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- W4200262317 endingPage "6136" @default.
- W4200262317 startingPage "6136" @default.
- W4200262317 abstract "The incorporation of novel agents in recent treatments in multiple myeloma (MM) has improved the clinical outcome of patients. Specifically, the approval of monoclonal antibody (MoAb) against CD38 (daratumumab) and SLAMF7 (elotuzumab) in relapsed and refractory MM (RRMM) represents an important milestone in the development of targeted immunotherapy in MM. These MoAb-based agents significantly induce cytotoxicity of MM cells via multiple effector-dependent mechanisms and can further induce immunomodulation to repair a dysfunctional tumor immune microenvironment. Recently, targeting B cell maturation antigen (BCMA), an even MM-specific antigen, has shown high therapeutic activities by chimeric antigen receptor T cells (CAR T), antibody-drug conjugate (ADC), bispecific T-cell engager (BiTE), as well as bispecific antibody (BiAb), with some already approved for heavily pretreated RRMM patients. New antigens, such as orphan G protein-coupled receptor class C group 5 member D (GPRC5D) and FcRH5, were identified and rapidly moved to ongoing clinical studies. We here summarized the pathobiological function of key MM antigens and the status of the corresponding immunotherapies. The potential challenges and emerging treatment strategies are also discussed." @default.
- W4200262317 created "2021-12-31" @default.
- W4200262317 creator A5008057837 @default.
- W4200262317 creator A5019802024 @default.
- W4200262317 creator A5031772152 @default.
- W4200262317 creator A5032464400 @default.
- W4200262317 date "2021-12-06" @default.
- W4200262317 modified "2023-10-17" @default.
- W4200262317 title "Promising Antigens for the New Frontier of Targeted Immunotherapy in Multiple Myeloma" @default.
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