Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200275364> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4200275364 endingPage "102024" @default.
- W4200275364 startingPage "102024" @default.
- W4200275364 abstract "Cancer continues to be a prevalent health problem with increasing mortality rates. The interest in complementary medicine for cancer treatment has increased in recent years. In this study, we aimed to investigate whether there are in vitro anticancer effects of a commercially available polyherbal formulation (PHF) against lung cancer.MTS assay, colony formation, wound healing, Annexin-V/PI assays and qRT-PCR were performed to determine the effects of PHF on viability, colony forming ability, migration and apoptosis of non-small cell lung cancer (NSCLC) cells, A549 and human retinal epithelial cells, ARPE-19 as a non-cancerous control.We examined the cytotoxic effect of PHF on cell proliferation in comparison with cisplatin and both showed significant cytotoxic effects on A549 cells. PHF treatment resulted in a relatively mild cytotoxic effect against ARPE-19 cells compared to cisplatin treatment. The inhibition of growth in more than 50% of A549 cells was noted with either 1:25 dilution of PHF or 24 µM of cisplatin treatments. PHF caused a more effective suppression of cell migration compared to cisplatin (P<0.001). Both PHF and cisplatin at IC50 doses effectively inhibited colony formation and induced apoptosis. Bax/Bcl-2 ratio was elevated in A549 cells after both PHF and cisplatin treatments.Our data indicate that PHF might have potent migration inhibitory and apoptosis-inducing activities. More importantly, PHF showed a less cytotoxic effect on normal cells than cisplatin. The mechanisms underlying the anticancer activity of PHF need to be elucidated more comprehensively to confirm its potential as a promising therapeutic candidate." @default.
- W4200275364 created "2021-12-31" @default.
- W4200275364 creator A5016180861 @default.
- W4200275364 creator A5029579355 @default.
- W4200275364 creator A5047492247 @default.
- W4200275364 date "2021-12-01" @default.
- W4200275364 modified "2023-09-25" @default.
- W4200275364 title "Profiling mistletoe therapy research: a systematic review of conditions treated, mode of application" @default.
- W4200275364 doi "https://doi.org/10.1016/j.eujim.2021.102024" @default.
- W4200275364 hasPublicationYear "2021" @default.
- W4200275364 type Work @default.
- W4200275364 citedByCount "0" @default.
- W4200275364 crossrefType "journal-article" @default.
- W4200275364 hasAuthorship W4200275364A5016180861 @default.
- W4200275364 hasAuthorship W4200275364A5029579355 @default.
- W4200275364 hasAuthorship W4200275364A5047492247 @default.
- W4200275364 hasConcept C121608353 @default.
- W4200275364 hasConcept C126322002 @default.
- W4200275364 hasConcept C143998085 @default.
- W4200275364 hasConcept C154317977 @default.
- W4200275364 hasConcept C185592680 @default.
- W4200275364 hasConcept C190283241 @default.
- W4200275364 hasConcept C202751555 @default.
- W4200275364 hasConcept C2776256026 @default.
- W4200275364 hasConcept C2776694085 @default.
- W4200275364 hasConcept C2778239845 @default.
- W4200275364 hasConcept C502942594 @default.
- W4200275364 hasConcept C55493867 @default.
- W4200275364 hasConcept C71924100 @default.
- W4200275364 hasConcept C81729549 @default.
- W4200275364 hasConcept C88634738 @default.
- W4200275364 hasConcept C96232424 @default.
- W4200275364 hasConcept C98274493 @default.
- W4200275364 hasConceptScore W4200275364C121608353 @default.
- W4200275364 hasConceptScore W4200275364C126322002 @default.
- W4200275364 hasConceptScore W4200275364C143998085 @default.
- W4200275364 hasConceptScore W4200275364C154317977 @default.
- W4200275364 hasConceptScore W4200275364C185592680 @default.
- W4200275364 hasConceptScore W4200275364C190283241 @default.
- W4200275364 hasConceptScore W4200275364C202751555 @default.
- W4200275364 hasConceptScore W4200275364C2776256026 @default.
- W4200275364 hasConceptScore W4200275364C2776694085 @default.
- W4200275364 hasConceptScore W4200275364C2778239845 @default.
- W4200275364 hasConceptScore W4200275364C502942594 @default.
- W4200275364 hasConceptScore W4200275364C55493867 @default.
- W4200275364 hasConceptScore W4200275364C71924100 @default.
- W4200275364 hasConceptScore W4200275364C81729549 @default.
- W4200275364 hasConceptScore W4200275364C88634738 @default.
- W4200275364 hasConceptScore W4200275364C96232424 @default.
- W4200275364 hasConceptScore W4200275364C98274493 @default.
- W4200275364 hasLocation W42002753641 @default.
- W4200275364 hasOpenAccess W4200275364 @default.
- W4200275364 hasPrimaryLocation W42002753641 @default.
- W4200275364 hasRelatedWork W2000605857 @default.
- W4200275364 hasRelatedWork W2056951071 @default.
- W4200275364 hasRelatedWork W2348668550 @default.
- W4200275364 hasRelatedWork W2377894959 @default.
- W4200275364 hasRelatedWork W2385438628 @default.
- W4200275364 hasRelatedWork W2388037360 @default.
- W4200275364 hasRelatedWork W2390985545 @default.
- W4200275364 hasRelatedWork W2773240317 @default.
- W4200275364 hasRelatedWork W2789717442 @default.
- W4200275364 hasRelatedWork W1765925496 @default.
- W4200275364 hasVolume "48" @default.
- W4200275364 isParatext "false" @default.
- W4200275364 isRetracted "false" @default.
- W4200275364 workType "article" @default.