FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4200280626> ?p ?o ?g. }

• W4200280626 abstract "Abstract Background Particulate matter (PM) containing environmentally persistent free radicals (EPFRs) are formed during various combustion processes, including the thermal remediation of hazardous wastes. Exposure to PM adversely affects respiratory health in infants and is associated with increased morbidity and mortality due to acute lower respiratory tract infections. We previously reported that early-life exposure to PM damages the lung epithelium and suppresses immune responses to influenza virus (Flu) infection, thereby enhancing Flu severity. Interleukin 22 (IL22) is important in resolving lung injury following Flu infection. In the current study, we determined the effects of PM exposure on pulmonary IL22 responses using our neonatal mouse model of Flu infection. Results Exposure to PM resulted in an immediate (0.5–1-day post-exposure; dpe) increase in IL22 expression in the lungs of C57BL/6 neonatal mice; however, this IL22 expression was not maintained and failed to increase with either continued exposure to PM or subsequent Flu infection of PM-exposed mice. This contrasts with increased IL22 expression in age-matched mice exposed to vehicle and Flu infected. Activation of the aryl hydrocarbon receptor (AhR), which mediates the induction and release of IL22 from immune cells, was also transiently increased with PM exposure. The microbiome plays a major role in maintaining epithelial integrity and immune responses by producing various metabolites that act as ligands for AhR. Exposure to PM induced lung microbiota dysbiosis and altered the levels of indole, a microbial metabolite. Treatment with recombinant IL22 or indole-3-carboxaldehyde (I3A) prevented PM associated lung injury. In addition, I3A treatment also protected against increased mortality in Flu-infected mice exposed to PMs. Conclusions Together, these data suggest that exposure to PMs results in failure to sustain IL22 levels and an inability to induce IL22 upon Flu infection. Insufficient levels of IL22 may be responsible for aberrant epithelial repair and immune responses, leading to increased Flu severity in areas of high PM." @default.
• W4200280626 created "2021-12-31" @default.
• W4200280626 creator A5009566662 @default.
• W4200280626 creator A5024368973 @default.
• W4200280626 creator A5033187365 @default.
• W4200280626 creator A5038669110 @default.
• W4200280626 creator A5052876785 @default.
• W4200280626 date "2021-12-14" @default.
• W4200280626 modified "2023-10-17" @default.
• W4200280626 title "Exposure to combustion derived particulate matter exacerbates influenza infection in neonatal mice by inhibiting IL22 production" @default.
• W4200280626 cites W1420654867 @default.
• W4200280626 cites W1536821636 @default.
• W4200280626 cites W1755020903 @default.
• W4200280626 cites W1964052073 @default.
• W4200280626 cites W1976609469 @default.
• W4200280626 cites W1978912403 @default.
• W4200280626 cites W1979718675 @default.
• W4200280626 cites W1981177186 @default.
• W4200280626 cites W1991346214 @default.
• W4200280626 cites W2012352591 @default.
• W4200280626 cites W2024355140 @default.
• W4200280626 cites W2044216294 @default.
• W4200280626 cites W2048604446 @default.
• W4200280626 cites W2052554412 @default.
• W4200280626 cites W2063164636 @default.
• W4200280626 cites W2064992443 @default.
• W4200280626 cites W2065118613 @default.
• W4200280626 cites W2082583591 @default.
• W4200280626 cites W2087010189 @default.
• W4200280626 cites W2097990779 @default.
• W4200280626 cites W2102366014 @default.
• W4200280626 cites W2106464597 @default.
• W4200280626 cites W2117613919 @default.
• W4200280626 cites W2120348031 @default.
• W4200280626 cites W2120718999 @default.
• W4200280626 cites W2127272185 @default.
• W4200280626 cites W2130082585 @default.
• W4200280626 cites W2133011946 @default.
• W4200280626 cites W2134717682 @default.
• W4200280626 cites W2136047624 @default.
• W4200280626 cites W2140234457 @default.
• W4200280626 cites W2140866982 @default.
• W4200280626 cites W2141970008 @default.
• W4200280626 cites W2145818079 @default.
• W4200280626 cites W2155997615 @default.
• W4200280626 cites W2159498276 @default.
• W4200280626 cites W2163381313 @default.
• W4200280626 cites W2171540770 @default.
• W4200280626 cites W2187800750 @default.
• W4200280626 cites W2344772925 @default.
• W4200280626 cites W2398399679 @default.
• W4200280626 cites W2413745624 @default.
• W4200280626 cites W2437101608 @default.
• W4200280626 cites W2509651511 @default.
• W4200280626 cites W2523426713 @default.
• W4200280626 cites W2544747409 @default.
• W4200280626 cites W2572120777 @default.
• W4200280626 cites W2581115074 @default.
• W4200280626 cites W2586587123 @default.
• W4200280626 cites W2607350314 @default.
• W4200280626 cites W2616454395 @default.
• W4200280626 cites W2781043268 @default.
• W4200280626 cites W2797772478 @default.
• W4200280626 cites W2807027297 @default.
• W4200280626 cites W2889077654 @default.
• W4200280626 cites W2900552520 @default.
• W4200280626 cites W2934244022 @default.
• W4200280626 cites W2936758667 @default.
• W4200280626 cites W2938341288 @default.
• W4200280626 cites W2995023574 @default.
• W4200280626 cites W2997594170 @default.
• W4200280626 cites W3009666649 @default.
• W4200280626 cites W3027658010 @default.
• W4200280626 cites W3083959127 @default.
• W4200280626 cites W4232030241 @default.
• W4200280626 cites W4319308391 @default.
• W4200280626 doi "https://doi.org/10.1186/s12989-021-00438-7" @default.
• W4200280626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34906172" @default.
• W4200280626 hasPublicationYear "2021" @default.
• W4200280626 type Work @default.
• W4200280626 citedByCount "5" @default.
• W4200280626 countsByYear W42002806262022 @default.
• W4200280626 countsByYear W42002806262023 @default.
• W4200280626 crossrefType "journal-article" @default.
• W4200280626 hasAuthorship W4200280626A5009566662 @default.
• W4200280626 hasAuthorship W4200280626A5024368973 @default.
• W4200280626 hasAuthorship W4200280626A5033187365 @default.
• W4200280626 hasAuthorship W4200280626A5038669110 @default.
• W4200280626 hasAuthorship W4200280626A5052876785 @default.
• W4200280626 hasBestOaLocation W42002806261 @default.
• W4200280626 hasConcept C104317684 @default.
• W4200280626 hasConcept C126322002 @default.
• W4200280626 hasConcept C143121216 @default.
• W4200280626 hasConcept C203014093 @default.
• W4200280626 hasConcept C2522874641 @default.
• W4200280626 hasConcept C2776914184 @default.
• W4200280626 hasConcept C2777165150 @default.
• W4200280626 hasConcept C2777546802 @default.
• W4200280626 hasConcept C2777714996 @default.
• W4200280626 hasConcept C2778690821 @default.

• next