Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200257675> ?p ?o ?g. }
- W4200257675 endingPage "2012" @default.
- W4200257675 startingPage "1997" @default.
- W4200257675 abstract "Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial contribution of diabetes mellitus (DM) as a risk factor associated with increased cancer incidence and mortality in many human neoplasms, including gastric cancer (GC). DM is considered a systemic inflammatory disease and therefore, this inflammatory status may have profound effects on the tumor microenvironment (TME), particularly by driving many molecular mechanisms to generate a more aggressive TME. DM is an active driver in the modification of the behavior of many cell components of the TME as well as altering the mechanical properties of the extracellular matrix (ECM), leading to an increased ECM stiffening. Additionally, DM can alter many cellular signaling mechanisms and thus favoring tumor growth, invasion, and metastatic potential, as well as key elements in regulating cellular functions and cross-talks, such as the microRNAs network, the production, and cargo of exosomes, the metabolism of cell stroma and resistance to hypoxia. In the present review, we intend to highlight the mechanistic contributions of DM to the remodeling of TME in GC." @default.
- W4200257675 created "2021-12-31" @default.
- W4200257675 creator A5004117824 @default.
- W4200257675 creator A5022078939 @default.
- W4200257675 creator A5028273500 @default.
- W4200257675 creator A5033761928 @default.
- W4200257675 creator A5038469257 @default.
- W4200257675 creator A5046489677 @default.
- W4200257675 creator A5050441374 @default.
- W4200257675 creator A5055232515 @default.
- W4200257675 creator A5070904079 @default.
- W4200257675 creator A5089429231 @default.
- W4200257675 date "2021-12-15" @default.
- W4200257675 modified "2023-10-18" @default.
- W4200257675 title "Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer" @default.
- W4200257675 cites W1486117034 @default.
- W4200257675 cites W1723983223 @default.
- W4200257675 cites W1765981352 @default.
- W4200257675 cites W1967482096 @default.
- W4200257675 cites W1968139563 @default.
- W4200257675 cites W1968234252 @default.
- W4200257675 cites W1977985325 @default.
- W4200257675 cites W1980763614 @default.
- W4200257675 cites W1983359649 @default.
- W4200257675 cites W1984265481 @default.
- W4200257675 cites W1993999038 @default.
- W4200257675 cites W2000054651 @default.
- W4200257675 cites W2001717792 @default.
- W4200257675 cites W2002549465 @default.
- W4200257675 cites W2005159316 @default.
- W4200257675 cites W2007197271 @default.
- W4200257675 cites W2011988431 @default.
- W4200257675 cites W2012915718 @default.
- W4200257675 cites W2012985260 @default.
- W4200257675 cites W2013105546 @default.
- W4200257675 cites W2022380145 @default.
- W4200257675 cites W2024315189 @default.
- W4200257675 cites W2036554445 @default.
- W4200257675 cites W2044437167 @default.
- W4200257675 cites W2044801187 @default.
- W4200257675 cites W2046751492 @default.
- W4200257675 cites W2050332600 @default.
- W4200257675 cites W2050817546 @default.
- W4200257675 cites W2051190668 @default.
- W4200257675 cites W2053564705 @default.
- W4200257675 cites W2058150019 @default.
- W4200257675 cites W2060122755 @default.
- W4200257675 cites W2061123122 @default.
- W4200257675 cites W2062112404 @default.
- W4200257675 cites W2071520055 @default.
- W4200257675 cites W2072451938 @default.
- W4200257675 cites W2073134365 @default.
- W4200257675 cites W2079613095 @default.
- W4200257675 cites W2079748887 @default.
- W4200257675 cites W2081540798 @default.
- W4200257675 cites W2084536221 @default.
- W4200257675 cites W2089171551 @default.
- W4200257675 cites W2090241102 @default.
- W4200257675 cites W2092495156 @default.
- W4200257675 cites W2096623507 @default.
- W4200257675 cites W2103049890 @default.
- W4200257675 cites W2110569100 @default.
- W4200257675 cites W2117692326 @default.
- W4200257675 cites W2118046722 @default.
- W4200257675 cites W2119041494 @default.
- W4200257675 cites W2124290637 @default.
- W4200257675 cites W2127665744 @default.
- W4200257675 cites W2129067322 @default.
- W4200257675 cites W2138549869 @default.
- W4200257675 cites W2138575566 @default.
- W4200257675 cites W2141145072 @default.
- W4200257675 cites W2150367899 @default.
- W4200257675 cites W2151115143 @default.
- W4200257675 cites W2154677603 @default.
- W4200257675 cites W2156554634 @default.
- W4200257675 cites W2157441872 @default.
- W4200257675 cites W2157908163 @default.
- W4200257675 cites W2159999569 @default.
- W4200257675 cites W2160504871 @default.
- W4200257675 cites W2162294485 @default.
- W4200257675 cites W2166211643 @default.
- W4200257675 cites W2167715370 @default.
- W4200257675 cites W2173523334 @default.
- W4200257675 cites W2183857458 @default.
- W4200257675 cites W2184554934 @default.
- W4200257675 cites W2256076111 @default.
- W4200257675 cites W2302447233 @default.
- W4200257675 cites W2394782024 @default.
- W4200257675 cites W2479398291 @default.
- W4200257675 cites W2512899508 @default.
- W4200257675 cites W2517048970 @default.
- W4200257675 cites W2517351959 @default.
- W4200257675 cites W2519479884 @default.
- W4200257675 cites W2520632143 @default.
- W4200257675 cites W2552487941 @default.
- W4200257675 cites W2588923514 @default.
- W4200257675 cites W2592483511 @default.
- W4200257675 cites W2602651379 @default.