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• W4200264797 endingPage "101332" @default.
• W4200264797 startingPage "101332" @default.
• W4200264797 abstract "Polo-like kinase I (PLK1), a cell cycle regulating kinase, has been shown to have oncogenic function in several cancers. Although PLK1 inhibitors, such as BI2536, BI6727 (volasertib) and NMS-1286937 (onvansertib) are generally well-tolerated with a favorable pharmacokinetic profile, clinical successes are limited due to partial responses in cancer patients, especially those in advanced stages. Recently, combination therapies targeting multiple pathways are being tested for cancer management. In this review, we first discuss structure and function of PLK1, role of PLK1 in cancers, PLK1 specific inhibitors, and advantages of using combination therapy versus monotherapy followed by a critical account on PLK1-based combination therapies in cancer treatments, especially highlighting recent advancements and challenges. PLK1 inhibitors in combination with chemotherapy drugs and targeted small molecules have shown superior effects against cancer both in vitro and in vivo. PLK1-based combination therapies have shown increased apoptosis, disrupted cell cycle, and potential to overcome resistance in cancer cells/tissues over monotherapies. Further, with successes in preclinical experiments, researchers are validating such approaches in clinical trials. Although PLK1-based combination therapies have achieved initial success in clinical studies, there are examples where they have failed to improve patient survival. Therefore, further research is needed to identify and validate novel biologically informed co-targets for PLK1-based combinatorial therapies. Employing a network-based analysis, we identified potential PLK1 co-targets that could be examined further. In addition, understanding the mechanisms of synergism between PLK1 inhibitors and other agents may lead to a better approach on which agents to pair with PLK1 inhibition for optimum cancer treatment." @default.
• W4200264797 created "2021-12-31" @default.
• W4200264797 creator A5025592530 @default.
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• W4200264797 creator A5042168434 @default.
• W4200264797 creator A5044445781 @default.
• W4200264797 creator A5045348217 @default.
• W4200264797 date "2022-02-01" @default.
• W4200264797 modified "2023-10-14" @default.
• W4200264797 title "PLK1 inhibition-based combination therapies for cancer management" @default.
• W4200264797 cites W1427460457 @default.
• W4200264797 cites W1483871710 @default.
• W4200264797 cites W1486461179 @default.
• W4200264797 cites W1535930164 @default.
• W4200264797 cites W1555084674 @default.
• W4200264797 cites W1581731557 @default.
• W4200264797 cites W1767510440 @default.
• W4200264797 cites W1858923536 @default.
• W4200264797 cites W1971954823 @default.
• W4200264797 cites W2028306553 @default.
• W4200264797 cites W2035853571 @default.
• W4200264797 cites W2037552673 @default.
• W4200264797 cites W2082793779 @default.
• W4200264797 cites W2084478721 @default.
• W4200264797 cites W2087387230 @default.
• W4200264797 cites W2094965521 @default.
• W4200264797 cites W2101440707 @default.
• W4200264797 cites W2101725260 @default.
• W4200264797 cites W2105502495 @default.
• W4200264797 cites W2116068077 @default.
• W4200264797 cites W2140364596 @default.
• W4200264797 cites W2149205972 @default.
• W4200264797 cites W2159013299 @default.
• W4200264797 cites W2176851610 @default.
• W4200264797 cites W2223451583 @default.
• W4200264797 cites W2254524854 @default.
• W4200264797 cites W2261194342 @default.
• W4200264797 cites W2279636548 @default.
• W4200264797 cites W2286516112 @default.
• W4200264797 cites W2294442692 @default.
• W4200264797 cites W2333406468 @default.
• W4200264797 cites W2396833496 @default.
• W4200264797 cites W2464405525 @default.
• W4200264797 cites W2467902526 @default.
• W4200264797 cites W2537189148 @default.
• W4200264797 cites W2549761003 @default.
• W4200264797 cites W2562390400 @default.
• W4200264797 cites W2570116345 @default.
• W4200264797 cites W2585444321 @default.
• W4200264797 cites W2591459241 @default.
• W4200264797 cites W2600452401 @default.
• W4200264797 cites W2603411876 @default.
• W4200264797 cites W2606188292 @default.
• W4200264797 cites W2607555575 @default.
• W4200264797 cites W2690406299 @default.
• W4200264797 cites W2725970815 @default.
• W4200264797 cites W2739928434 @default.
• W4200264797 cites W2743762084 @default.
• W4200264797 cites W2744629370 @default.
• W4200264797 cites W2774112395 @default.
• W4200264797 cites W2785713138 @default.
• W4200264797 cites W2791397677 @default.
• W4200264797 cites W2791412889 @default.
• W4200264797 cites W2799449035 @default.
• W4200264797 cites W2804204032 @default.
• W4200264797 cites W2808875729 @default.
• W4200264797 cites W2809923614 @default.
• W4200264797 cites W2883461704 @default.
• W4200264797 cites W2889687851 @default.
• W4200264797 cites W2890093371 @default.
• W4200264797 cites W2894397394 @default.
• W4200264797 cites W2902609075 @default.
• W4200264797 cites W2906852527 @default.
• W4200264797 cites W2919506079 @default.
• W4200264797 cites W2920950068 @default.
• W4200264797 cites W2922122232 @default.
• W4200264797 cites W2944696317 @default.
• W4200264797 cites W2950706836 @default.
• W4200264797 cites W2951071083 @default.
• W4200264797 cites W2953191511 @default.
• W4200264797 cites W2990982401 @default.
• W4200264797 cites W2999040249 @default.
• W4200264797 cites W2999746123 @default.
• W4200264797 cites W3011759723 @default.
• W4200264797 cites W3015646919 @default.
• W4200264797 cites W3036531306 @default.
• W4200264797 cites W3037072276 @default.
• W4200264797 cites W3044350430 @default.
• W4200264797 cites W3081835990 @default.
• W4200264797 cites W3083419928 @default.
• W4200264797 cites W3083479876 @default.
• W4200264797 cites W3087376704 @default.
• W4200264797 cites W3087629880 @default.
• W4200264797 cites W3089243232 @default.
• W4200264797 cites W3090522151 @default.
• W4200264797 cites W3097399419 @default.
• W4200264797 cites W3101782087 @default.
• W4200264797 cites W3103430683 @default.

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