Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200254823> ?p ?o ?g. }
- W4200254823 endingPage "338" @default.
- W4200254823 startingPage "326" @default.
- W4200254823 abstract "The controlled folding of synthetic polymer chains into single-chain polymeric nanoparticles (SCPNs) of defined size and shape in water is a viable way to create compartmentalized, nanometer-sized structures for a range of biological applications. Understanding the relationship between the polymer's microstructure and the stability of folded structures is crucial to achieving desired applications. Here, we introduce the solvatochromic dye Nile red into SCPNs and apply a combination of spectroscopic and microscopic techniques to relate polymer microstructure to nanoparticle stability in complex biological media and cellular environments. Our experimental data show that the polymer's microstructure has little effect on the stability of SCPNs in biological media and cytoplasm of living cells, but only SCPNs comprising supramolecular benzene-1,3,5-tricarboxamide (BTA) motifs showed good stability in lysosomes. The results indicate that the polymer's microstructure is vital to ensure nanoparticle stability in highly competitive environments: both hydrophobic collapse and a structured interior are required. Our study provides an accessible way of probing the stability of SCPNs in cellular environments and paves the way for designing highly stable SCPNs for efficient bio-orthogonal catalysis and sensing applications." @default.
- W4200254823 created "2021-12-31" @default.
- W4200254823 creator A5003030183 @default.
- W4200254823 creator A5030922807 @default.
- W4200254823 creator A5065127369 @default.
- W4200254823 date "2021-12-14" @default.
- W4200254823 modified "2023-10-01" @default.
- W4200254823 title "Elucidating the Stability of Single-Chain Polymeric Nanoparticles in Biological Media and Living Cells" @default.
- W4200254823 cites W1578860249 @default.
- W4200254823 cites W1586605199 @default.
- W4200254823 cites W1839620119 @default.
- W4200254823 cites W1969585687 @default.
- W4200254823 cites W1974069801 @default.
- W4200254823 cites W1976915466 @default.
- W4200254823 cites W1984309150 @default.
- W4200254823 cites W1989987616 @default.
- W4200254823 cites W1990052292 @default.
- W4200254823 cites W2000257842 @default.
- W4200254823 cites W2002182083 @default.
- W4200254823 cites W2008319673 @default.
- W4200254823 cites W2012838605 @default.
- W4200254823 cites W2015100076 @default.
- W4200254823 cites W2015775000 @default.
- W4200254823 cites W2027483175 @default.
- W4200254823 cites W2033255593 @default.
- W4200254823 cites W2043461452 @default.
- W4200254823 cites W2046926512 @default.
- W4200254823 cites W2050886209 @default.
- W4200254823 cites W2053978383 @default.
- W4200254823 cites W2059688822 @default.
- W4200254823 cites W2066706820 @default.
- W4200254823 cites W2068145833 @default.
- W4200254823 cites W2072071867 @default.
- W4200254823 cites W2090391132 @default.
- W4200254823 cites W2123302568 @default.
- W4200254823 cites W2147118544 @default.
- W4200254823 cites W2147868045 @default.
- W4200254823 cites W2158117253 @default.
- W4200254823 cites W2167585670 @default.
- W4200254823 cites W2202224940 @default.
- W4200254823 cites W2231449758 @default.
- W4200254823 cites W2317863224 @default.
- W4200254823 cites W2329849793 @default.
- W4200254823 cites W2332518451 @default.
- W4200254823 cites W2460414839 @default.
- W4200254823 cites W2509993152 @default.
- W4200254823 cites W2510960450 @default.
- W4200254823 cites W2566871825 @default.
- W4200254823 cites W2568046654 @default.
- W4200254823 cites W2614727044 @default.
- W4200254823 cites W2621452398 @default.
- W4200254823 cites W2626438806 @default.
- W4200254823 cites W2743327261 @default.
- W4200254823 cites W2766249461 @default.
- W4200254823 cites W2766327334 @default.
- W4200254823 cites W2787880135 @default.
- W4200254823 cites W2884441747 @default.
- W4200254823 cites W2887404996 @default.
- W4200254823 cites W2888188022 @default.
- W4200254823 cites W2889080889 @default.
- W4200254823 cites W2892217299 @default.
- W4200254823 cites W2894855870 @default.
- W4200254823 cites W2898842426 @default.
- W4200254823 cites W2901575037 @default.
- W4200254823 cites W2934895026 @default.
- W4200254823 cites W2946379211 @default.
- W4200254823 cites W2952809992 @default.
- W4200254823 cites W2958943445 @default.
- W4200254823 cites W2969560376 @default.
- W4200254823 cites W3005614740 @default.
- W4200254823 cites W3092014131 @default.
- W4200254823 cites W3096692816 @default.
- W4200254823 cites W3117664039 @default.
- W4200254823 cites W3181753253 @default.
- W4200254823 doi "https://doi.org/10.1021/acs.biomac.1c01291" @default.
- W4200254823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34904821" @default.
- W4200254823 hasPublicationYear "2021" @default.
- W4200254823 type Work @default.
- W4200254823 citedByCount "15" @default.
- W4200254823 countsByYear W42002548232022 @default.
- W4200254823 countsByYear W42002548232023 @default.
- W4200254823 crossrefType "journal-article" @default.
- W4200254823 hasAuthorship W4200254823A5003030183 @default.
- W4200254823 hasAuthorship W4200254823A5030922807 @default.
- W4200254823 hasAuthorship W4200254823A5065127369 @default.
- W4200254823 hasBestOaLocation W42002548232 @default.
- W4200254823 hasConcept C121332964 @default.
- W4200254823 hasConcept C127413603 @default.
- W4200254823 hasConcept C155672457 @default.
- W4200254823 hasConcept C159985019 @default.
- W4200254823 hasConcept C171250308 @default.
- W4200254823 hasConcept C178790620 @default.
- W4200254823 hasConcept C185592680 @default.
- W4200254823 hasConcept C191897082 @default.
- W4200254823 hasConcept C192562407 @default.
- W4200254823 hasConcept C2778086801 @default.
- W4200254823 hasConcept C32909587 @default.
- W4200254823 hasConcept C42360764 @default.