FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200260818> ?p ?o ?g. }

• W4200260818 endingPage "1865" @default.
• W4200260818 startingPage "1865" @default.
• W4200260818 abstract "Previous studies have reported beneficial effects of NADPH oxidase 4 (NOX4) inhibition on beta-cell survival in vitro and in vivo. The mechanisms by which NOX4 inhibition protects insulin producing cells are, however, not known. The aim of the present study was to investigate the effects of a pharmacological NOX4 inhibitor (GLX7013114) on human islet and EndoC-βH1 cell mitochondrial function, and to correlate such effects with survival in islets of different size, activity, and glucose-stimulated insulin release responsiveness. We found that maximal oxygen consumption rates, but not the rates of acidification and proton leak, were increased in islets after acute NOX4 inhibition. In EndoC-βH1 cells, NOX4 inhibition increased the mitochondrial membrane potential, as estimated by JC-1 fluorescence; mitochondrial reactive oxygen species (ROS) production, as estimated by MitoSOX fluorescence; and the ATP/ADP ratio, as assessed by a bioluminescent assay. Moreover, the insulin release from EndoC-βH1 cells at a high glucose concentration increased with NOX4 inhibition. These findings were paralleled by NOX4 inhibition-induced protection against human islet cell death when challenged with high glucose and sodium palmitate. The NOX4 inhibitor protected equally well islets of different size, activity, and glucose responsiveness. We conclude that pharmacological alleviation of NOX4-induced inhibition of beta-cell mitochondria leads to increased, and not decreased, mitochondrial ROS, and this was associated with protection against cell death occurring in different types of heterogeneous islets. Thus, NOX4 inhibition or modulation may be a therapeutic strategy in type 2 diabetes that targets all types of islets." @default.
• W4200260818 created "2021-12-31" @default.
• W4200260818 creator A5033081214 @default.
• W4200260818 creator A5039853407 @default.
• W4200260818 creator A5044460343 @default.
• W4200260818 creator A5052659905 @default.
• W4200260818 creator A5075361231 @default.
• W4200260818 date "2021-12-08" @default.
• W4200260818 modified "2023-10-14" @default.
• W4200260818 title "Pharmacological Inhibition of NOX4 Improves Mitochondrial Function and Survival in Human Beta-Cells" @default.
• W4200260818 cites W1945308826 @default.
• W4200260818 cites W1966672647 @default.
• W4200260818 cites W1985413317 @default.
• W4200260818 cites W1986241637 @default.
• W4200260818 cites W2001105216 @default.
• W4200260818 cites W2035153027 @default.
• W4200260818 cites W2036341824 @default.
• W4200260818 cites W2046616002 @default.
• W4200260818 cites W2055492712 @default.
• W4200260818 cites W2061234580 @default.
• W4200260818 cites W2083454642 @default.
• W4200260818 cites W2116837665 @default.
• W4200260818 cites W2118193478 @default.
• W4200260818 cites W2152414362 @default.
• W4200260818 cites W2185389647 @default.
• W4200260818 cites W2465180814 @default.
• W4200260818 cites W2563598355 @default.
• W4200260818 cites W2603933061 @default.
• W4200260818 cites W2744679708 @default.
• W4200260818 cites W2762275934 @default.
• W4200260818 cites W2794411467 @default.
• W4200260818 cites W2893942679 @default.
• W4200260818 cites W2916124726 @default.
• W4200260818 cites W2973229973 @default.
• W4200260818 cites W2977696708 @default.
• W4200260818 cites W3048177327 @default.
• W4200260818 cites W3087447230 @default.
• W4200260818 cites W3183745159 @default.
• W4200260818 doi "https://doi.org/10.3390/biomedicines9121865" @default.
• W4200260818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34944680" @default.
• W4200260818 hasPublicationYear "2021" @default.
• W4200260818 type Work @default.
• W4200260818 citedByCount "6" @default.
• W4200260818 countsByYear W42002608182022 @default.
• W4200260818 countsByYear W42002608182023 @default.
• W4200260818 crossrefType "journal-article" @default.
• W4200260818 hasAuthorship W4200260818A5033081214 @default.
• W4200260818 hasAuthorship W4200260818A5039853407 @default.
• W4200260818 hasAuthorship W4200260818A5044460343 @default.
• W4200260818 hasAuthorship W4200260818A5052659905 @default.
• W4200260818 hasAuthorship W4200260818A5075361231 @default.
• W4200260818 hasBestOaLocation W42002608181 @default.
• W4200260818 hasConcept C126322002 @default.
• W4200260818 hasConcept C134018914 @default.
• W4200260818 hasConcept C165220095 @default.
• W4200260818 hasConcept C185592680 @default.
• W4200260818 hasConcept C190283241 @default.
• W4200260818 hasConcept C2776828364 @default.
• W4200260818 hasConcept C2779306644 @default.
• W4200260818 hasConcept C2779719074 @default.
• W4200260818 hasConcept C2779765511 @default.
• W4200260818 hasConcept C28859421 @default.
• W4200260818 hasConcept C31573885 @default.
• W4200260818 hasConcept C48349386 @default.
• W4200260818 hasConcept C55493867 @default.
• W4200260818 hasConcept C71924100 @default.
• W4200260818 hasConcept C86803240 @default.
• W4200260818 hasConcept C95444343 @default.
• W4200260818 hasConceptScore W4200260818C126322002 @default.
• W4200260818 hasConceptScore W4200260818C134018914 @default.
• W4200260818 hasConceptScore W4200260818C165220095 @default.
• W4200260818 hasConceptScore W4200260818C185592680 @default.
• W4200260818 hasConceptScore W4200260818C190283241 @default.
• W4200260818 hasConceptScore W4200260818C2776828364 @default.
• W4200260818 hasConceptScore W4200260818C2779306644 @default.
• W4200260818 hasConceptScore W4200260818C2779719074 @default.
• W4200260818 hasConceptScore W4200260818C2779765511 @default.
• W4200260818 hasConceptScore W4200260818C28859421 @default.
• W4200260818 hasConceptScore W4200260818C31573885 @default.
• W4200260818 hasConceptScore W4200260818C48349386 @default.
• W4200260818 hasConceptScore W4200260818C55493867 @default.
• W4200260818 hasConceptScore W4200260818C71924100 @default.
• W4200260818 hasConceptScore W4200260818C86803240 @default.
• W4200260818 hasConceptScore W4200260818C95444343 @default.
• W4200260818 hasIssue "12" @default.
• W4200260818 hasLocation W42002608181 @default.
• W4200260818 hasLocation W42002608182 @default.
• W4200260818 hasLocation W42002608183 @default.
• W4200260818 hasLocation W42002608184 @default.
• W4200260818 hasLocation W42002608185 @default.
• W4200260818 hasOpenAccess W4200260818 @default.
• W4200260818 hasPrimaryLocation W42002608181 @default.
• W4200260818 hasRelatedWork W1583213500 @default.
• W4200260818 hasRelatedWork W1973049774 @default.
• W4200260818 hasRelatedWork W2003485540 @default.
• W4200260818 hasRelatedWork W2028699422 @default.
• W4200260818 hasRelatedWork W2064538767 @default.
• W4200260818 hasRelatedWork W2068108356 @default.

• next