FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200253938> ?p ?o ?g. }

• W4200253938 endingPage "121373" @default.
• W4200253938 startingPage "121373" @default.
• W4200253938 abstract "The distributional homogeneity of chemicals is a key parameter of solid pharmaceutical formulations. Indeed, it may affect the efficacy of the drug and consequently its safety. Chemical imaging offers a unique insight enabling the visualisation of the different constituents of a pharmaceutical tablet. It allows identifying ingredients poorly distributed offering the possibility to optimize the process parameters or to adapt characteristics of incoming raw materials to increase the final product quality. Among the available chemical imaging tools, Raman imaging is one of the most widely used since it offers a high spatial resolution with well-resolved peaks resulting in a high spectral specificity. However, Raman imaging suffers from sample autofluorescence and long acquisition times. Recently commercialised, laser direct infrared reflectance imaging (LDIR) is a quantum cascade laser (QCL) based imaging technique that offers the opportunity to rapidly analyse samples. In this study, a typical pharmaceutical formulation blend composed of two active pharmaceutical ingredients and three excipients was aliquoted at different mixing timepoints. The collected aliquots were tableted and analysed using both Raman and LDIR imaging. The distributional homogeneity indexes of one active ingredient image were then computed and compared. The results show that both techniques achieved similar conclusions. However, the analysis times were drastically different. While Raman imaging required a total analysis time of 4 h per tablet to obtain the distribution map of acetylsalicylic acid with a step size of 100 µm, it only took 7.5 min to achieve the same result with LDIR. The results obtained in the present study show that LDIR is a promising technique for the analysis of pharmaceutical formulations and that it could be a valuable tool when developing new pharmaceutical formulations." @default.
• W4200253938 created "2021-12-31" @default.
• W4200253938 creator A5002218951 @default.
• W4200253938 creator A5008555668 @default.
• W4200253938 creator A5034817041 @default.
• W4200253938 creator A5034938830 @default.
• W4200253938 creator A5059709965 @default.
• W4200253938 creator A5091692724 @default.
• W4200253938 date "2022-01-01" @default.
• W4200253938 modified "2023-10-17" @default.
• W4200253938 title "Evaluation of distributional homogeneity of pharmaceutical formulation using laser direct infrared imaging" @default.
• W4200253938 cites W1964576728 @default.
• W4200253938 cites W1967542684 @default.
• W4200253938 cites W1989485702 @default.
• W4200253938 cites W2002769882 @default.
• W4200253938 cites W2034706425 @default.
• W4200253938 cites W2039475346 @default.
• W4200253938 cites W2050734633 @default.
• W4200253938 cites W2062410839 @default.
• W4200253938 cites W2066214560 @default.
• W4200253938 cites W2094056341 @default.
• W4200253938 cites W2103749394 @default.
• W4200253938 cites W2109606373 @default.
• W4200253938 cites W2182668067 @default.
• W4200253938 cites W2560782732 @default.
• W4200253938 cites W2758285382 @default.
• W4200253938 cites W2913486463 @default.
• W4200253938 cites W2976438518 @default.
• W4200253938 cites W3006659107 @default.
• W4200253938 cites W3024016061 @default.
• W4200253938 cites W3048096880 @default.
• W4200253938 cites W4250278035 @default.
• W4200253938 doi "https://doi.org/10.1016/j.ijpharm.2021.121373" @default.
• W4200253938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34906650" @default.
• W4200253938 hasPublicationYear "2022" @default.
• W4200253938 type Work @default.
• W4200253938 citedByCount "6" @default.
• W4200253938 countsByYear W42002539382022 @default.
• W4200253938 countsByYear W42002539382023 @default.
• W4200253938 crossrefType "journal-article" @default.
• W4200253938 hasAuthorship W4200253938A5002218951 @default.
• W4200253938 hasAuthorship W4200253938A5008555668 @default.
• W4200253938 hasAuthorship W4200253938A5034817041 @default.
• W4200253938 hasAuthorship W4200253938A5034938830 @default.
• W4200253938 hasAuthorship W4200253938A5059709965 @default.
• W4200253938 hasAuthorship W4200253938A5091692724 @default.
• W4200253938 hasConcept C119857082 @default.
• W4200253938 hasConcept C120665830 @default.
• W4200253938 hasConcept C121332964 @default.
• W4200253938 hasConcept C136229726 @default.
• W4200253938 hasConcept C142259097 @default.
• W4200253938 hasConcept C154945302 @default.
• W4200253938 hasConcept C159078339 @default.
• W4200253938 hasConcept C185592680 @default.
• W4200253938 hasConcept C186060115 @default.
• W4200253938 hasConcept C192562407 @default.
• W4200253938 hasConcept C2778576202 @default.
• W4200253938 hasConcept C40003534 @default.
• W4200253938 hasConcept C41008148 @default.
• W4200253938 hasConcept C43617362 @default.
• W4200253938 hasConcept C45904493 @default.
• W4200253938 hasConcept C520434653 @default.
• W4200253938 hasConcept C60644358 @default.
• W4200253938 hasConcept C65597285 @default.
• W4200253938 hasConcept C71924100 @default.
• W4200253938 hasConcept C86803240 @default.
• W4200253938 hasConceptScore W4200253938C119857082 @default.
• W4200253938 hasConceptScore W4200253938C120665830 @default.
• W4200253938 hasConceptScore W4200253938C121332964 @default.
• W4200253938 hasConceptScore W4200253938C136229726 @default.
• W4200253938 hasConceptScore W4200253938C142259097 @default.
• W4200253938 hasConceptScore W4200253938C154945302 @default.
• W4200253938 hasConceptScore W4200253938C159078339 @default.
• W4200253938 hasConceptScore W4200253938C185592680 @default.
• W4200253938 hasConceptScore W4200253938C186060115 @default.
• W4200253938 hasConceptScore W4200253938C192562407 @default.
• W4200253938 hasConceptScore W4200253938C2778576202 @default.
• W4200253938 hasConceptScore W4200253938C40003534 @default.
• W4200253938 hasConceptScore W4200253938C41008148 @default.
• W4200253938 hasConceptScore W4200253938C43617362 @default.
• W4200253938 hasConceptScore W4200253938C45904493 @default.
• W4200253938 hasConceptScore W4200253938C520434653 @default.
• W4200253938 hasConceptScore W4200253938C60644358 @default.
• W4200253938 hasConceptScore W4200253938C65597285 @default.
• W4200253938 hasConceptScore W4200253938C71924100 @default.
• W4200253938 hasConceptScore W4200253938C86803240 @default.
• W4200253938 hasLocation W42002539381 @default.
• W4200253938 hasLocation W42002539382 @default.
• W4200253938 hasOpenAccess W4200253938 @default.
• W4200253938 hasPrimaryLocation W42002539381 @default.
• W4200253938 hasRelatedWork W2032756100 @default.
• W4200253938 hasRelatedWork W2034706425 @default.
• W4200253938 hasRelatedWork W2050412315 @default.
• W4200253938 hasRelatedWork W2094921070 @default.
• W4200253938 hasRelatedWork W2107944544 @default.
• W4200253938 hasRelatedWork W2899084033 @default.
• W4200253938 hasRelatedWork W2945498905 @default.
• W4200253938 hasRelatedWork W2965306756 @default.

• next