Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200276048> ?p ?o ?g. }
- W4200276048 endingPage "1263" @default.
- W4200276048 startingPage "1263" @default.
- W4200276048 abstract "There is a need for better strategies to promote burn wound healing and prevent infection. The aim of our study was to develop an easy-to-use placental multipotent mesenchymal stromal cell (MMSC) secretome-based chitosan hydrogel (MSC-Ch-gel) and estimate its antimicrobial and regenerative activity in Staphylococcus aureus-infected burn wounds in rats.Proteomic studies of the MMSC secretome revealed proteins involved in regeneration, angiogenesis, and defence responses. The MMSC secretome was collected from cultured cells and mixed with water-soluble chitosan to prepare the placental MSC-Ch-gel, which was stored in liquid phase at 4 °C. The wounds of rats with established II-IIIa-degree burns were then infected with S. aureus and externally covered with the MSC-Ch-gel. Three additional rat groups were treated with medical Vaseline oil, the antiseptic drug Miramistin®, or the drug Bepanthen® Plus. Skin wound samples were collected 4 and 8 days after burning for further microbiological and histological analysis. Blood samples were also collected for biochemical analysis.Application of the MSC-Ch-gel cleared the wound of microorganisms (S. aureus wasn't detected in the washings from the burned areas), decreased inflammation, enhanced re-epithelialisation, and promoted the formation of well-vascularised granulation tissue.MSC-Ch-gel effectively promotes infected wound healing in rats with third-degree burns. Gel preparation can be easily implemented into clinical practice." @default.
- W4200276048 created "2021-12-31" @default.
- W4200276048 creator A5013554035 @default.
- W4200276048 creator A5016540931 @default.
- W4200276048 creator A5063885808 @default.
- W4200276048 creator A5069321024 @default.
- W4200276048 creator A5081896743 @default.
- W4200276048 creator A5084862569 @default.
- W4200276048 creator A5084931025 @default.
- W4200276048 creator A5090560163 @default.
- W4200276048 date "2021-12-04" @default.
- W4200276048 modified "2023-09-27" @default.
- W4200276048 title "Antimicrobial and Regenerative Effects of Placental Multipotent Mesenchymal Stromal Cell Secretome-Based Chitosan Gel on Infected Burns in Rats" @default.
- W4200276048 cites W2014250987 @default.
- W4200276048 cites W2025371271 @default.
- W4200276048 cites W2045649797 @default.
- W4200276048 cites W2058979147 @default.
- W4200276048 cites W2070334783 @default.
- W4200276048 cites W2081285252 @default.
- W4200276048 cites W2119189593 @default.
- W4200276048 cites W2138704758 @default.
- W4200276048 cites W2141686927 @default.
- W4200276048 cites W2157599860 @default.
- W4200276048 cites W2170589477 @default.
- W4200276048 cites W2330090019 @default.
- W4200276048 cites W2334773909 @default.
- W4200276048 cites W2341518345 @default.
- W4200276048 cites W2546088870 @default.
- W4200276048 cites W2603755876 @default.
- W4200276048 cites W2603921207 @default.
- W4200276048 cites W2732839963 @default.
- W4200276048 cites W2736653213 @default.
- W4200276048 cites W2747982145 @default.
- W4200276048 cites W2756799582 @default.
- W4200276048 cites W2795369145 @default.
- W4200276048 cites W2884249527 @default.
- W4200276048 cites W2898135257 @default.
- W4200276048 cites W2900226360 @default.
- W4200276048 cites W2917826173 @default.
- W4200276048 cites W2942998834 @default.
- W4200276048 cites W2943521602 @default.
- W4200276048 cites W2962555196 @default.
- W4200276048 cites W2963289631 @default.
- W4200276048 cites W2982871573 @default.
- W4200276048 cites W2985019389 @default.
- W4200276048 cites W2985061269 @default.
- W4200276048 cites W2989805968 @default.
- W4200276048 cites W3006340673 @default.
- W4200276048 cites W3023928131 @default.
- W4200276048 cites W3023994700 @default.
- W4200276048 cites W3025944562 @default.
- W4200276048 cites W3048347821 @default.
- W4200276048 cites W3093245192 @default.
- W4200276048 cites W3093276591 @default.
- W4200276048 cites W3097819935 @default.
- W4200276048 cites W3111626759 @default.
- W4200276048 cites W3118454190 @default.
- W4200276048 cites W3118496755 @default.
- W4200276048 cites W3119483687 @default.
- W4200276048 cites W3121950719 @default.
- W4200276048 cites W3136858840 @default.
- W4200276048 cites W3142544648 @default.
- W4200276048 cites W3158832078 @default.
- W4200276048 cites W3178018615 @default.
- W4200276048 cites W3178210753 @default.
- W4200276048 cites W3183801869 @default.
- W4200276048 cites W3201601156 @default.
- W4200276048 cites W3205278338 @default.
- W4200276048 cites W4239894970 @default.
- W4200276048 doi "https://doi.org/10.3390/ph14121263" @default.
- W4200276048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34959663" @default.
- W4200276048 hasPublicationYear "2021" @default.
- W4200276048 type Work @default.
- W4200276048 citedByCount "9" @default.
- W4200276048 countsByYear W42002760482022 @default.
- W4200276048 countsByYear W42002760482023 @default.
- W4200276048 crossrefType "journal-article" @default.
- W4200276048 hasAuthorship W4200276048A5013554035 @default.
- W4200276048 hasAuthorship W4200276048A5016540931 @default.
- W4200276048 hasAuthorship W4200276048A5063885808 @default.
- W4200276048 hasAuthorship W4200276048A5069321024 @default.
- W4200276048 hasAuthorship W4200276048A5081896743 @default.
- W4200276048 hasAuthorship W4200276048A5084862569 @default.
- W4200276048 hasAuthorship W4200276048A5084931025 @default.
- W4200276048 hasAuthorship W4200276048A5090560163 @default.
- W4200276048 hasBestOaLocation W42002760481 @default.
- W4200276048 hasConcept C126322002 @default.
- W4200276048 hasConcept C142724271 @default.
- W4200276048 hasConcept C16930146 @default.
- W4200276048 hasConcept C178790620 @default.
- W4200276048 hasConcept C185592680 @default.
- W4200276048 hasConcept C198826908 @default.
- W4200276048 hasConcept C203014093 @default.
- W4200276048 hasConcept C2776055305 @default.
- W4200276048 hasConcept C2779489039 @default.
- W4200276048 hasConcept C2779732960 @default.
- W4200276048 hasConcept C2779820397 @default.
- W4200276048 hasConcept C2780269544 @default.