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- W4200268228 abstract "Our research group focus on the development of mono and bis-arylation reactions of pyrimidinones including thiazolo[5,4-f]quinazolin-9-(8H)-ones, mainly conceived as potential kinase inhibitors. During the last decade, diaryliodoniums salts appeared as efficient electrophilic and non-toxic reagents for late-stage arylation. In this context, Cu-catalyzed C-H arylation process using diaryliodonium salts was investigated under microwave irradiation. This sustainable methodology, allowing the introduction of (het)aryl groups on C2 atom of the thiazole moiety, was successfully extended to various fused pyrimidinones. A short library of potential inhibitors of kinases is described." @default.
- W4200268228 created "2021-12-31" @default.
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- W4200268228 date "2021-11-03" @default.
- W4200268228 modified "2023-10-18" @default.
- W4200268228 title "Microwave-assisted copper catalyzed C-H arylation of bioactive pyrimidinones using diaryliodoniums salts" @default.
- W4200268228 doi "https://doi.org/10.3390/ecmc2021-11583" @default.
- W4200268228 hasPublicationYear "2021" @default.
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