W4200249382A5027119086 @default.
- W4200249382 hasAuthorship W4200249382A5029699016 @default.
- W4200249382 hasAuthorship W4200249382A5038158677 @default.
- W4200249382 hasAuthorship W4200249382A5049396071 @default.
- W4200249382 hasAuthorship W4200249382A5061899878 @default.
- W4200249382 hasAuthorship W4200249382A5063552974 @default.
- W4200249382 hasAuthorship W4200249382A5071187832 @default.
- W4200249382 hasAuthorship W4200249382A5074364344 @default.
- W4200249382 hasAuthorship W4200249382A5079782420 @default.
- W4200249382 hasAuthorship W4200249382A5085549483 @default.
- W4200249382 hasBestOaLocation W42002493821 @default.
- W4200249382 hasConcept C104317684 @default.
- W4200249382 hasConcept C105580179 @default.
- W4200249382 hasConcept C116484652 @default.
- W4200249382 hasConcept C127561419 @default.
- W4200249382 hasConcept C13373296 @default.
- W4200249382 hasConcept C153911025 @default.
- W4200249382 hasConcept C154317977 @default.
- W4200249382 hasConcept C170493617 @default.
- W4200249382 hasConcept C185592680 @default.
- W4200249382 hasConcept C202751555 @default.
- W4200249382 hasConcept C2775963939 @default.
- W4200249382 hasConcept C2909367411 @default.
- W4200249382 hasConcept C2909856833 @default.
- W4200249382 hasConcept C33288867 @default.
- W4200249382 hasConcept C41282012 @default.
- W4200249382 hasConcept C502942594 @default.
- W4200249382 hasConcept C55493867 @default.
- W4200249382 hasConcept C67705224 @default.
- W4200249382 hasConcept C79484868 @default.
- W4200249382 hasConcept C86803240 @default.
- W4200249382 hasConcept C91965660 @default.
- W4200249382 hasConcept C95444343 @default.
- W4200249382 hasConceptScore W4200249382C104317684 @default.
- W4200249382 hasConceptScore W4200249382C105580179 @default.
- W4200249382 hasConceptScore W4200249382C116484652 @default.
- W4200249382 hasConceptScore W4200249382C127561419 @default.
- W4200249382 hasConceptScore W4200249382C13373296 @default.
- W4200249382 hasConceptScore W4200249382C153911025 @default.