FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200280623> ?p ?o ?g. }

• W4200280623 abstract "Abstract Assessment of everyday activities are central to the diagnosis of pre-dementia and dementia. Yet, little is known about the brain substrates and processes that contribute to everyday functional impairment, particularly during early stages of cognitive decline. We investigated everyday function using a complex gait task in normal older adults stratified by risk of cognitive impairment. We applied a novel EEG approach, which combines electroencephalographic with 3D-body tracking technology to measure brain-gait dynamics with millisecond precision while participants are in motion. Twenty-six participants (mean age = 74.9 years) with cognitive and everyday functional profiles within the normal range for their age and sex were ranked for risk of cognitive impairment. We used the Montreal Cognitive Assessment battery, a global index of cognition with a range from 0 to 30, to classify individuals as being at higher (22-26) and lower risk (27+). Individuals walking on a treadmill were exposed to visual perturbation designed to destabilize gait. Assuming that brain changes precede behavioral decline, we predicted that older adults increase step width to gain stability, yet the underlying neural signatures would be different for lower versus higher risk individuals. When pooling across risk groups, we found that step width increased and fronto-parietal activation shifted from transient, during swing phases, to sustained across the gait cycle during visually perturbed input. As predicted, step width increased in both groups but underlying neural signatures were different. Fronto-medial theta (3-7Hz) power of gait-related brain oscillations were increased in higher risk individuals during both perturbed and unperturbed inputs. On the other hand, left central gyri beta (13-28Hz) power was decreased in lower risk individuals, specifically during visually perturbed input. Finally, relating MoCA scores to spectral power pooled across fronto-parietal regions, we found associations between increased theta power and worse MoCA scores and between decreased beta power and better MoCA scores.Able-bodied older adults at-risk of cognitive impairment are characterized by unique neural signatures of mobility. Stronger reliance on frontomedial theta activation in at-risk individuals may reflect higher-order compensatory responses for deterioration of basic sensorimotor processes. Region and spectral-specific signatures of mobility may provide brain targets for early intervention against everyday functional decline." @default.
• W4200280623 created "2021-12-31" @default.
• W4200280623 creator A5000176766 @default.
• W4200280623 creator A5014531929 @default.
• W4200280623 creator A5054713527 @default.
• W4200280623 creator A5069449714 @default.
• W4200280623 creator A5074195828 @default.
• W4200280623 creator A5090021205 @default.
• W4200280623 date "2021-12-17" @default.
• W4200280623 modified "2023-10-11" @default.
• W4200280623 title "Neural signature of everyday function in older adults at-risk of cognitive impairment" @default.
• W4200280623 cites W1504557066 @default.
• W4200280623 cites W1518874996 @default.
• W4200280623 cites W1596040508 @default.
• W4200280623 cites W1964656041 @default.
• W4200280623 cites W1968294806 @default.
• W4200280623 cites W1973798645 @default.
• W4200280623 cites W1974704788 @default.
• W4200280623 cites W1979776982 @default.
• W4200280623 cites W1981937980 @default.
• W4200280623 cites W1989212226 @default.
• W4200280623 cites W1991291458 @default.
• W4200280623 cites W2000261287 @default.
• W4200280623 cites W2002260612 @default.
• W4200280623 cites W2003877340 @default.
• W4200280623 cites W2005489177 @default.
• W4200280623 cites W2006082701 @default.
• W4200280623 cites W2006243850 @default.
• W4200280623 cites W2010118932 @default.
• W4200280623 cites W2013468866 @default.
• W4200280623 cites W2017982422 @default.
• W4200280623 cites W2021964708 @default.
• W4200280623 cites W2024321742 @default.
• W4200280623 cites W2027875873 @default.
• W4200280623 cites W2028436804 @default.
• W4200280623 cites W2029733815 @default.
• W4200280623 cites W2032146992 @default.
• W4200280623 cites W2033427845 @default.
• W4200280623 cites W2044806915 @default.
• W4200280623 cites W2052684349 @default.
• W4200280623 cites W2060523616 @default.
• W4200280623 cites W2065338300 @default.
• W4200280623 cites W2075976889 @default.
• W4200280623 cites W2078756260 @default.
• W4200280623 cites W2081614980 @default.
• W4200280623 cites W2081842413 @default.
• W4200280623 cites W2089361244 @default.
• W4200280623 cites W2100741386 @default.
• W4200280623 cites W2102103192 @default.
• W4200280623 cites W2104085366 @default.
• W4200280623 cites W2112573938 @default.
• W4200280623 cites W2114479482 @default.
• W4200280623 cites W2116308679 @default.
• W4200280623 cites W2118957880 @default.
• W4200280623 cites W2121528650 @default.
• W4200280623 cites W2128495200 @default.
• W4200280623 cites W2128529067 @default.
• W4200280623 cites W2132677633 @default.
• W4200280623 cites W2139462172 @default.
• W4200280623 cites W2145025818 @default.
• W4200280623 cites W2145775250 @default.
• W4200280623 cites W2148230634 @default.
• W4200280623 cites W2156430527 @default.
• W4200280623 cites W2159239844 @default.
• W4200280623 cites W2165022761 @default.
• W4200280623 cites W2165758561 @default.
• W4200280623 cites W2168183088 @default.
• W4200280623 cites W2169661995 @default.
• W4200280623 cites W2171746332 @default.
• W4200280623 cites W2181719885 @default.
• W4200280623 cites W2203290533 @default.
• W4200280623 cites W2256375944 @default.
• W4200280623 cites W2260435978 @default.
• W4200280623 cites W2277715507 @default.
• W4200280623 cites W2281036808 @default.
• W4200280623 cites W235918678 @default.
• W4200280623 cites W2385081178 @default.
• W4200280623 cites W2404982666 @default.
• W4200280623 cites W2551806420 @default.
• W4200280623 cites W2604355556 @default.
• W4200280623 cites W2615773686 @default.
• W4200280623 cites W2743373469 @default.
• W4200280623 cites W2766265615 @default.
• W4200280623 cites W2780732598 @default.
• W4200280623 cites W2797495168 @default.
• W4200280623 cites W2798054687 @default.
• W4200280623 cites W2885971283 @default.
• W4200280623 cites W2886271036 @default.
• W4200280623 cites W2896204498 @default.
• W4200280623 cites W2906352773 @default.
• W4200280623 cites W2911595089 @default.
• W4200280623 cites W2922239801 @default.
• W4200280623 cites W2950079406 @default.
• W4200280623 cites W2954859553 @default.
• W4200280623 cites W3008965122 @default.
• W4200280623 cites W3036764405 @default.
• W4200280623 cites W3087234141 @default.
• W4200280623 cites W3092320418 @default.
• W4200280623 cites W3157744910 @default.
• W4200280623 cites W4205104973 @default.

• next